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Mitoxantrone hydrochloride

Product Name
Mitoxantrone hydrochloride
CAS No.
70476-82-3
Chemical Name
Mitoxantrone hydrochloride
Synonyms
MITOXANTRONE HCL;novantrone;DHAQ;DHAD;Mitozantrone;IMMunex;cl232315;Novantron;Novatrone;Bisantrone
CBNumber
CB4246424
Molecular Formula
C22H30Cl2N4O6
Formula Weight
517.4028
MOL File
70476-82-3.mol
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Mitoxantrone hydrochloride Property

Melting point:
203-205 C
storage temp. 
2-8°C
solubility 
Sparingly soluble in water, slightly soluble in methanol, practically insoluble in acetone.
form 
Solid
color 
Dark Blue to Black
Water Solubility 
Soluble to 5 mM in water and to 75 mM in DMSO
InChI
InChI=1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H
InChIKey
ZAHQPTJLOCWVPG-UHFFFAOYSA-N
SMILES
C1(O)=C2C(C(=O)C3=C(C2=O)C(NCCNCCO)=CC=C3NCCNCCO)=C(O)C=C1.[H]Cl.[H]Cl
CAS DataBase Reference
70476-82-3(CAS DataBase Reference)
EPA Substance Registry System
Mitoxantrone hydrochloride (70476-82-3)
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Safety

Hazard Codes 
T,T+
Risk Statements 
46-61-26/27/28
Safety Statements 
53-36/37/39-45-22
RIDADR 
3249
WGK Germany 
3
RTECS 
CB5748500
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29146100
Hazardous Substances Data
70476-82-3(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H340May cause genetic defects

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M6545
Product name
Mitoxantrone dihydrochloride
Purity
≥97% (HPLC)
Packaging
10mg
Price
$64.6
Updated
2024/03/01
Sigma-Aldrich
Product number
1445200
Product name
Mitoxantrone hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
400mg
Price
$1210
Updated
2024/03/01
TCI Chemical
Product number
M3110
Product name
Mitoxantrone Dihydrochloride
Packaging
25MG
Price
$38
Updated
2024/03/01
TCI Chemical
Product number
M3110
Product name
Mitoxantrone Dihydrochloride
Packaging
100MG
Price
$101
Updated
2024/03/01
Alfa Aesar
Product number
J66341
Product name
Mitoxantrone dihydrochloride
Packaging
50mg
Price
$152
Updated
2023/06/20
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Mitoxantrone hydrochloride Chemical Properties,Usage,Production

Description

Mitoxantrone hydrochloride is the first of the synthetic anthracenediones related to doxorubicin to reach the marketplace. Mitoxantrone is useful in the treatment of advanced localized and metastatic mammary carcinomas. It is reported to be less cardiotoxic than doxorubicin.

Description

Mitoxantrone is an anthraquinone that intercalates in DNA and inhibits topoisomerase II (IC50 = 5.3 μM), thus inhibiting cell proliferation. It also inhibits HIV-1 integrase (IC50 = 3.8 μM). Mitoxantrone is exported from cells in an ATP- and glutathione-dependent manner by multidrug resistance protein-1. Formulations containing mitoxantrone have been used in the treatment of cancer and multiple sclerosis.

Chemical Properties

Dark blue, electrostatic, hygroscopic powder.

Originator

Lederle (USA)

Uses

Mitoxanthrone hydrochloride USP (Novantrone) is used to traet acute nonlymphocytic leukemia, including myelogenous promyelocytic, monocytic, and erythroid acute leukemias.

Uses

analgesic, antipyretic

Uses

Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone dihydrochloride has recently been shown to be an inhibitor of DNA methylation.

Definition

ChEBI: Mitoxantrone dihydrochloride is a hydrochloride. It has a role as an antineoplastic agent. It contains a mitoxantrone.

