ChemicalBook > CAS DataBase List > Dihydrokawain

Dihydrokawain

Product Name
Dihydrokawain
CAS No.
587-63-3
Chemical Name
Dihydrokawain
Synonyms
MARINDININ;DIHYDROKAVAIN;DIHYDROKAWAIN;dihydro-kawai;DIHYDROKAWAIN;DIHYDROKAVAIN(P);Dihydrokavain-RM;7,8-Dihydrokavain;7,8-DIHYDROKAWAIN;(S)-(+)-7,8-Dihydrokavain
CBNumber
CB4314738
Molecular Formula
C14H16O3
Formula Weight
232.27
MOL File
587-63-3.mol
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Dihydrokawain Property

Melting point:
58-60°
alpha 
D24 +31° (methanol)
Boiling point:
314.44°C (rough estimate)
Density 
1.1649 (rough estimate)
refractive index 
1.5557 (estimate)
storage temp. 
2-8°C
solubility 
DMF:25.0(Max Conc. mg/mL);107.62(Max Conc. mM)
DMSO:25.0(Max Conc. mg/mL);107.62(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);21.52(Max Conc. mM)
form 
Solid
color 
White to off-white
optical activity
[α]/D 29±2°, c = 0.5 in methanol
BRN 
15362
InChIKey
VOOYTQRREPYRIW-LBPRGKRZSA-N
LogP
1.950 (est)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
41866
Product name
(S)-(+)-7,8-Dihydrokavain
Purity
analytical standard
Packaging
5mg
Price
$539
Updated
2022/05/15
Usbiological
Product number
361778
Product name
Dihydrokawain
Packaging
10mg
Price
$581
Updated
2021/12/16
TRC
Product number
D450620
Product name
(+)-(S)-Dihydrokavain
Packaging
1mg
Price
$185
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD76571
Product name
Dihydrokawain
Packaging
10mg
Price
$250
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PXT0000214
Product name
DIHYDROKAVAIN
Purity
95.00%
Packaging
5MG
Price
$713.26
Updated
2021/12/16
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Dihydrokawain Chemical Properties,Usage,Production

Chemical Properties

White-pale yellow powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the rhizome of kava-kava (Piper methysticum G. Forst).

Uses

(+)-(S)-Dihydrokavain is a kavalactone found in kava beverages consumed by South Pacific islanders. Furthermore, roots and extracts of the kava plant have been used in herbal medicine to treat sleep disturbances, as well as stress and anxiety.

Definition

ChEBI: Dihydrokavain is a member of 2-pyranones and an aromatic ether.

Application

Dihydrokavain is one of the six major kavalactones found in the kava plant; appears to contribute significantly to the anxiolytic effects of kava, based on a study in chicks.Used in herbal medicine to treat sleep disturbances, as well as stress and anxiety.

Preparation

Starting from 2,3-O-isopropylidene-D-glyceraldehyde (2) as chiral material, the naturally occurring (S)-(+)-dihydrokavain (1a) was synthesized by a procedure that involves a sonochemical Blaise reaction as the key step. The absolute configuration of (S)-(+)-dihydrokavain (1a) is demonstrated for the first time by total synthesis from a chiral source. Its opposite enantiomer, (R)-(–)-dihydrokavain (1b), was also synthesized after inversion of the chiral center in a Mitsunobu reaction.
A Total Synthesis of (+)- and (–)-Dihydrokavain with a Sonochemical Blaise Reaction as the Key Step

Dihydrokawain Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Dihydrokawain manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Dihydrokavain 587-63-3
Price
US $0.00/mg
Min. Order
20mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-04-27
Career Henan Chemical Co
Product
DIHYDROKAVAIN 587-63-3
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,50kg
Release date
2020-01-18

587-63-3, DihydrokawainRelated Search:

LICOCHALCONE-A Vincristine Chenodeoxycholic acid Diammonium glycyrrhizinate koumine DihydrocurcuMin Cianidanol 5,6-DIHYDRO-2H-PYRAN-2-ONE 3,4-Dihydro-2H-pyran Kavain DIHYDROKAVAIN DIHYDROMETHYSTICIN Dihydrokawain 5,6-DIHYDRO-4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE 5,6-DIHYDRO-4-METHOXY-2H-PYRAN PARASORBICACID DIHYDROKAVAIN SNAP-N-SHOOT 0.1mg/mL(P) 11,12-DIMETHOXYDIHYDROKAWAIN

  • (R)-5,6-Dihydro-4-methoxy-6-phenethyl-2H-pyran-2-one
  • 4-Methoxy-6-phenethyl-5,6-dihydropyran-2-one
  • 4-methoxy-2-(2-phenylethyl)-2,3-dihydropyran-6-one
  • (6S)-5,6-Dihydro-4-methoxy-6-(2-phenylethyl)-2H-pyran-2-one
  • (S)-(+)-7,8-Dihydrokavain
  • DIHYDROKAWAIN
  • DIHYDROKAVAIN
  • MARINDININ
  • 7,8-DIHYDROKAWAIN
  • 5,6-dihydro-4-methoxy-6-phenethyl-2h-pyran-2-on
  • 7,8-Dihydrokavain
  • Dihydrokavain (7,8-Dihydrokawain
  • DIHYDROKAVAIN(P)
  • 6-dihydro-4-methoxy-6-(2-phenylethyl)-(s)-2h-pyran-2-on
  • dihydro-kawai
  • (6R)-4-Methoxy-6-phenethyl-5,6-dihydro-2H-pyran-2-one
  • Dihydrokavain, 98%, from Piper methysticum Forst
  • 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-(2-phenylethyl)-, (6S)-
  • DIHYDROKAWAIN
  • Dihydrokavain-RM
  • 587-63-3
  • Coumarins