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METHYLDIPHENYLPHOSPHINE

Product Name
METHYLDIPHENYLPHOSPHINE
CAS No.
1486-28-8
Chemical Name
METHYLDIPHENYLPHOSPHINE
Synonyms
98% (C6H5)2(CH3)P;Methyldiphenylphsphine;DIPHENYLMETHYLPHOSPHINE;METHYLDIPHENYLPHOSPHINE;Diphenylphosphinomethane;Methyldiphenylphosphine>Phosphine, methyldiphenyl-;Methyldiphenylphosphine 99%;Methyldiphenylphosphine,99%;Methyldiphenylphosphine, 99% 5GR
CBNumber
CB4239518
Molecular Formula
C13H13P
Formula Weight
200.22
MOL File
1486-28-8.mol
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METHYLDIPHENYLPHOSPHINE Property

Melting point:
117-118 °C
Boiling point:
120-122 °C1.5 mm Hg(lit.)
Density 
1.076 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.625(lit.)
Flash point:
>230 °F
storage temp. 
Inert atmosphere,Room Temperature
form 
Liquid
color 
Clear colorless to slightly yellow
Specific Gravity
1.076
Water Solubility 
Insoluble in water.
Sensitive 
Air Sensitive
BRN 
743075
InChI
InChI=1S/C13H13P/c1-14(12-8-4-2-5-9-12)13-10-6-3-7-11-13/h2-11H,1H3
InChIKey
UJNZOIKQAUQOCN-UHFFFAOYSA-N
SMILES
P(C)(C1=CC=CC=C1)C1=CC=CC=C1
CAS DataBase Reference
1486-28-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
17-23-24/25-36/37/39-26
WGK Germany 
3
F 
1-10
TSCA 
No
HS Code 
29420000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
244902
Product name
Methyldiphenylphosphine
Purity
99%
Packaging
1g
Price
$43.76
Updated
2025/07/31
Sigma-Aldrich
Product number
244902
Product name
Methyldiphenylphosphine
Purity
99%
Packaging
10g
Price
$128.7
Updated
2025/07/31
TCI Chemical
Product number
M1318
Product name
Methyldiphenylphosphine
Purity
>97.0%(GC)
Packaging
1g
Price
$63
Updated
2025/07/31
TCI Chemical
Product number
M1318
Product name
Methyldiphenylphosphine
Purity
>97.0%(GC)
Packaging
5g
Price
$146
Updated
2025/07/31
Strem Chemicals
Product number
15-3250
Product name
Methyldiphenylphosphine, 99%
Packaging
5g
Price
$60
Updated
2024/03/01
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METHYLDIPHENYLPHOSPHINE Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liqui

Uses

Methyldiphenylphosphine, is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Application

Methyldiphenylphosphine is an important organophosphorus ligand widely used in catalytic chemistry and materials science. It often forms complexes with transition metals such as palladium, rhodium, and nickel as a monodentate ligand, catalyzing a variety of organic synthesis reactions, such as carbon-carbon coupling reactions (e.g., the Heck and Suzuki reactions), hydroformylation, and asymmetric hydrogenation, effectively enhancing the activity and selectivity of these reactions. Furthermore, due to its unique electronic and steric properties, it is also used in the synthesis of functional materials such as luminescent materials and liquid crystals, and as a protective agent for stabilizing nanoparticles, demonstrating its significant value in organic electronics and nanotechnology.

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: ligand

Synthesis

The mainstream preparation method for methyldiphenylphosphine typically involves a nucleophilic substitution reaction between a Grignard reagent or an organolithium reagent and chlorodiphenylphosphine. The most common approach involves first preparing methylmagnesium bromide (CH₃MgBr) via a Grignard reaction, which is then added dropwise to a solution of chlorodiphenylphosphine in an inert solvent such as diethyl ether or tetrahydrofuran. After the reaction is complete, post-processing steps such as hydrolysis and extraction are performed to remove the byproduct magnesium chloride and unreacted starting materials. Finally, purification is performed by vacuum distillation or recrystallization to obtain the target product, methyldiphenylphosphine.

METHYLDIPHENYLPHOSPHINE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYLDIPHENYLPHOSPHINE Suppliers

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View Lastest Price from METHYLDIPHENYLPHOSPHINE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
METHYLDIPHENYLPHOSPHINE 1486-28-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-06
Shaanxi Dideu Medichem Co. Ltd
Product
Methyldiphenylphosphine 1486-28-8
Price
US $1.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2020-01-16
Henan Bao Enluo International TradeCo.，LTD
Product
METHYLDIPHENYLPHOSPHINE 1486-28-8
Price
US $50.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10000MT
Release date
2023-08-08

1486-28-8, METHYLDIPHENYLPHOSPHINERelated Search:

1,6-Bis(diphenylphosphino)hexane 1,1'-Bis(diphenylphosphino)ferrocene Bis(diphenylphosphino)methane 1,4-Bis(diphenylphosphino)butane TETRAPHENYLPHOSPHINE IMIDE DIPHENYL(PENTAFLUOROPHENYL)PHOSPHINE METHYLDIPHENYLPHOSPHINE OXIDE BIS(2-DIPHENYLPHOSPHINOETHYL)PHENYLPHOSPHINE TRIPHENYLPHOSPHINE DIBROMIDE BIS(PENTAFLUOROPHENYL)PHENYLPHOSPHINE (FORMYLMETHYLENE)TRIPHENYLPHOSPHORANE 1,5-Bis(diphenylphosphino)pentane 1,2-Bis(diphenylphosphino)ethane Triphenylphosphine oxide 1,3-Bis(diphenylphosphino)propane CIS-1,2-BIS(DIPHENYLPHOSPHINO)ETHYLENE TETRAKIS(METHYLDIPHENYLPHOSPHINE)PALLADIUM(0) (1,5-CYCLOOCTADIENE)BIS(METHYLDIPHENYLPHOSPHINE)IRIDIUM(I) HEXAFLUOROPHOSPHATE

  • METHYLDIPHENYLPHOSPHINE
  • DIPHENYLMETHYLPHOSPHINE
  • Methyldiphenylphsphine
  • Methyldiphenylphosphine,99%
  • Diphenylphosphinomethane
  • Methyldiphenylphosphine, 99% 25GR
  • Methyldiphenylphosphine, 99% 5GR
  • 98% (C6H5)2(CH3)P
  • Methyldiphenylphosphine 99%
  • Methyldiphenylphosphine,98% (C6H5)2(CH3)P
  • Methyldiphenylphosphine&gt
  • Phosphine, methyldiphenyl-
  • 1486-28-8
  • C6H52PCH3
  • C13H13P
  • CH3C6H52P
  • Phosphine Ligands
  • Catalysis and Inorganic Chemistry
  • Phosphorus Compounds
  • Achiral Phosphine
  • Aryl Phosphine
  • organophosphorus ligand
  • Ligand
  • Phosphine Ligands
  • Synthetic Organic Chemistry