dihydrolycorine
Uses- Product Name
- dihydrolycorine
- CAS No.
- 6271-21-2
- Chemical Name
- dihydrolycorine
- Synonyms
- Dihydrolycorine, 10 mM in DMSO;Dihydrolycorine,inhibit,Inhibitor;(1S,2S,3aR,3a1R,12bS)-2,3,3a,3a1,4,5,7,12b-Octahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol;(1S,2S,3aR,12bS,12cR)-2,3,3a,4,5,7,12b,12c-Octahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol;1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,3,3a,4,5,7,12b,12c-octahydro-, (1S,2S,3aR,12bS,12cR)-
- CBNumber
- CB71381082
- Molecular Formula
- C16H19NO4
- Formula Weight
- 289.33
- MOL File
- 6271-21-2.mol
dihydrolycorine Property
- Melting point:
- 247 °C
- Boiling point:
- 460.5±45.0 °C(Predicted)
- Density
- 1.48
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Cryst.
- pka
- 14.13±0.40(Predicted)
- color
- White to off-white
- InChI
- InChI=1S/C16H19NO4/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19/h4-5,8,11,14-16,18-19H,1-3,6-7H2/t8-,11+,14+,15-,16-/m1/s1
- InChIKey
- VJILFEGOWCJNIK-MGRBZGILSA-N
- SMILES
- [C@H]1(O)[C@]2([H])[C@]3([H])N(CC[C@]3([H])C[C@@H]1O)CC1C2=CC2OCOC=2C=1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 27809
- Product name
- Dihydrolycorine
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $39
- Updated
- 2026/04/30
- Product number
- 27809
- Product name
- Dihydrolycorine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $106
- Updated
- 2026/04/30
- Product number
- 27809
- Product name
- Dihydrolycorine
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $175
- Updated
- 2026/04/30
- Product number
- 27809
- Product name
- Dihydrolycorine
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $385
- Updated
- 2026/04/30
- Product number
- 27809
- Product name
- Dihydrolycorine
- Packaging
- 1mg
- Price
- $67
- Updated
- 2024/03/01
dihydrolycorine Chemical Properties,Usage,Production
Uses
Dihydrolycorine is a derivative of Lycorine, the main phenanthridine Amaryllidaceae alkaloid which exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli.
Description
Dihydrolycorine is a derivative of the alkaloid lycorine that has antihypertensive and neuroprotective activities. It inhibits methoxamine-induced contraction of isolated rabbit aortic rings and rat anococcygeus muscle with pA2 values of 5.93 and 6.35, respectively. Dihydrolycorine reduces mean arterial pressure (MAP) in anesthetized and conscious normotensive rats when administered at a dose of 80 mg/kg. It also reduces electrically or phenylephrine-induced hypertension in pithed rats. Dihydrolycorine reduces infarct size, cerebral edema, and myeloperoxidase activity in a rat model of focal cerebral ischemia-reperfusion injury when administered following reperfusion.
Chemical Properties
Colorless columnar crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Lycoris radiata bulbs.
Uses
Dihydrolycorine is a derivative of Lycorine (L487550), the main phenanthridine Amaryllidaceae alkaloid which exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli.
in vivo
Dihydrolycorine inhibits methoxamine-induced contraction of isolated rabbit aortic rings and rat anococcygeus muscle with pA2 values of 5.93 and 6.35, respectively[2].
target
Adrenergic Receptor
References
[1] B Y CHEN. [Hypotensive effect of dihydrolycorine].[J]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1993, 14 1: 45-49.
[2] HONG-YAN CHEN. [Protective effect of hyperin on focal cerebral ischemia reperfusion injury in rats].[J]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine, 2006, 4 5: 526-529. DOI: 10.3736/jcim20060518
dihydrolycorine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from dihydrolycorine manufacturers
- Product
- dihydrolycorine 6271-21-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- dihydrolycorine 6271-21-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- Dihydrolycorine 6271-21-2
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09