Manufacturing Process

A suspension of 12.5 g of 2-(2-aminoethylamino)ethanol in 40 ml of N,N,N',N'-tetramethylethylenediamine is stirred and de-aerated by bubbling nitrogen in for 15 min. A 10.97 g of leuco-1,4,5,8-tetrahydroxyanthraquinone is gradually added with stirring. The suspension is heated and stirred under nitrogen at 50-52°C for 5 hours. The mixture is allowed to stand and cool under nitrogen for 12 hours. The solid is collected by decantation, macerated in ethanol, collected and washed with ethanol giving 15.06 g of the desired product leuco-1,4-bis[2-(2-hydroxyethylamino)ethylamino]-5,8- dihydroxyanthraquinone as a green-gray solid, melting point 129-131°C.
Chloranil oxidation. To 17.86 g of a suspension of the leuco-1,4-bis[2-(2- hydroxyethylamino)ethylamino]-5,8-dihydroxyanthraquinone (0.03 mole) in 2- methoxyethanol was added gradually with stirring 15 ml of 8 N ethanolic hydrogen chloride. The system was chilled with an ice bath and stirred as 7.50 g (0.0305 mole) of chloranil powder was gradually added. The mixture was stirred overnight at room temperature and diluted with 600 ml of ether. The solid was collected and washed with tetrahydrofuran. Yield of 1,4-bis[2-(2- hydroxyethylamino)ethylamino]-5,8-dihydroxyanthraquinone dihydrochloride 21.34 g, melting point 203-205°C (without recrystallisation).

brand name

Novantrone (Serono).

Therapeutic Function

Antineoplastic

General Description

Mitoxantrone is supplied as a blue aqueous solution in 10-and 20-mg vials for IV administration in the treatment of acute lymphoid leukemia, acute myeloid leukemia, breastcancer, prostate cancer, non-Hodgkin’s lymphoma, andmultiple sclerosis. The mechanisms of resistance are thesame as those seen for the anthracyclines. The distributionhalf-life is 1.1 to 3.1 hours, and the drug has a large volumeof distribution (11 L/kg). The elimination half-life rangedfrom 23 to 215 hours, and elimination was primarily via thebile. Metabolism of the agent involves oxidation of the sidechainalcohols to give the monocarboxylic and dicarboxylicacids.Other toxicities are those seen for the anthracyclinesand include myelosuppression, nausea, vomiting, mucositis,diarrhea, and alopecia. The intense color of the parent drugand metabolites may turn the urine blue.

Biological Activity

Mitoxantrone hydrochloride (Mitoxantrone dihydrochloride) is a type II DNA topoisomerase inhibitor. Disrupts DNA synthesis and repair and induces damage by DNA cross-linking. Also inhibits PIM1 kinase (IC50 = 51 nM). Immunomodulatory, antineoplastic and chemotherapeutic agent. Also USP11 inhibitor (IC50= 3.15 μM). Induces cell death of pancreatic cancer cell lines expressing wild-type BRCA2.

Biochem/physiol Actions

Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells. It used clinically as a chemotherapeutic agent against leukemias and solid tumors and as an immune system modulator in multiple sclerosis.

Clinical Use

Mitoxantrone is used in combination with other agents during the initial treatment of acute nonlymphocytic leukemia and hormone-refractory prostate cancer. Recent studies have shown that mitoxantrone also decreases the rate of relapse and disease progression in patients with multiple sclerosis. Although too toxic for use in patients with primary progressive disease, it is available for the treatment of chronic progressive, progressive relapsing, or deteriorating relapsing-remitting multiple sclerosis.

Side effects

Common side effects of Mitoxantrone hydrochloride include: Swelling of the body; Infection, possibly in the blood, especially when white blood cell count is low; Sores in mouth and throat which may cause difficulty swallowing; Diarrhea, nausea, vomiting; Headache; Pain in belly, back, joints, or muscles; Abnormal or absence of menstrual period; Tiredness, fever; Hair loss; Hives, rash. Less common side effects include: Damage to the heart or heart failure which may cause shortness of breath, tiredness and swelling; Bruising, bleeding; Anemia which may cause tiredness, or may require transfusion; Liver damage which may cause yellowing of eyes and skin, swelling; Internal bleeding which may cause belly pain, black tarry stool, blood in vomit; Constipation, loss of appetite; Abnormal sexual function; Worry, depression; Swelling and redness at the site of the injection; Changes in weight; Swelling and redness of the whites of the eye; Increased sweating; Loss of nails, darkening of the skin and nails; Bluish/greenish discoloration of the urine, skin, eyes and saliva. A rare side effect is bone marrow cancer (leukaemia) caused by chemotherapy.

