2-Bromo-5-cyanopyridine
- Product Name
- 2-Bromo-5-cyanopyridine
- CAS No.
- 139585-70-9
- Chemical Name
- 2-Bromo-5-cyanopyridine
- Synonyms
- 2-Br-5-CN-pyridine;6-BroMonicotinitrile;6-Bromo-3-cynopyridine;2-BROMO-5-CYNOPYRIDINE;2-BROMO-5-CYANOPYRIDINE;6-BROMO-NICOTINONITRILE;5-Cyano-2-bromopyridine;6-Bromonicotinonitrile 95%;2-Bromo-5-cyanopyridine 97%;2-Bromo-5-cyanopyridine >
- CBNumber
- CB4315452
- Molecular Formula
- C6H3BrN2
- Formula Weight
- 183.01
- MOL File
- 139585-70-9.mol
2-Bromo-5-cyanopyridine Property
- Melting point:
- 136-140
- Boiling point:
- 261.6±20.0 °C(Predicted)
- Density
- 1.72±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Solid
- pka
- -2.66±0.10(Predicted)
- color
- White to Yellow to Orange
- CAS DataBase Reference
- 139585-70-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-41-37/38-22
- Safety Statements
- 26-36/37/39-39-24/25
- RIDADR
- 3439
- WGK Germany
- 3
- Hazard Note
- Irritant/Keep Cold
- HazardClass
- IRRITANT
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CDS003693
- Product name
- 2-bromo-5-cyanopyridine
- Purity
- AldrichCPR
- Packaging
- 250mg
- Price
- $70.9
- Updated
- 2024/03/01
- Product number
- B4039
- Product name
- 2-Bromo-5-cyanopyridine
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $39
- Updated
- 2025/07/31
- Product number
- B4039
- Product name
- 2-Bromo-5-cyanopyridine
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $124
- Updated
- 2025/07/31
- Product number
- B682833
- Product name
- 2-Bromo-5-cyanopyridine
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- B682833
- Product name
- 2-Bromo-5-cyanopyridine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
2-Bromo-5-cyanopyridine Chemical Properties,Usage,Production
Chemical Properties
White to yellow crystalline solid
Uses
6-Bromonicotinonitrile is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Synthesis Reference(s)
The Journal of Organic Chemistry, 66, p. 1500, 2001 DOI: 10.1021/jo005682n
Synthesis
33252-28-7
139585-70-9
The general procedure for the synthesis of 2-bromo-5-cyanopyridine from 2-chloro-5-cyanopyridine is as follows: Example 29 Synthesis of 6-bromonicotinonitrile. 6-Chloronicotinonitrile (13.8 g, 100 mmol) was mixed with phosphorus tribromide (150 mL) and the reaction was heated at 145°C for 32 hours. After completion of the reaction, the mixture was cooled and concentrated in vacuum. To the concentrated residue, phosphorus tribromide (150 mL) was added again and the reaction was heated at 145°C for 32 hours. At the end of the reaction, the mixture was cooled and concentrated under vacuum. The concentrated residue was slowly added to an ice-water mixture (500 mL) and the reaction mixture was neutralized with sodium bicarbonate. Subsequently, the product was extracted with ethyl acetate (3 x 250 mL). The organic phases were combined, washed with saturated brine and dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure and the residue was purified by column chromatography (eluent: hexane-ethyl acetate) to afford 14.9 g (81% yield) of 6-bromonicotinonitrile as a white solid. The product was characterized as follows: 1H NMR (400 MHz, CDCl3) δ 7.66 (d, J = 11.0 Hz, 1H), 7.80 (dd, J = 3.1, 11.0 Hz, 1H), 8.67 (d, J = 3.1 Hz, 1H); mass spectra (M + H)+ m/z = 183.0, 185.0.
References
[1] Patent: US2005/192302, 2005, A1. Location in patent: Page/Page column 30
[2] Patent: WO2012/114223, 2012, A1. Location in patent: Page/Page column 56
[3] Journal of Organic Chemistry, 2001, vol. 66, # 4, p. 1500 - 1502
2-Bromo-5-cyanopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Bromo-5-cyanopyridine Suppliers
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View Lastest Price from 2-Bromo-5-cyanopyridine manufacturers
- Product
- 2-Bromo-5-cyanopyridine 139585-70-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-12
- Product
- 2-Bromo-5-cyanopyridine 139585-70-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-14
- Product
- 2-Bromo-5-cyanopyridine 139585-70-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10