FMoc-NH-5(ethylene glycol)-acetic acid

Product Name: FMoc-NH-5(ethylene glycol)-acetic acid
CAS No.: 635287-26-2
Chemical Name: FMoc-NH-5(ethylene glycol)-acetic acid
Synonyms: FmocNH-P5-CH2CO2H;FMoc-NH-PEG5-CH2COOH;Fmoc-PEG5-acetic acid;Fmoc-NH-5(ethylene glycol)-actic acid;FMoc-NH-5(ethylene glycol)-acetic acid;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azahenicosan-21-oic acid;17-[(9-Fluorenylmethoxycarbonyl)amino]-3,6,9,12,15-pentaoxaheptadecanoic acid;5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid 1-(9H-fluoren-9-ylmethyl) ester;Fmoc-NH-PEG5-CH2COOH(1-(9H-Fluoren-9-ylmethyl) 5,8,11,14,17-pentaoxa-2-azanonadecanedioate);FmocNH-PEG5-CH2COOH/5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester
CBNumber: CB42546850
Molecular Formula: C27H35NO9
Formula Weight: 517.57
MOL File: 635287-26-2.mol

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FMoc-NH-5(ethylene glycol)-acetic acid Property

Boiling point:: 704.3±60.0 °C(Predicted)
Density: 1.224±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 3.39±0.10(Predicted)
form: Viscous Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 0364AP
Product name: Fmoc-NH-PEG5-CH2COOH
Packaging: 250mg
Price: $303
Updated: 2021/12/16

ChemPep

Product number: 280104
Product name: Fmoc-NH-PEG5-CH2COOH
Packaging: 1g
Price: $306
Updated: 2021/12/16

Activate Scientific

Product number: AS103968
Product name: FmocNH-PEG5-CH2COOH
Purity: 95+%
Packaging: 1g
Price: $413
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1412
Product name: Fmoc-NH-PEG5-CH2COOH
Packaging: 500mg
Price: $607
Updated: 2021/12/16

chempep

Product number: 280104
Product name: Fmoc-NH-PEG5-CH2COOH
Purity: >=95%
Packaging: 5g
Price: $820
Updated: 2021/12/16

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FMoc-NH-5(ethylene glycol)-acetic acid Chemical Properties,Usage,Production

Description

Fmoc-NH-PEG5-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Biological Activity

Fmoc-NH-PEG5-CH2COOH is a degradable ADC linker for antibody drug conjugate (ADC) synthesis. It is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target

Cleavable

Alkyl/ether

PEGs

FMoc-NH-5(ethylene glycol)-acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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FMoc-NH-5(ethylene glycol)-acetic acid Suppliers

China 72 India 1 United Kingdom 1 United States 11 Global 85

ChemPep, Inc.

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Aladdin Scientific

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635287-26-2, FMoc-NH-5(ethylene glycol)-acetic acidRelated Search:

alpha, oMega-Dipropionic acid triethylene glycol O-(2-AMINOETHYL)-O-(2-(BOC-AMINO)ETHYL)OCTAETHYLENE GLYCOL HEXAETHYLENE GLYCOL MONOMETHYL ETHER 2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHANOL 2-(2-Methoxyethoxy)ethanamine 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosane-28-thiol HEPTAETHYLENE GLYCOL MONOMETHYL ETHER FMOC-21-AMINO-4,7,10,13,16,19-HEXAOXAHENEICOSANOIC ACID Fmoc-N-amido-PEG11-acid FMoc-NH-8(ethylene glycol)-acetic acid Fmoc-N-amido-PEG17-acid Fmoc-NH-PEG2-CH2CO2H Fmoc-NH-PEG3-CH2COOH Fmoc-N-amido-PEG15-acid 5,8,11,14,17,20,23,26-Octaoxa-2-azanonacosanedioic acid,1-(9-fluren-9-ylmethyl)ester FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID Fmoc-N-amido-PEG14-acid FMoc-NH-PEG9-CH2CH2COOH

Fmoc-PEG5-acetic acid

1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azahenicosan-21-oic acid

FMoc-NH-5(ethylene glycol)-acetic acid

FMoc-NH-PEG5-CH2COOH

5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid 1-(9H-fluoren-9-ylmethyl) ester

Fmoc-NH-5(ethylene glycol)-actic acid

17-[(9-Fluorenylmethoxycarbonyl)amino]-3,6,9,12,15-pentaoxaheptadecanoic acid

{2-[2-(2-{2-[2-(9H-fluoren-9-yl-methoxycarbonylamino)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}acetic acid

FmocNH-P5-CH2CO2H

FmocNH-PEG5-CH2COOH/5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester

Fmoc-NH-PEG5-CH2COOH(1-(9H-Fluoren-9-ylmethyl) 5,8,11,14,17-pentaoxa-2-azanonadecanedioate)

2-[2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid

635287-26-2

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