Metabolism

Mitoxantrone excretion primarily is biliary. Both the unchanged drug and inactive metabolites resulting from N-dealkylation, deamination, and oxidation of the resultant aldehyde to the carboxylic acid are observed. Both arms of the structure can be metabolized, leading to mono- or dicarboxylic acid metabolites, which are excreted as the glucuronide conjugate. The conjugated metabolites are an intense, dark blue in color and will result in blue-green urine.

storage

Desiccate at RT

Mitoxantrone hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Mitoxantrone hydrochloride Suppliers

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View Lastest Price from Mitoxantrone hydrochloride manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Mitoxantrone hydrochloride 70476-82-3
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-10-16
Shanghai Biolang Biotechnology Co., Ltd.
Product
Mitoxantrone hydrochloride 70476-82-3
Price
US $9.90-7.70/g
Min. Order
10g
Purity
99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets，Customiz
Supply Ability
1000kgs
Release date
2022-02-21
Zhuozhou Wenxi import and Export Co., Ltd
Product
Mitoxantrone hydrochloride 70476-82-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

70476-82-3, Mitoxantrone hydrochlorideRelated Search:

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  • 1,4-dihydroxy-5,8-bis(2-(2-hydroxyethylamino)ethylamino)anthracene-9,10-dione dihydrochloride
  • Mitoxantrone hydrochloride 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone dihydrochloride
  • Mitoxantrone dihydrochloride, >=99%
  • novantrone
  • MITOXANTRONE DIHYDROCHLORIDE
  • MITOXANTRONE HCL
  • MITOXANTRONE HYDROCHLORIDE
  • MITOXANTRONE HYDROCHLORIDE SALT
  • MITOXANTHRONE HCL
  • mitozantrone hydrochloride
  • DHAQ
  • DHAQ DIHYDROCHLORIDE
  • 1,4-DIHYDROXY-5,8-BIS[2-[(2-HYDROXYETHYL)AMINO]ETHYL]AMINO]-9,10-ANTHRACENEDIONE DIHYDROCHLORIDE
  • 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone dihydrochloride
  • mitozantrone dihydrochloride
  • Mitoxanthrone hydrochloride
  • 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)aMino]ethyl]aMino]-9,10-anthracenedione Hydrochloride
  • Bisantrone
  • IMMunex
  • NCI 301739
  • Novantron
  • Novatrone
  • Mitoxantrone hydrochloride(Mitozantrone hydrochloride
  • Mitoxantrone hydrochlorid
  • 1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-anthracenedion
  • cl232315
  • 1,4-DIHYDROXY-5,8-BIS-[2-(2-HYDROXYETHYLAMINO)ETHYLAMINO]ANTHRAQUINONE 2HCL
  • 1,4-Dihydroxy-5,8-bis-[2-(2-
  • DHAD
  • Mitozantrone
  • NSC-301739
  • MITOXANTRONE HCL USP
  • Mitoxantrone2Hcl
  • MitoxantroneHclEp5
  • 1,4-Dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthrachinondihydrochlorid
  • Mitoxantron HCl
  • Mitoxantrone dihydrochloride,1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride
  • Mitoxantrone Hydrochloride (400 mg)
  • Mitoxantrone hydroch
  • Mitroxantreone hydrochloride
  • 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)aMino]ethyl}aMino)-9,10-dihydroanthracene-9,10-dione dihydrochloride
  • 9,10-Anthracenedione,1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-, dihydrochloride
  • Mitoxantrone hydrochloride CRS
  • Mitoxantrone hydrochloride USP/EP/BP
  • Mitoxantrone HCl (mitozantrone)
  • Mitoxantrone-D8 hydrochloride
  • Mitoxantrone Hydrochloride (1445200)
  • Mitoxantrone Hydrochloride General Notices
  • Mitoxantrone DiHCl
  • 1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthracene-9,10-dione hydrochloride
  • Mitoxantrone (NSC-301739)2HCl
  • 70476-82-3
  • 704766-82-3
  • C22H28N4O62ClH
  • C22H28N4O62HClC22H30Cl2N4O6
  • C22H30Cl2N4O6
  • C22H28N4O62HCl
  • C22H28N4O6x2HCL