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koumine

Product Name
koumine
CAS No.
1358-76-5
Chemical Name
koumine
Synonyms
koumine;Koumine-RM;(3R,7alpha,20alpha)-1,2,18,19-Tetradehydro-3,17-epoxy-7,20(2H,19H)cyclovobasan;7,20(2H,19H)-Cyclovobasan, 1,2,18,19-tetradehydro-3,17-epoxy-, (3R,7alpha,20alpha)-;(3S,4S,4aR,6R,11bS,11cS)-2-Methyl-11c-vinyl-1,2,3,4,4a,5,6,11c-octahydro-6,4-(epoxymethano)-3,11b-methanopyrido[4,3-c]carbazole;6,4-(Epoxymethano)-3,11b-methano-11bH-pyrido[4,3-c]carbazole, 11c-ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-, (3S,4S,4aR,6R,11bS,11cS)-
CBNumber
CB31480541
Molecular Formula
C20H22N2O
Formula Weight
306.4
MOL File
1358-76-5.mol
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koumine Property

Melting point:
168℃
Boiling point:
436.5±45.0 °C(Predicted)
Density 
1.42
storage temp. 
2-8°C
solubility 
DMSO : 31.25 mg/mL (101.99 mM; Need ultrasonic)
form 
powder
pka
8.67±0.40(Predicted)
color 
Yellow-brown
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
300533
Product name
Koumine
Packaging
10mg
Price
$439
Updated
2021/12/16
TRC
Product number
K655750
Product name
Koumine
Packaging
100mg
Price
$2310
Updated
2021/12/16
Biosynth Carbosynth
Product number
FK73903
Product name
Koumine
Packaging
5mg
Price
$86
Updated
2021/12/16
Biosynth Carbosynth
Product number
FK73903
Product name
Koumine
Packaging
10mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0016874
Product name
Koumine
Purity
99.97%
Packaging
5mg
Price
$190
Updated
2021/12/16
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koumine Chemical Properties,Usage,Production

Description

The Chinese drug 'Kou-wen', said to be derived from Gelsemium elegans Benth., is stated to contain this alkaloid which forms rhombic prisms from Me2 CO. It has [α]23D - 265° (EtOH) and forms a crystalline hydrochloride, m.p. 255°C (dec.) and a hydrobromide, m.p. 269°C (dec.).

Occurrence

Koumine is an alkaloid isolated from Gelsemium elegans Benth.

Uses

Koumine is known to attenuate the lipopolysaccharide-stimulated inflammation in RAW264.7 macrophages.

References

Chou, Pak, Hou., Chin. 1. Physiol., 5, 345 (1931)
Chou, Wang, Chen., ibid, 8,40 (1934)
Chi, Kao, Huang., 1. Amer. Chem. Soc., 60, 1723 (1938)

koumine Preparation Products And Raw materials

Raw materials

Preparation Products

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koumine Suppliers

China 152 India 1 United Kingdom 1 United States 13 Global 167
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from koumine manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Koumine 1358-76-5
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-01-02
Zhuozhou Wenxi import and Export Co., Ltd
Product
koumine 1358-76-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
koumine 1358-76-5
Price
US $1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-24

1358-76-5, koumineRelated Search:

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  • koumine
  • (3R,7alpha,20alpha)-1,2,18,19-Tetradehydro-3,17-epoxy-7,20(2H,19H)cyclovobasan
  • 7,20(2H,19H)-Cyclovobasan, 1,2,18,19-tetradehydro-3,17-epoxy-, (3R,7alpha,20alpha)-
  • 6,4-(Epoxymethano)-3,11b-methano-11bH-pyrido[4,3-c]carbazole, 11c-ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-, (3S,4S,4aR,6R,11bS,11cS)-
  • (3S,4S,4aR,6R,11bS,11cS)-2-Methyl-11c-vinyl-1,2,3,4,4a,5,6,11c-octahydro-6,4-(epoxymethano)-3,11b-methanopyrido[4,3-c]carbazole
  • Koumine-RM
  • 1358-76-5
  • 58-76-5
  • Alkaloids
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract