(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE
- Product Name
- (S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE
- CAS No.
- 247580-43-4
- Chemical Name
- (S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE
- Synonyms
- SB 328437;SB 328437 >=98% (HPLC);SB 328437, CCR3 antagonist;SB 328437 - CAS 247580-43-4 - Calbiochem;SB 328437 (DMSO solution), CCR3 antagonist;(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE;Methyl (S)-2-(1-naphthamido)-3-(4-nitrophenyl)propanoate;Methyl (2S)-2-(1-naphthoylaMino)-3-(4-nitrophenyl)propanoate;N-(1-Naphthalenylcarbonyl)-4-nitro-L-phenylalaninemethylester;L-Phenylalanine, N-(1-naphthalenylcarbonyl)-4-nitro-, methyl ester
- CBNumber
- CB4283869
- Molecular Formula
- C21H18N2O5
- Formula Weight
- 378.38
- MOL File
- Mol file
(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Property
- Boiling point:
- 642.9±50.0 °C(Predicted)
- Density
- 1.305±0.06 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- DMSO: ≥10mg/mL
- pka
- 12.51±0.46(Predicted)
- form
- White solid
- color
- white to tan
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H400Very toxic to aquatic life
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 29677
- Product name
- SB 328437
- Packaging
- 1mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- 29677
- Product name
- SB 328437
- Packaging
- 5mg
- Price
- $111
- Updated
- 2024/03/01
- Product number
- SML0207
- Product name
- SB 328437
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $116
- Updated
- 2025/07/31
- Product number
- 29677
- Product name
- SB 328437
- Packaging
- 10mg
- Price
- $202
- Updated
- 2024/03/01
- Product number
- 3650
- Product name
- SB 328437
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $195
- Updated
- 2021/12/16
(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Chemical Properties,Usage,Production
Uses
SB 328437 is a potent and selective CCR3 receptor antagonist.
Biological Activity
SB 328437 inhibits the recruitment and migration of eosinophils in allergen models of models. It suppresses the Th2-mediated eosinophil infiltration in the airways.', 'SB-328437 is a potent, selective CCR-3 antagonist (IC50 = 1.6 nM). The compound blockes CCR3 agonist-induced calcium mobilization in CCR3 expressing cells with the following IC50 values: eotaxin, 38 nM; eotaxin-2, 35 nM and MCP4, 20 nM.
in vivo
SB-328437 (intraperitoneal injection; 5 g/kg; single dose) has a beneficial effect in mouse models of LPS (HY-D1056)-induced lung injury and influenza virus infection[2].
| Animal Model: | Influenza A strain pmd09 treated C57BL/6 female mice aged 8-10 weeks old (18-20 g) [2] |
| Dosage: | 5 g/kg |
| Administration: | Intraperitoneal injection (i.p.); single dose |
| Result: | Reduced neutrophil recruitment to the lung alveolar space. Reduced tissue damage. Reduced lung inflammation and the expression of pro-inflammatory cytokines, Tnfa and Cxcl1. Decreased the activation level of neutrophils. Lowered the viral load in mice. |
IC 50
CCR3: 4.5 nM (IC50)
storage
Store at +4°C
(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Suppliers
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- customerservice@tocris.co.uk
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- solutions@vwr.com
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- United Kingdom
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