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DANSYLCADAVERINE

Product Name
DANSYLCADAVERINE
CAS No.
10121-91-2
Chemical Name
DANSYLCADAVERINE
Synonyms
5-<WBR;Einecs 233-326-9;DANSYLCADAVERINE;MONODANSYL CADAVERINE;MONODANSYLCADAVERINE CRYSTALLINE;DANSYLCADAVERINE, FOR FLUORESCENCE;DANSYLCADAVERINE MONODANSYLCADAVERINE;N-(DIMETHYL-AMINO-NAPHTHA-LENE-SULFONYL)-1;N-(DIMETHYLAMINONAPHTHALENESULFONYL)-1,5-PENTANEDIAMINE;N-(5-AMINOPENTYL)-5-DIMETHYLAMINONAPHTHALENE-1-SULFONAMIDE
CBNumber
CB4266400
Molecular Formula
C17H25N3O2S
Formula Weight
335.46
MOL File
10121-91-2.mol
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DANSYLCADAVERINE Property

Melting point:
137-140 °C
Boiling point:
505.5±60.0 °C(Predicted)
Density 
1.190±0.06 g/cm3(Predicted)
storage temp. 
−20°C
form 
powder
pka
11.96±0.50(Predicted)
color 
Yellow to yellowish green
λmax
335 nm
BRN 
2951070
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 1 month.
Biological Applications
Measuring cardiac autophagic flux; treating cataract,fibrosis,Parkinson’s disease,peritoneal ovarian tumor dissemination,respiratory diseases,lung diseases,Huntington’s disease,spinobulbar atrophy,spinocerebellar ataxia,denta
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
10-23
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
30432
Product name
Dansylcadaverine
Purity
BioReagent, suitable for fluorescence, ≥99.0% (HPLC)
Packaging
100mg
Price
$50.2
Updated
2024/03/01
Sigma-Aldrich
Product number
30432
Product name
Dansylcadaverine
Purity
BioReagent, suitable for fluorescence, ≥99.0% (HPLC)
Packaging
1g
Price
$252
Updated
2024/03/01
Cayman Chemical
Product number
15571
Product name
Monodansylcadaverine
Purity
≥95%
Packaging
100mg
Price
$29
Updated
2024/03/01
Cayman Chemical
Product number
15571
Product name
Monodansylcadaverine
Purity
≥95%
Packaging
250mg
Price
$58
Updated
2024/03/01
Sigma-Aldrich
Product number
D4008
Product name
Dansylcadaverine
Purity
≥97% (TLC)
Packaging
100mg
Price
$44
Updated
2024/03/01
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DANSYLCADAVERINE Chemical Properties,Usage,Production

Description

Monodansylcadaverine (MDC) is a fluorescent marker for autophagic vacuoles. It is an autofluorescent substance incorporated into multilamellar bodies by both an ion trapping mechanism and interaction with membrane lipids, exhibiting a Stokes shift and increased relative fluorescence in hydrophobic environments. MDC selectively accumulates in PaTu 8902 subcellular fractions containing the lysosomal enzymes acid phosphatase and cathepsin D, but not those containing the rough and smooth endoplasmic reticulum markers TRAM and cytochrome P450, respectively.

Uses

Fluorescent substrate for the assay of transamidating enzymes.

Uses

Lysosomotropic fluorescent Probe

Uses

Dansylcadaverine is a fluorescent amine probe, which is believed to directly inhibit vesicular transport. Studies indicate that Dansylcadaverine can act as a marker used to study autophagy in the cytoplasm and vacuoles of plants and mammalian cells.

Definition

ChEBI: Monodansylcadaverine is a sulfonamide obtained by formal condensation of the sulfo group of 5-(dimethylamino)naphthalene-1-sulfonic acid with one of the amino groups of cadaverine. It has a role as a fluorochrome, a protective agent and an EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor. It is a sulfonamide, an aminonaphthalene, a tertiary amino compound and a primary amino compound. It is functionally related to a cadaverine.

References

1) Munafo and Colombo (2001),?A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation; Int. J. Cell Sci.,?114?3619 2) Jiang?et al. (2012),?Targeting androgen receptor leads to suppression of prostate cancer via induction of autophagy; J. Urol.,?188?1361 3) Haigler?et al.?(1980),?Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells; J. Biol. Chem., 255 1239 4) Murthy?et al. (1994),?Residue Gln-30 of human erythrocyte anion transporter is a prime site for reaction with intrinsic transglutaminase; J. Biol. Chem.,?269?22907

