ChemicalBook > CAS DataBase List > 5-Chlorothiophene-2-sulfonyl chloride

5-Chlorothiophene-2-sulfonyl chloride

Product Name
5-Chlorothiophene-2-sulfonyl chloride
CAS No.
2766-74-7
Chemical Name
5-Chlorothiophene-2-sulfonyl chloride
Synonyms
AKOS B019398;BUTTPARK 27\04-09;TIMTEC-BB SBB003378;ART-CHEM-BB B019398;5-chlorothiophene-2-sulfonyl;5-CHLOROTHIOPHENESULPHONYL CHLORIDE;5-CHLORO-2-THIENYLSULFONYL CHLORIDE;5-Chlorothiophen-2-sulfonyl chloride;5-CHLOROTHIOPHENE-2-SULFONYL CHLORIDE;5-CHLORO-2-THIOPHENESULFONYL CHLORIDE
CBNumber
CB4283960
Molecular Formula
C4H2Cl2O2S2
Formula Weight
217.09
MOL File
2766-74-7.mol
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5-Chlorothiophene-2-sulfonyl chloride Property

Melting point:
25-28°C
Boiling point:
112-117 °C (lit.)
Density 
1.623 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.586(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
form 
solid
Specific Gravity
1.623
color 
Colorless to Yellow to Orange
Water Solubility 
Not miscible in water.
Sensitive 
Moisture Sensitive
BRN 
130710
InChIKey
SORSTNOXGOXWAO-UHFFFAOYSA-N
CAS DataBase Reference
2766-74-7(CAS DataBase Reference)
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Safety

Hazard Codes 
C
Risk Statements 
34-29-14
Safety Statements 
26-27-36/37/39-45-28A-25
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
Hazard Note 
Corrosive
HazardClass 
8
PackingGroup 
II
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
544272
Product name
5-Chlorothiophene-2-sulfonyl chloride
Purity
96%
Packaging
5g
Price
$17.16
Updated
2024/03/01
Sigma-Aldrich
Product number
544272
Product name
5-Chlorothiophene-2-sulfonyl chloride
Purity
96%
Packaging
1g
Price
$25
Updated
2023/06/20
TCI Chemical
Product number
C2343
Product name
5-Chloro-2-thiophenesulfonyl Chloride
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$59
Updated
2024/03/01
TCI Chemical
Product number
C2343
Product name
5-Chloro-2-thiophenesulfonyl Chloride
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$236
Updated
2024/03/01
Alfa Aesar
Product number
A11348
Product name
5-Chlorothiophene-2-sulfonyl chloride, 97%
Packaging
1g
Price
$39.65
Updated
2024/03/01
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5-Chlorothiophene-2-sulfonyl chloride Chemical Properties,Usage,Production

Chemical Properties

5-Chlorothiophene-2-sulfonyl chloride is white to yellow crystalline low melting solid

Uses

5-Chloro-2-thiophenesulfonyl Chloride is a sulfonylthiophene derivative used in the preparation of Notch-1-sparing γ-secretase inhibitors for the treatment of Alzheimer's disease.

Uses

5-Chlorothiophene-2-sulfonyl chloride is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs. It is used in the preparation of Notch-1-sparing γ-secretase inhibitors for the treatment of Alzheimer's disease.

Synthesis Reference(s)

Tetrahedron, 21, p. 1333, 1965 DOI: 10.1016/S0040-4020(01)98293-6

General Description

5-Chlorothiophene-2-sulfonyl chloride can be prepared from 2-chlorothiophene by reacting with chlorosulfonic acid in the presence of phosphorus pentachloride.

5-Chlorothiophene-2-sulfonyl chloride Preparation Products And Raw materials

Raw materials

2-Chlorothiophene Chlorosulfonic acid Phosphorus pentachloride Diethyl ether

Preparation Products

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5-Chlorothiophene-2-sulfonyl chloride Suppliers

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View Lastest Price from 5-Chlorothiophene-2-sulfonyl chloride manufacturers

Career Henan Chemical Co
Product
5-Chlorothiophene-2-sulfonyl chloride 2766-74-7
Price
US $2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customise
Release date
2018-08-09

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  • TIMTEC-BB SBB003378
  • 5-Chlorothiophene-2-sulfonyl chloride 96%
  • 5-CHLORO-2-THIENYLSULFONYL CHLORIDE
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  • ART-CHEM-BB B019398
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  • 5-Chlloro-2-thiophenesulfonyl Chloride
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  • 2766-74-7
  • 2766-74-4
  • C4H2Cl2O2S2
  • C4H2O2Cl2S2
  • C4H2O2S2Cl2
  • C4H2Cl2S2O2
  • Building Blocks
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Thiophenes
  • Building Blocks
  • C4 to C6
  • Chemical Synthesis
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Heterocycle-oher series
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Thiophenes
  • ThiophenesBuilding Blocks
  • Thiophene&Benzothiophene
  • Thiophene intermediates
  • Heterocycles