N,N'-[1,2-Ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxymethyl)glycine 1,1'-bis[2-(octyloxy)ethyl] ester

N,N'-[1,2-Ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxymethyl)glycine 1,1'-bis[2-(octyloxy)ethyl] ester Property

Melting point:

121-122 °C

Boiling point:

864.8±65.0 °C(Predicted)

Density 

1.161

form 

Solid

pka

2.00±0.10(Predicted)

color 

White to light yellow

InChIKey

FTGBVHPWUIHWRH-UHFFFAOYSA-N

SMILES

C(OC1=CC=CC=C1N(CC(O)=O)CC(OCCOCCCCCCCC)=O)COC1=CC=CC=C1N(CC(O)=O)CC(OCCOCCCCCCCC)=O

Hazard and Precautionary Statements (GHS)

N,N'-[1,2-Ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxymethyl)glycine 1,1'-bis[2-(octyloxy)ethyl] ester Chemical Properties,Usage,Production

Uses

DP-b99 is a chelator of zinc and calcium ions that acts selectively within cell membranes and has neuroprotective properties in animal models of stroke.

References

[1] Kalendarev T, Zupkovitz G, Ioffe V. The unusual gradient elution for reversed phase HPLC of a strong chelator as an active drug substance. J Pharm Biomed Anal. 2001;24(5-6):967-975. DOI:10.1016/s0731-7085(00)00567-7
[2] Diener HC, Schneider D, Lampl Y, Bornstein NM, Kozak A, Rosenberg G. DP-b99, a membrane-activated metal ion chelator, as neuroprotective therapy in ischemic stroke. Stroke. 2008;39(6):1774-1778. DOI:10.1161/STROKEAHA.107.506378