DANSYLCADAVERINE Preparation Products And Raw materials

Raw materials

Preparation Products

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DANSYLCADAVERINE Suppliers

China 76 France 1 Germany 3 India 1 Switzerland 2 United Kingdom 3 United States 21 Global 107
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4552
Advantage
62
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Synchem OHG
Tel
+49 5662 408730
Fax
+49 5662 4087320
Email
info@synchem.de
Country
Germany
ProdList
4705
Advantage
70
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
7295
Advantage
60
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27313
Advantage
60
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
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View Lastest Price from DANSYLCADAVERINE manufacturers

Career Henan Chemical Co
Product
DANSYLCADAVERINE 10121-91-2
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-03

10121-91-2, DANSYLCADAVERINERelated Search:

YM155 MIF Antagonist, ISO-1 Metformin hydrochloride N,N-Dimethylaniline N,N-Dimethylcyclohexylamine N,N-DIMETHYLHYDROXYLAMINE HYDROCHLORIDE N,N'-Dimethyl-1,3-propanediamine N,N-Dimethylbenzylamine N,N-Dimethylbenzamide FMOC-L-LYS(DANSYL)-OH N-EPSILON-DANSYL-L-LYSINE DIDANSYL-L-LYSINE DANSYLCADAVERINE DIDANSYLCADAVERINE DANSYLCADAVERINE DANSYL-PGGQQIV-OH BOC-LYS(DNS)-OH 1,5-DANSYL-GLU-GLY-ARG CHLOROMETHYL KETONE, DIHYDROCHLORIDE

  • 1-Naphthalenesulfonamide, N-(5-aminopentyl)-5-(dimethylamino)-
  • Monodansyl cadaverine, N-(5-Aminopentyl)-5-dimethylaminonaphthalene-1-sulfonamide, N-(Dimethylaminonaphthalenesulfonyl)-1,5-pentanediamine
  • N-(5-Aminopentyl)-5-(dimethylamino)-1-naphthalenesulfonamide
  • Einecs 233-326-9
  • Dansylcadaverine [N-(5-AMinopentyl)-5-diMethylaMinonaphthalen-1-sulfonaMide]
  • <I>N</I>-<WBR>(5-<WBR>Amino-pentyl)<WBR>-<WBR>5-<WBR>di-methyl-amino-naphtha-lene-<WBR>1-<WBR>sulfon-amide
  • <I>N</I>-<WBR>(Dimethyl-amino-naphtha-lene-sulfonyl)<WBR>-<WBR>1
  • 5-<WBR
  • DANSYLCADAVERINE [N-(5-AMINOPENTYL)-5-DIMETHYLAMINONAPHTHALEN-1-SULFONAMIDE];<I>N</I>-<WBR>(5-<WBR>AMINO-PENTYL)<WBR>-<WBR>5-<WBR>DI-METHYL-AMINO-NAPHTHA-LENE-<WBR>1-<WBR>SULFON-AMIDE;<I>N</I>-<WBR>(DIMETHYL-AMINO-NAPHTHA-LENE-SULFONYL)<WBR>-<WBR>1;5-<WBR
  • 5-DIMETHYLAMINONAPHTHALENE-1-(N-(5-AMINOPENTYL))-SULFONAMIDE
  • N-(5-AMINOPENTYL)-5-DIMETHYLAMINONAPHTHALENE-1-SULFONAMIDE
  • MONODANSYL CADAVERINE
  • N-(DIMETHYLAMINONAPHTHALENESULFONYL)-1,5-PENTANEDIAMINE
  • DANSYLCADAVERINE
  • DANSYLCADAVERINE MONODANSYLCADAVERINE
  • N-(5-aminopentyl)-5-(dimethylamino)naphthalene-1-sulphonamide
  • DANSYLCADAVERINE, FOR FLUORESCENCE
  • MONODANSYLCADAVERINE CRYSTALLINE
  • Dansyl cadaverine [5-Dimethylaminonaphthalene-1-(N-(5-aminopentyl))sulfonamide]
  • N-(5-AMINO-PChemicalbookENTYL)-5-DI-METHYL-AMINO-NAPHTHA-LENE-1-SULFON-AMIDE
  • N-(DIMETHYL-AMINO-NAPHTHA-LENE-SULFONYL)-1
  • N-(5-Aminopentyl)-5-(dimethylamino)naphthalene-1-sulfonamide[Dansylcadaverine
  • vacuoles,Inhibitor,probe,Dansylcadaverine,autophagic,Autophagy,autofluorescent,substrate,inhibit
  • 10121-91-2
  • C17H25BN3O2S
  • C17H25N3O2S
  • Biochemicals and Reagents
  • BioChemical
  • Fluorescent Probes, Labels, Particles and Stains
  • Fluorescent Enzyme Substrates
  • Detection
  • Alphabetical
  • Naphthalene