5-AMINO-2-FLUOROBENZYL ALCOHOL

Product Name: 5-AMINO-2-FLUOROBENZYL ALCOHOL
CAS No.: 84832-00-8
Chemical Name: 5-AMINO-2-FLUOROBENZYL ALCOHOL
Synonyms: (5-Amino-2-fluorophenyl);5-AMINO-2-FLUOROBENZYL ALCOHOL;5-Amino-2-fluorobenzylalcohol99%;5-Amino-2-fluorobenzyl alcohol 99%;Benzenemethanol, 5-amino-2-fluoro-;(5-AMINO-2-FLUORO-PHENYL)-METHANOL;5-AMINO-2-FLUOROBENZYL ALCOHOL ISO 9001：2015 REACH;(5-Amino-2-fluorophenyl)methanol, 4-Fluoro-3-(hydroxymethyl)aniline
CBNumber: CB4341817
Molecular Formula: C7H8FNO
Formula Weight: 141.14
MOL File: 84832-00-8.mol

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5-AMINO-2-FLUOROBENZYL ALCOHOL Property

Melting point:: 99-100°
Boiling point:: 295.4±25.0 °C(Predicted)
Density: 1.286±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 14.05±0.10(Predicted)
Appearance: Off-white to gray Solid

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2906290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A630308
Product name: (5-Amino-2-fluorophenyl)methanol
Packaging: 500mg
Price: $155
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4656-3-Y0
Product name: 5-Amino-2-fluorobenzyl alcohol
Purity: 99%
Packaging: 5G
Price: $168
Updated: 2021/12/16

Matrix Scientific

Product number: 047420
Product name: (5-Amino-2-fluorophenyl)methanol
Purity: 95+%
Packaging: 5g
Price: $179
Updated: 2021/12/16

ChemScene

Product number: CS-W021111
Product name: (5-Amino-2-fluorophenyl)methanol
Purity: >98.0%
Packaging: 10g
Price: $233
Updated: 2021/12/16

AK Scientific

Product number: 3074AC
Product name: (5-Amino-2-fluorophenyl)methanol
Packaging: 10g
Price: $394
Updated: 2021/12/16

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5-AMINO-2-FLUOROBENZYL ALCOHOL Chemical Properties,Usage,Production

Synthesis Reference(s)

Journal of Medicinal Chemistry, 33, p. 327, 1990 DOI: 10.1021/jm00163a053

Synthesis

63878-73-9

84832-00-8

2-Fluoro-5-nitrobenzyl alcohol (2.00 g, 11.9 mmol) was used as starting material and mixed with iron powder (3.72 g, 66.8 mmol) and hydrochloric acid (265.84 mg, 7.28 mmol). The mixture was heated under reflux conditions for 2 hours. After completion of the reaction, it was filtered through diatomaceous earth while hot and cooled to room temperature. Subsequently, the aqueous phase was alkalized with saturated sodium bicarbonate solution and extracted with dichloromethane (CH2Cl2). The organic layer was separated, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated by rotary evaporator to afford the brown solid crude product 5-amino-2-fluorobenzyl alcohol (1.51 g, 10.7 mmol, 90% yield). The product was identified by infrared spectroscopy (KBr), which showed that the absorption peaks were located at 3568, 3410, 2930, 1628, 1512, 1439, 1358, 1036, 874, 818, 737 cm-1 ; the 1H-NMR (CDCl3) spectrum showed the chemical shifts δ: 7.26 (broad single peak, 2H), 6.84 (triple peak, J = 9.2 Hz , 1H), 6.75-6.69 (multiple peaks, 1H), 6.61-6.50 (multiple peaks, 1H), 4.67 (single peak, 2H).

References

[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 7, p. 1828 - 1844
[2] Chemical and Pharmaceutical Bulletin, 2016, vol. 64, # 6, p. 594 - 601
[3] Journal of Medicinal Chemistry, 1990, vol. 33, # 1, p. 327 - 336
[4] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 5, p. 527 - 532
[5] Patent: WO2004/4720, 2004, A1. Location in patent: Page/Page column 76-77

5-AMINO-2-FLUOROBENZYL ALCOHOL Preparation Products And Raw materials

Raw materials

Preparation Products

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5-AMINO-2-FLUOROBENZYL ALCOHOL Suppliers

China 64 Germany 1 India 1 United Kingdom 2 United States 12 Global 80

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5-Amino-2-fluorobenzyl alcohol 99%

5-AMINO-2-FLUOROBENZYL ALCOHOL

(5-AMINO-2-FLUORO-PHENYL)-METHANOL

(5-Amino-2-fluorophenyl)methanol, 4-Fluoro-3-(hydroxymethyl)aniline

5-Amino-2-fluorobenzylalcohol99%

(5-Amino-2-fluorophenyl)

Benzenemethanol, 5-amino-2-fluoro-

5-AMINO-2-FLUOROBENZYL ALCOHOL ISO 9001：2015 REACH

84832-00-8

pharmacetical