koumine

ChemicalBook > CAS DataBase List > koumine

Product Name: koumine
CAS No.: 1358-76-5
Chemical Name: koumine
Synonyms: koumine;Koumine-RM;(3R,7alpha,20alpha)-1,2,18,19-Tetradehydro-3,17-epoxy-7,20(2H,19H)cyclovobasan;7,20(2H,19H)-Cyclovobasan, 1,2,18,19-tetradehydro-3,17-epoxy-, (3R,7alpha,20alpha)-;(3S,4S,4aR,6R,11bS,11cS)-2-Methyl-11c-vinyl-1,2,3,4,4a,5,6,11c-octahydro-6,4-(epoxymethano)-3,11b-methanopyrido[4,3-c]carbazole;6,4-(Epoxymethano)-3,11b-methano-11bH-pyrido[4,3-c]carbazole, 11c-ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-, (3S,4S,4aR,6R,11bS,11cS)-
CBNumber: CB31480541
Molecular Formula: C20H22N2O
Formula Weight: 306.4
MOL File: 1358-76-5.mol

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koumine Property

Melting point:: 168℃
Boiling point:: 436.5±45.0 °C(Predicted)
Density: 1.42
storage temp.: 2-8°C
solubility: DMSO : 31.25 mg/mL (101.99 mM; Need ultrasonic)
form: powder
pka: 8.67±0.40(Predicted)
color: Yellow-brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 300533
Product name: Koumine
Packaging: 10mg
Price: $439
Updated: 2021/12/16

TRC

Product number: K655750
Product name: Koumine
Packaging: 100mg
Price: $2310
Updated: 2021/12/16

ApexBio Technology

Product number: N2312
Product name: Koumine
Packaging: 20mg
Price: $450
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FK73903
Product name: Koumine
Packaging: 100mg
Price: $867
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb594062
Product name: Koumine
Packaging: 20mg
Price: $550.8
Updated: 2021/12/16

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koumine Chemical Properties,Usage,Production

Description

The Chinese drug 'Kou-wen', said to be derived from Gelsemium elegans Benth., is stated to contain this alkaloid which forms rhombic prisms from Me2 CO. It has [α]²³_D - 265° (EtOH) and forms a crystalline hydrochloride, m.p. 255°C (dec.) and a hydrobromide, m.p. 269°C (dec.).

Occurrence

Koumine is an alkaloid isolated from Gelsemium elegans Benth.

Uses

Koumine is known to attenuate the lipopolysaccharide-stimulated inflammation in RAW264.7 macrophages.

References

Chou, Pak, Hou., Chin. 1. Physiol., 5, 345 (1931)
Chou, Wang, Chen., ibid, 8,40 (1934)
Chi, Kao, Huang., 1. Amer. Chem. Soc., 60, 1723 (1938)

koumine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from koumine manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Koumine 1358-76-5
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-01-02

Zhuozhou Wenxi import and Export Co., Ltd

Product: koumine 1358-76-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: koumine 1358-76-5
Price: US $1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-24

1358-76-5, koumineRelated Search:

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koumine

(3R,7alpha,20alpha)-1,2,18,19-Tetradehydro-3,17-epoxy-7,20(2H,19H)cyclovobasan

7,20(2H,19H)-Cyclovobasan, 1,2,18,19-tetradehydro-3,17-epoxy-, (3R,7alpha,20alpha)-

6,4-(Epoxymethano)-3,11b-methano-11bH-pyrido[4,3-c]carbazole, 11c-ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-, (3S,4S,4aR,6R,11bS,11cS)-

(3S,4S,4aR,6R,11bS,11cS)-2-Methyl-11c-vinyl-1,2,3,4,4a,5,6,11c-octahydro-6,4-(epoxymethano)-3,11b-methanopyrido[4,3-c]carbazole

Koumine-RM

1358-76-5

58-76-5

Alkaloids

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract