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2-Chloro-1-p-tolyl-ethanone

Product Name
2-Chloro-1-p-tolyl-ethanone
CAS No.
4209-24-9
Chemical Name
2-Chloro-1-p-tolyl-ethanone
Synonyms
4-(2-chloroacetyl)toluene;p-Methylphenacyl chloride;CHLOROMETHYL P-TOLYL KETONE;2-CHLORO-1-P-TOLYL-ETHANONE;p-Methyl-2-chloroacetophenone;4'-Methyl-2-chloroacetophenone;A-CHLORO-4-METHYL ACETOPHENONE;2-CHLORO-4'-METHYLACETOPHENONE;α-Chloro-4'-methylacetophenone;Chloromethyl 4-methylphenyl ketone
CBNumber
CB4322474
Molecular Formula
C9H9ClO
Formula Weight
168.62
MOL File
4209-24-9.mol
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2-Chloro-1-p-tolyl-ethanone Property

Melting point:
57.5°C
Boiling point:
238.18°C (rough estimate)
Density 
1.1115 (rough estimate)
refractive index 
1.5620 (estimate)
InChI
InChI=1S/C9H9ClO/c1-7-2-4-8(5-3-7)9(11)6-10/h2-5H,6H2,1H3
InChIKey
HGLJRZYKFVJSEE-UHFFFAOYSA-N
SMILES
C(=O)(C1=CC=C(C)C=C1)CCl
CAS DataBase Reference
4209-24-9(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

H313May be harmful in contact with skin

Precautionary statements

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

TRC
Product number
C374215
Product name
2-chloro-1-(4-methylphenyl)ethanone
Packaging
10mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
P247
Product name
4-(2-Chloroacetyl)toluene
Packaging
100mg
Price
$216
Updated
2021/12/16
AK Scientific
Product number
P247
Product name
4-(2-Chloroacetyl)toluene
Packaging
250mg
Price
$253
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0024009
Product name
CHLOROMETHYL P-TOLYL KETONE
Purity
95.00%
Packaging
1G
Price
$692.46
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0024009
Product name
CHLOROMETHYL P-TOLYL KETONE
Purity
95.00%
Packaging
2.5G
Price
$932.6
Updated
2021/12/16
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2-Chloro-1-p-tolyl-ethanone Chemical Properties,Usage,Production

Uses

2-chloro-1-(4-methylphenyl)ethanone (cas# 4209-24-9) can be used for preparation of acetophenone derivatives, which are known to be fungicides that control phytopathogenic fungi. In addition, this compound can be used for synthesis of clinafloxacin triazole hybrids, which are also known for the their antifungal and antibacterial activity. Moreover, this compound was found to inhibit (uncompetitively to ATP) pyruvate dehydrogenase (PDH), meaning it inhibits further glucose oxidation. That is why this compound can potentially be used to treat such conditions as diabetes and/or ischemia.

Preparation

To a suspension of anhydrous aluminum chloride (5.60 g, 40 mmol) in anhydrous toluene (40 mL), chloroacetyl chloride (4.52 g, 40 mmol) was slowly added dropwise.  After the aluminum chloride had dissolved, the mixture was heated slowly to 80 °C and held at that temperature for 2 h, then cooled and poured into crushed ice (100 g)containing concentrated hydrochloric acid (10 mL).  The reaction liquid is extracted by toluene, concentrated, and dried to obtain 2-Chloro-1-p-tolyl-ethanone.

Synthesis Reference(s)

Synthetic Communications, 20, p. 1625, 1990 DOI: 10.1080/00397919008053082

Hazard

Chloromethyl p-tolyl ketone is a danger compound.
H290 (33.33%): May be corrosive to metals [Warning Corrosive to Metals]
H302 (66.67%): Harmful if swallowed [Warning Acute toxicity, oral]
H314 (33.33%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
H315 (66.67%): Causes skin irritation [Warning Skin corrosion/irritation]
H318 (66.67%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
H319 (33.33%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H334 (66.67%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
H335 (66.67%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

2-Chloro-1-p-tolyl-ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-1-p-tolyl-ethanone Suppliers

China 45 Europe 3 Germany 1 India 1 Ukraine 2 United Kingdom 2 United States 16 Global 70
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View Lastest Price from 2-Chloro-1-p-tolyl-ethanone manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Chloromethyl p-tolyl ketone 4209-24-9
Price
US $1.00-35.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
15000KG
Release date
2024-08-08
Shanghai Xinchem Co., Ltd.
Product
Chloromethyl p-tolyl ketone 4209-24-9
Price
US $0.00-0.00/drums
Min. Order
1drums
Purity
99%min.
Supply Ability
10tons
Release date
2023-10-22

4209-24-9, 2-Chloro-1-p-tolyl-ethanoneRelated Search:

Trichloroacetyl chloride 4'-Hydroxyacetophenone 4-Nitroacetophenone 2-Bromoacetophenone METSULFURON METHYL 4'-Methylacetophenone Acetophenone Methyl acrylate Phenoxyacetyl chloride Vinylbenzyl chloride 4'-(Trifluoromethyl)acetophenone 4-(Chloromethyl)benzoic acid 3-Nitroacetophenone Bensulfuron methyl Methyl acetate Acetyl chloride L-PICEIN Thiophanate-methyl

  • p-Methyl-2-chloroacetophenone
  • 2-Chloro-1-(4'-methylphenyl)ethanone
  • 2-CHLORO-4'-METHYLACETOPHENONE
  • 2-CHLORO-1-P-TOLYL-ETHANONE
  • A-CHLORO-4-METHYL ACETOPHENONE
  • 4'-Methyl-2-chloroacetophenone
  • 4-(2-chloroacetyl)toluene
  • Ethanone, 2-chloro-1-(4-methylphenyl)- (9CI)
  • Chloromethyl 4-methylphenyl ketone
  • CHLOROMETHYL P-TOLYL KETONE
  • p-Methylphenacyl chloride
  • α-Chloro-4'-methylacetophenone
  • 2-chloro-1-(4-methylphenyl)ethan-1-one
  • Ethanone, 2-chloro-1-(4-methylphenyl)-
  • 4209-24-9
  • 409-24-9
  • C9H9OCl
  • Benzene series
  • ACETYLHALIDE