2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER

Product Name: 2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER
CAS No.: 944401-58-5
Chemical Name: 2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER
Synonyms: EOS-60712;-4-(trifluoromethyl);2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER;2-Amino-4-trifluoromethylpyrimidine-5-boronic acid pinacol ester;2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER ISO 9001：2015 REACH;5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)-2-pyrimidinamine;2-Pyrimidinamine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)-;5-(4,4,5,5-tetramethyl(1,3,2-dioxaborolan-2-yl))-4-(trifluoromethyl)pyrimidine-2-ylamine;[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyrimidin-2-yl]amine
CBNumber: CB42453060
Molecular Formula: C11H15BF3N3O2
Formula Weight: 289.06
MOL File: 944401-58-5.mol

More

Less

2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER Property

Boiling point:: 403.8±55.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 1.80±0.10(Predicted)
Appearance: White to off-white Solid

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

TRC

Product number: A631360
Product name: 2-Amino-4-trifluoropyrimidine-5-boronicAcidPinacolEster
Packaging: 100mg
Price: $335
Updated: 2021/12/16

TRC

Product number: A631360
Product name: 2-Amino-4-trifluoropyrimidine-5-boronicAcidPinacolEster
Packaging: 500mg
Price: $1060
Updated: 2021/12/16

Usbiological

Product number: 259855
Product name: 2-Amino-4-trifluoromethylpyrimidine-5-boronic acid pinacol ester
Packaging: 2g
Price: $1070
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA29199
Product name: 2-Amino-4-trifluoromethylpyrimidine-5-boronic acid pinacol ester
Packaging: 10g
Price: $1140
Updated: 2021/12/16

AK Scientific

Product number: W9682
Product name: 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyrimidin-2-amine
Packaging: 250mg
Price: $227
Updated: 2021/12/16

More

Less

2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER Chemical Properties,Usage,Production

Synthesis

935534-47-7

73183-34-3

944401-58-5

4-Trifluoromethyl-5-bromo-2-pyrimidinamine (16.2 g, 66.3 mmol), pinacol ester of bisboronic acid (18.5 g, 72.9 mmol), and potassium acetate (19.5 g, 199 mmol) were suspended in dioxane (300 mL) under argon protection. To this suspension was added PdCl2(dppf)CH2Cl2 adduct (2.4 g, 2.98 mmol) and the mixture was stirred at 115 °C for 4 hours. After completion of the reaction, the mixture was cooled to 50 °C and treated with ethyl acetate. The resulting suspension was filtered through Hyflo and washed with ethyl acetate. The combined filtrates were concentrated and the residue was suspended in 2N NaOH solution and stirred at room temperature for 5 minutes. Subsequently, ether and water were added and the two-phase mixture formed was filtered through Hyflo. The two phases of the filtrate were separated and the pH of the aqueous phase was adjusted to 5-6 with 4N HCl and then extracted with ethyl acetate. The organic layer was washed sequentially with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was ground in ether and hexane and filtered to give pinacol ester of 2-amino-4-trifluoromethylpyrimidine-5-boronic acid (8.33 g, 42% yield). Retention time (tR): 1.00 min (LC-MS 1); ESI-MS: 290.3 [M + H]+ (LC-MS 1).

References

[1] Patent: US2013/225574, 2013, A1. Location in patent: Paragraph 0504; 0505
[2] Patent: US2014/135330, 2014, A1. Location in patent: Paragraph 0218

2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER Suppliers

China 54 India 1 United Kingdom 1 United States 6 Global 62

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 52923
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

SynInnova Laboratories Inc.

Tel: --
Fax: --
Email: sales@syninnova.com
Country: United States
ProdList: 491
Advantage: 50

More

Less

View Lastest Price from 2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER 944401-58-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Career Henan Chemical Co

Product: 2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER 944401-58-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg; 10kg; 100kg
Release date: 2019-08-30

944401-58-5, 2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTERRelated Search:

2-Amino-3-bromo-6-chloropyrazine 2-AMino-6-broMo-5,6-dihydro-7(4H)-benzothiazolone L-Alanyl-L-Glutamine impurity 25 2-AMino-4-chloro-6-MethylpyriMidine-5-carbonitrile OSU-03012 1H-Imidazole-4-carboxylicacid,2-amino-,ethylester(9CI) 2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridin-2-amine 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)aniline 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethoxy)aniline 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethoxy)aniline 2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER 2-Aminopyrimidine-5-boronic Acid Pinacol Ester

2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER

2-Amino-4-trifluoromethylpyrimidine-5-boronic acid pinacol ester

[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyrimidin-2-yl]amine

EOS-60712

5-(4,4,5,5-tetramethyl(1,3,2-dioxaborolan-2-yl))-4-(trifluoromethyl)pyrimidine-2-ylamine

2-Pyrimidinamine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)-

2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER ISO 9001：2015 REACH

-4-(trifluoromethyl)

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)-2-pyrimidinamine

944401-58-5

C11H15BF3N3O2

C10H16BF3N3O3