ChemicalBook > CAS DataBase List > FILIPIN COMPLEX

FILIPIN COMPLEX

Product Name
FILIPIN COMPLEX
CAS No.
11078-21-0
Chemical Name
FILIPIN COMPLEX
Synonyms
FILIPIN;filmirisin;filimirasin;14-deoxylagosin;FILIPIN COMPLEX;FILIPIN COMPLEX USP/EP/BP;FILIPIN COMPLEX FROM STREPTOMYCES &;filipin complex from streptomyces filipinensis
CBNumber
CB4291136
Molecular Formula
C35H58O11
Formula Weight
654.82842
MOL File
11078-21-0.mol
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FILIPIN COMPLEX Property

Melting point:
195-205°
alpha 
D22 -148.3° (c = 0.89 in methanol)
storage temp. 
−20°C
solubility 
methanol: 10 mg/mL, clear, very dark yellow
form 
powder
color 
yellow
Merck 
13,4111
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
LK4400000
F 
10
HS Code 
2941900000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F9765
Product name
Filipin complex from Streptomyces filipinensis
Purity
≥70% (UV)
Packaging
25mg
Price
$212
Updated
2024/03/01
Sigma-Aldrich
Product number
F9765
Product name
Filipin complex from Streptomyces filipinensis
Purity
≥70% (UV)
Packaging
50mg
Price
$388
Updated
2024/03/01
Cayman Chemical
Product number
25073
Product name
Filipin Complex
Purity
≥95%
Packaging
5mg
Price
$60
Updated
2024/03/01
Cayman Chemical
Product number
25073
Product name
Filipin Complex
Purity
≥95%
Packaging
25mg
Price
$148
Updated
2024/03/01
ChemScene
Product number
CS-0064593
Product name
Filipincomplex
Purity
>97.0%
Packaging
50mg
Price
$280
Updated
2021/12/16
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FILIPIN COMPLEX Chemical Properties,Usage,Production

Uses

Filipin complex comprises a family of pentaene macrocyclic lactones first isolated from Streptomyces filipinensis and reported by researchers at Upjohn in 1955. Filipin complex consists of four analogues, with filipin III comprising the bulk (>70%) of the complex. Filipin complex is a potent broad spectrum antifungal agent that also exhibits antitumor and antiviral activities. Filipin complex acts by binding cell membrane sterols, disrupting membrane integrity.

Uses

Filipin complex from Streptomyces filipinensis has been used as a profluorescence probe to detect the free cholesterol in cell.

Definition

ChEBI: Filipin III is a macrolide that is the major component of a mixture of four isomeric polyene macrolides isolated from Streptomyces filipinensis. It has a role as a bacterial metabolite and a fluorescent probe. It is a macrolide, a polyol and an olefinic compound.

General Description

Chemical structure: macrolide

Biochem/physiol Actions

Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action is unclear but may be due to altering membrane permeability. Filipin binds to model crystalline phase lipid bilayers containing cholesterol, and to liquid phase bilayers with or without cholesterol, in an orientation that forms membrane pores.It both inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.

FILIPIN COMPLEX Preparation Products And Raw materials

Raw materials

Preparation Products

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FILIPIN COMPLEX Suppliers

China 44 Germany 1 India 1 Switzerland 1 United Kingdom 1 United States 7 Global 55
Hunan Hui Bai Shi Biotechnology Co., Ltd.
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View Lastest Price from FILIPIN COMPLEX manufacturers

Career Henan Chemical Co
Product
FILIPINCOMPLEX 11078-21-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
KG/T
Release date
2019-12-17

11078-21-0, FILIPIN COMPLEXRelated Search:

TERT-BUTYL ISOCYANIDE Ethyl isocyanoacetate Tosylmethyl isocyanide Tris(2,4-pentanedionato)chroMiuM(III) PHENYLSELENOL Cupric acetylacetonate Benzyl isocyanide Ferric acetylacetonate COBALT(II) ACETYLACETONATE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) 2,4-PENTANEDIONE, SILVER DERIVATIVE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) N-BUTYLISOCYANIDE Aluminum acetylacetonate METHYL ISOCYANOACETATE 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE SALCOMINE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)

  • 14-deoxylagosin
  • filimirasin
  • filmirisin
  • FILIPIN
  • FILIPIN COMPLEX
  • filipin complex from streptomyces filipinensis
  • FILIPIN COMPLEX FROM STREPTOMYCES &
  • FILIPIN COMPLEX USP/EP/BP
  • 11078-21-0
  • BioChemical
  • Antibiotics
  • Antibiotics A to Z
  • Antibiotics A-F
  • AntifungalPlasma&Blood Proteins
  • Filipin complexAntibiotics
  • MacrolidesApplication Index
  • Serum ProteinsMore...Close...
  • Antibiotics
  • Antibiotics A to
  • Antibiotics A-FAntibiotics
  • Chemical Structure Class
  • Interferes with Cell Membrane Permeability (Ionophores)Antibiotics
  • Mechanism of Action
  • Plasma, Blood, and Related Proteins and Reagents
  • Serum Proteins and Related Enzymes
  • Spectrum of Activity