2-Chloro-1-p-tolyl-ethanone

ChemicalBook > CAS DataBase List > 2-Chloro-1-p-tolyl-ethanone

2-Chloro-1-p-tolyl-ethanone

Product Name: 2-Chloro-1-p-tolyl-ethanone
CAS No.: 4209-24-9
Chemical Name: 2-Chloro-1-p-tolyl-ethanone
Synonyms: 4-(2-chloroacetyl)toluene;p-Methylphenacyl chloride;CHLOROMETHYL P-TOLYL KETONE;2-CHLORO-1-P-TOLYL-ETHANONE;p-Methyl-2-chloroacetophenone;4'-Methyl-2-chloroacetophenone;A-CHLORO-4-METHYL ACETOPHENONE;2-CHLORO-4'-METHYLACETOPHENONE;α-Chloro-4'-methylacetophenone;Chloromethyl 4-methylphenyl ketone
CBNumber: CB4322474
Molecular Formula: C9H9ClO
Formula Weight: 168.62
MOL File: 4209-24-9.mol

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2-Chloro-1-p-tolyl-ethanone Property

Melting point:: 57.5°C
Boiling point:: 238.18°C (rough estimate)
Density: 1.1115 (rough estimate)
refractive index: 1.5620 (estimate)
InChI: InChI=1S/C9H9ClO/c1-7-2-4-8(5-3-7)9(11)6-10/h2-5H,6H2,1H3
InChIKey: HGLJRZYKFVJSEE-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=C(C)C=C1)CCl
CAS DataBase Reference: 4209-24-9(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H303May be harmfulif swallowed

H313May be harmful in contact with skin

Precautionary statements

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: C374215
Product name: 2-chloro-1-(4-methylphenyl)ethanone
Packaging: 10mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: P247
Product name: 4-(2-Chloroacetyl)toluene
Packaging: 100mg
Price: $216
Updated: 2021/12/16

AK Scientific

Product number: P247
Product name: 4-(2-Chloroacetyl)toluene
Packaging: 250mg
Price: $253
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0024009
Product name: CHLOROMETHYL P-TOLYL KETONE
Purity: 95.00%
Packaging: 1G
Price: $692.46
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0024009
Product name: CHLOROMETHYL P-TOLYL KETONE
Purity: 95.00%
Packaging: 2.5G
Price: $932.6
Updated: 2021/12/16

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2-Chloro-1-p-tolyl-ethanone Chemical Properties,Usage,Production

Uses

2-chloro-1-(4-methylphenyl)ethanone (cas# 4209-24-9) can be used for preparation of acetophenone derivatives, which are known to be fungicides that control phytopathogenic fungi. In addition, this compound can be used for synthesis of clinafloxacin triazole hybrids, which are also known for the their antifungal and antibacterial activity. Moreover, this compound was found to inhibit (uncompetitively to ATP) pyruvate dehydrogenase (PDH), meaning it inhibits further glucose oxidation. That is why this compound can potentially be used to treat such conditions as diabetes and/or ischemia.

Preparation

To a suspension of anhydrous aluminum chloride (5.60 g, 40 mmol) in anhydrous toluene (40 mL), chloroacetyl chloride (4.52 g, 40 mmol) was slowly added dropwise. After the aluminum chloride had dissolved, the mixture was heated slowly to 80 °C and held at that temperature for 2 h, then cooled and poured into crushed ice (100 g)containing concentrated hydrochloric acid (10 mL). The reaction liquid is extracted by toluene, concentrated, and dried to obtain 2-Chloro-1-p-tolyl-ethanone.

Synthesis Reference(s)

Synthetic Communications, 20, p. 1625, 1990 DOI: 10.1080/00397919008053082

Hazard

Chloromethyl p-tolyl ketone is a danger compound.
H290 (33.33%): May be corrosive to metals [Warning Corrosive to Metals]
H302 (66.67%): Harmful if swallowed [Warning Acute toxicity, oral]
H314 (33.33%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
H315 (66.67%): Causes skin irritation [Warning Skin corrosion/irritation]
H318 (66.67%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
H319 (33.33%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H334 (66.67%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
H335 (66.67%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

2-Chloro-1-p-tolyl-ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Chloro-1-p-tolyl-ethanone manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Chloromethyl p-tolyl ketone 4209-24-9
Price: US $1.00-35.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 15000KG
Release date: 2024-08-08

Shanghai Xinchem Co., Ltd.

Product: Chloromethyl p-tolyl ketone 4209-24-9
Price: US $0.00-0.00/drums
Min. Order: 1drums
Purity: 99%min.
Supply Ability: 10tons
Release date: 2023-10-22

4209-24-9, 2-Chloro-1-p-tolyl-ethanoneRelated Search:

Trichloroacetyl chloride 4'-Hydroxyacetophenone 4-Nitroacetophenone 2-Bromoacetophenone METSULFURON METHYL 4'-Methylacetophenone Acetophenone Methyl acrylate Phenoxyacetyl chloride Vinylbenzyl chloride 4'-(Trifluoromethyl)acetophenone 4-(Chloromethyl)benzoic acid 3-Nitroacetophenone Bensulfuron methyl Methyl acetate Acetyl chloride L-PICEIN Thiophanate-methyl

p-Methyl-2-chloroacetophenone

2-Chloro-1-(4'-methylphenyl)ethanone

2-CHLORO-4'-METHYLACETOPHENONE

2-CHLORO-1-P-TOLYL-ETHANONE

A-CHLORO-4-METHYL ACETOPHENONE

4'-Methyl-2-chloroacetophenone

4-(2-chloroacetyl)toluene

Ethanone, 2-chloro-1-(4-methylphenyl)- (9CI)

Chloromethyl 4-methylphenyl ketone

CHLOROMETHYL P-TOLYL KETONE

p-Methylphenacyl chloride

α-Chloro-4'-methylacetophenone

2-chloro-1-(4-methylphenyl)ethan-1-one

Ethanone, 2-chloro-1-(4-methylphenyl)-

4209-24-9

409-24-9

C9H9OCl

Benzene series

ACETYLHALIDE