koumine

Product Name: koumine
CAS No.: 1358-76-5
Chemical Name: koumine
Synonyms: koumine;Koumine-RM;Koumine, 10 mM in DMSO;(3R,7alpha,20alpha)-1,2,18,19-Tetradehydro-3,17-epoxy-7,20(2H,19H)cyclovobasan;7,20(2H,19H)-Cyclovobasan, 1,2,18,19-tetradehydro-3,17-epoxy-, (3R,7alpha,20alpha)-;(3S,4S,4aR,6R,11bS,11cS)-2-Methyl-11c-vinyl-1,2,3,4,4a,5,6,11c-octahydro-6,4-(epoxymethano)-3,11b-methanopyrido[4,3-c]carbazole;6,4-(Epoxymethano)-3,11b-methano-11bH-pyrido[4,3-c]carbazole, 11c-ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-, (3S,4S,4aR,6R,11bS,11cS)-
CBNumber: CB31480541
Molecular Formula: C20H22N2O
Formula Weight: 306.4
MOL File: 1358-76-5.mol

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koumine Property

Melting point:: 168℃
Boiling point:: 436.5±45.0 °C(Predicted)
Density: 1.42
storage temp.: 2-8°C
solubility: DMSO : 31.25 mg/mL (101.99 mM; Need ultrasonic)
form: powder
pka: 8.67±0.40(Predicted)
color: Yellow-brown
optical activity: [α]/D 295 to 245°
InChI: InChI=1/C20H22N2O/c1-3-19-11-22(2)16-9-20(19)13-6-4-5-7-15(13)21-18(20)17-8-14(19)12(16)10-23-17/h3-7,12,14,16-17H,1,8-11H2,2H3/t12-,14+,16-,17+,19-,20+/s3
InChIKey: VTLYEMHGPMGUOT-KWZROIJWNA-N
SMILES: C1C=CC2N=C3[C@]4([H])OC[C@@]5([H])[C@]([H])([C@]6(C=C)CN(C)[C@]5(C[C@@]36C=2C=1)[H])C4 |&1:6,10,12,14,20,22,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL84231
Product name: Koumine
Purity: phyproof<SUP>®</SUP> Reference Substance
Packaging: 10 mg
Price: $549
Updated: 2025/07/31

Usbiological

Product number: 300533
Product name: Koumine
Packaging: 10mg
Price: $439
Updated: 2021/12/16

TRC

Product number: K655750
Product name: Koumine
Packaging: 100mg
Price: $2310
Updated: 2021/12/16

ApexBio Technology

Product number: N2312
Product name: Koumine
Packaging: 20mg
Price: $450
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FK73903
Product name: Koumine
Packaging: 100mg
Price: $867
Updated: 2021/12/16

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koumine Chemical Properties,Usage,Production

Description

The Chinese drug 'Kou-wen', said to be derived from Gelsemium elegans Benth., is stated to contain this alkaloid which forms rhombic prisms from Me2 CO. It has [α]²³_D - 265° (EtOH) and forms a crystalline hydrochloride, m.p. 255°C (dec.) and a hydrobromide, m.p. 269°C (dec.).

Chemical Properties

Soluble in acetone, chloroform, ether, benzene and other organic solvents, insoluble in water. Sourced from Gelsemium elegans (Gardn. et Champ.) Benth.

Occurrence

Koumine is an alkaloid isolated from Gelsemium elegans Benth.

Uses

Koumine is known to attenuate the lipopolysaccharide-stimulated inflammation in RAW264.7 macrophages.

in vivo

Koumine is less toxic, with the median lethal dose (LD₅₀) of 300.0 mg/kg on Wistar rats. Koumine (0.6, 3, or 15 mg/kg/per, p.o.) exhibits antirheumatic properties in rats with adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA)^[2].
Koumine inhibits the increase in cytokines in joint tissue and TNF-α level in serum at 15 mg/kg, and suppresses the increase in the serum level of IL-1β at 3 and 15 mg/kg^[2].
Koumine (0.28, 7 mg/kg, s.c.) significantly reduces neuropathic pain after nerve injury. Koumine suppresses the increased Iba-1 protein level^[3].

References

Chou, Pak, Hou., Chin. 1. Physiol., 5, 345 (1931)
Chou, Wang, Chen., ibid, 8,40 (1934)
Chi, Kao, Huang., 1. Amer. Chem. Soc., 60, 1723 (1938)

koumine Preparation Products And Raw materials

Raw materials

Preparation Products

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koumine Suppliers

China 180 India 1 United Kingdom 1 United States 13 Global 195

Huzhou ZhanShu Biotechnology Co.,Ltd

Tel: 0572-8889530 18167260939
Email: zsubio@163.com
Country: China
ProdList: 392
Advantage: 58

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5653
Advantage: 65

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Chengdu Climax Biotech Co., Ltd.

Tel: 028-83311324 1278112614
Fax: 028-83311324
Email: climaxbiotech@gmail.com
Country: China
ProdList: 925
Advantage: 58

Shanghai Ruji Biology Technology Co., Ltd.

Tel: +86-21-65211385-8001 36031160
Fax: +86-21-65211385-8004
Email: sales@shruji.com
Country: China
ProdList: 3224
Advantage: 55

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3988
Advantage: 66

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View Lastest Price from koumine manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Koumine 1358-76-5
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-01-02

Zhuozhou Wenxi import and Export Co., Ltd

Product: koumine 1358-76-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: koumine 1358-76-5
Price: US $1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-24

1358-76-5, koumineRelated Search:

HuMantenidine VERATRIDINE daurisoline humantenine SENNIDINE A dihydrolycorine HISPIDULIN Pachymic acid Catharanthine LICOCHALCONE-A Vincristine Dihydrokawain Chenodeoxycholic acid Diammonium glycyrrhizinate DihydrocurcuMin Cianidanol koumine 3-SPIRAL INDOLE-4-PIPERIDINE

koumine

(3R,7alpha,20alpha)-1,2,18,19-Tetradehydro-3,17-epoxy-7,20(2H,19H)cyclovobasan

7,20(2H,19H)-Cyclovobasan, 1,2,18,19-tetradehydro-3,17-epoxy-, (3R,7alpha,20alpha)-

6,4-(Epoxymethano)-3,11b-methano-11bH-pyrido[4,3-c]carbazole, 11c-ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-, (3S,4S,4aR,6R,11bS,11cS)-

(3S,4S,4aR,6R,11bS,11cS)-2-Methyl-11c-vinyl-1,2,3,4,4a,5,6,11c-octahydro-6,4-(epoxymethano)-3,11b-methanopyrido[4,3-c]carbazole

Koumine-RM

Koumine, 10 mM in DMSO

1358-76-5

58-76-5

Alkaloids

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract