ChemicalBook > CAS DataBase List > 5,6,7,8-Tetrahydro-3-hydroxy-2-isopropyl-8,8-dimethyl-1,4-phenanthrenedione

5,6,7,8-Tetrahydro-3-hydroxy-2-isopropyl-8,8-dimethyl-1,4-phenanthrenedione

Product Name: 5,6,7,8-Tetrahydro-3-hydroxy-2-isopropyl-8,8-dimethyl-1,4-phenanthrenedione
CAS No.: 27468-20-8
Chemical Name: 5,6,7,8-Tetrahydro-3-hydroxy-2-isopropyl-8,8-dimethyl-1,4-phenanthrenedione
Synonyms: Neocryptotanshinone Ⅱ;Deoxyneocryptotanshinone;5,6,7,8-Tetrahydro-3-hydroxy-2-isopropyl-8,8-dimethyl-1,4-phenanthrenedione;1,4-Phenanthrenedione, 5,6,7,8-tetrahydro-3-hydroxy-2-isopropyl-8,8-dimethyl-;1,4-Phenanthrenedione, 5,6,7,8-tetrahydro-3-hydroxy-8,8-dimethyl-2-(1-methylethyl)-
CBNumber: CB42651347
Molecular Formula: C19H22O3
Formula Weight: 298.38
MOL File: 27468-20-8.mol

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5,6,7,8-Tetrahydro-3-hydroxy-2-isopropyl-8,8-dimethyl-1,4-phenanthrenedione Property

Boiling point:: 468.0±45.0 °C(Predicted)
Density: 1.179±0.06 g/cm3(Predicted)
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 4.50±1.00(Predicted)
InChI: InChI=1S/C19H22O3/c1-10(2)14-16(20)12-7-8-13-11(6-5-9-19(13,3)4)15(12)18(22)17(14)21/h7-8,10,21H,5-6,9H2,1-4H3
InChIKey: BIDSIGUBHQOWEC-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C3=C(C=C2)C(C)(C)CCC3)C(=O)C(O)=C1C(C)C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Arctom

Product number: AS296806
Product name: NeocryptotanshinoneII
Purity: ≥98%
Packaging: 5mg
Price: $360
Updated: 2021/12/16

Arctom

Product number: CFN92160
Product name: NeocryptotanshinoneII
Purity: ≥98%
Packaging: 5mg
Price: $536
Updated: 2021/12/16

Crysdot

Product number: CD32001773
Product name: Deoxyneocryptotanshinone
Purity: 95+%
Packaging: 5mg
Price: $930
Updated: 2021/12/16

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5,6,7,8-Tetrahydro-3-hydroxy-2-isopropyl-8,8-dimethyl-1,4-phenanthrenedione Chemical Properties,Usage,Production

Uses

Deoxyneocryptotanshinone, a natural tanshinone, is a high affinity BACE1 (Beta-secretase) inhibitor with an IC50 value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 133.5 μM. Deoxyneocryptotanshinone can be used for Alzheimer's disease research[1][2].

target

NF-kB | NOS

References

[1] Ting Yu, et al. Computational insights into β-site amyloid precursor protein enzyme 1 (BACE1) inhibition by tanshinones and salvianolic acids from Salvia miltiorrhiza via molecular docking simulations. Comput Biol Chem. 2018 Jun;74:273-285. DOI:10.1016/j.compbiolchem.2018.04.008
[2] Da Hye Kim, et al. Characterization of the inhibitory activity of natural tanshinones from Salvia miltiorrhiza roots on protein tyrosine phosphatase 1B. Chem Biol Interact. 2017 Dec 25;278:65-73. DOI:10.1016/j.cbi.2017.10.013

5,6,7,8-Tetrahydro-3-hydroxy-2-isopropyl-8,8-dimethyl-1,4-phenanthrenedione Preparation Products And Raw materials

Raw materials

Preparation Products

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27468-20-8, 5,6,7,8-Tetrahydro-3-hydroxy-2-isopropyl-8,8-dimethyl-1,4-phenanthrenedioneRelated Search:

alpha-Terpineol alpha-Cyperone hydroxygenkwanin (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one MOSLOFLAVONE beta-Sitosterol Artemether beta-Eudesmol Hydroxyecdysone 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one 1,2-Didehydrocryptotanshinone Neocryptotanshinone (8S)-1,2,3,4,8,9-Hexahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione TANSHINONE ⅡA Cryptotanshinone

5,6,7,8-Tetrahydro-3-hydroxy-2-isopropyl-8,8-dimethyl-1,4-phenanthrenedione

Deoxyneocryptotanshinone

Neocryptotanshinone Ⅱ

1,4-Phenanthrenedione, 5,6,7,8-tetrahydro-3-hydroxy-8,8-dimethyl-2-(1-methylethyl)-

1,4-Phenanthrenedione, 5,6,7,8-tetrahydro-3-hydroxy-2-isopropyl-8,8-dimethyl-

27468-20-8