3-BroMo-5fluoro-4-Methylpyridine
Uses- Product Name
- 3-BroMo-5fluoro-4-Methylpyridine
- CAS No.
- 1211517-76-8
- Chemical Name
- 3-BroMo-5fluoro-4-Methylpyridine
- Synonyms
- 3-BroMo-5fluoro-4-Methylpyridine;Pyridine, 3-bromo-5-fluoro-4-methyl-;3-BroMo-5fluoro-4-Methylpyridine ISO 9001：2015 REACH
- CBNumber
- CB42549967
- Molecular Formula
- C6H5BrFN
- Formula Weight
- 190.01
- MOL File
- 1211517-76-8.mol
3-BroMo-5fluoro-4-Methylpyridine Property
- Boiling point:
- 183.5±35.0 °C(Predicted)
- Density
- 1.592±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.11±0.28(Predicted)
- form
- liquid
- color
- Clear, colourless
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B692658
- Product name
- 3-Bromo-5-fluoro-4-methylpyridine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B692658
- Product name
- 3-Bromo-5-fluoro-4-methylpyridine
- Packaging
- 1g
- Price
- $260
- Updated
- 2021/12/16
- Product number
- HCH0364552
- Product name
- 3-BROMO-5-FLUORO-4-METHYLPYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.2
- Updated
- 2021/12/16
- Product number
- PC201059
- Product name
- 3-Bromo-5-fluoro-4-methylpyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $73
- Updated
- 2021/12/16
- Product number
- 3H32-B-3S
- Product name
- 3-Bromo-5-fluoro-4-methylpyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $117
- Updated
- 2021/12/16
3-BroMo-5fluoro-4-Methylpyridine Chemical Properties,Usage,Production
Uses
3-Bromo-5-fluoro-4-methylpyridine is a heterocyclic organic compound that can be used as an organic chemical intermediate and can be obtained by methylation of 3-bromo-5-fluoropyridine.
Synthesis
407-20-5
74-88-4
1211517-76-8
Step 1: Dissolve 3-bromo-5-fluoropyridine (5.0 g, 28.4 mmol) in anhydrous THF (23 mL) at -78 °C and slowly dropwise add LDA (2M solution of cyclohexane/ethylphenol THF, 21.3 mL, 42.6 mmol) to the solution of anhydrous THF (23 mL), with the dropwise addition time being controlled to be within 10 minutes. After dropwise addition, stirring was continued at -78 °C for 30 min. Subsequently, a solution of anhydrous THF (23 mL) in iodomethane (2.6 mL, 42.6 mmol) was slowly added dropwise, and after completion of dropwise addition, stirring was continued at -78 °C for 30 min. The reaction mixture was warmed to room temperature and stirred for 2 h. Upon completion of the reaction, the reaction was quenched with saturated NaHCO3 solution. NH4Cl solution was added and after stirring for 30 minutes at room temperature, the reaction mixture was extracted with EtOAc. The organic layers were combined, dried and concentrated under reduced pressure, and the residue was purified by column chromatography (SiO2, EtOAc/cyclohexane) to afford the target product 3-bromo-4-methyl-5-fluoropyridine (3.6 g, 66% yield).
References
[1] Patent: WO2015/22073, 2015, A1. Location in patent: Page/Page column 49
[2] Patent: US2013/109720, 2013, A1. Location in patent: Paragraph 0092; 0093
[3] Patent: WO2012/12478, 2012, A1. Location in patent: Page/Page column 48-49
[4] Patent: WO2012/148808, 2012, A1. Location in patent: Page/Page column 49
[5] Patent: WO2013/43520, 2013, A1. Location in patent: Page/Page column 36
3-BroMo-5fluoro-4-Methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
3-BroMo-5fluoro-4-Methylpyridine Suppliers
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View Lastest Price from 3-BroMo-5fluoro-4-Methylpyridine manufacturers
- Product
- 3-BroMo-5fluoro-4-Methylpyridine 1211517-76-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-23
- Product
- 3-Bromo-5fluoro-4-Methylpyridine 1211517-76-8
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-12
- Product
- 3-BroMo-5fluoro-4-Methylpyridine 1211517-76-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-25