ChemicalBook > CAS DataBase List > SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE

SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE

Product Name
SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE
CAS No.
7782-85-6
Chemical Name
SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE
Synonyms
DSP;DSP HEPTAHYDRATE;DISODIUM PHOSPHATE;SODIUM PHOSPHATE, DI;SODIUM PHOSPHATE DIBASIC;DIBASIC SODIUM PHOSPHATE;SECONDARY SODIUM PHOSPHATE;DISODIUM HYDROGEN PHOSPHATE;SODIUM PHOSPHATE HEPTAHYDRATE;MONOHYDROGEN SODIUM PHOSPHATE
CBNumber
CB4362537
Molecular Formula
H6NaO5P
Formula Weight
140.01
MOL File
7782-85-6.mol
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SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE Property

Melting point:
48 °C
Density 
1.68 g/mL at 25 °C(lit.)
bulk density
800kg/m3
vapor density 
4.9 (vs air)
storage temp. 
Store at +5°C to +30°C.
solubility 
154g/l
form 
Solid
color 
White
Specific Gravity
1.7
PH Range
8.7 - 9.3
PH
8.7-9.3 (25℃, 5% in solution)
Water Solubility 
Soluble in water and insoluble in ethanol.
Merck 
14,8659
LogP
-2.148 (est)
CAS DataBase Reference
7782-85-6(CAS DataBase Reference)
EPA Substance Registry System
Disodium phosphate heptahydrate (7782-85-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
2
RTECS 
WC4600000
TSCA 
Yes
HS Code 
28352990
Toxicity
LD50 orally in Rabbit: 12930 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S2429
Product name
Sodium phosphate dibasic heptahydrate
Purity
meets USP testing specifications
Packaging
250G
Price
$95.5
Updated
2024/03/01
Sigma-Aldrich
Product number
S2429
Product name
Sodium phosphate dibasic heptahydrate
Purity
meets USP testing specifications
Packaging
500G
Price
$128
Updated
2024/03/01
Sigma-Aldrich
Product number
S2429
Product name
Sodium phosphate dibasic heptahydrate
Purity
meets USP testing specifications
Packaging
1KG
Price
$236
Updated
2024/03/01
Sigma-Aldrich
Product number
S2429
Product name
Sodium phosphate dibasic heptahydrate
Purity
meets USP testing specifications
Packaging
3KG
Price
$540
Updated
2024/03/01
Sigma-Aldrich
Product number
8210-OP
Product name
OmniPur Sodium Phosphate, Dibasic, Heptahydrate - CAS 7782-85-6 - Calbiochem
Packaging
500g
Price
$76.3
Updated
2024/03/01
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SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE Chemical Properties,Usage,Production

Chemical Properties

The USP 32 states that dibasic sodium phosphate is dried or contains, 1, 2, 7, or 12 molecules of water of hydration. Anhydrous dibasic sodium phosphate occurs as a white powder. The dihydrate occurs as white or almost white, odorless crystals.
The heptahydrate occurs as colorless crystals or as a white granular or caked salt that effloresces in warm, dry air. The dodecahydrate occurs as strongly efflorescent, colorless or transparent crystals.

Uses

Buffering agent.

Uses

Sodium Phosphate Dibasic Heptahydrate is used as precursor in the preparation of cobalt-based molecular catalyst for water oxidation.

Uses

Sodium phosphate dibasic heptahydrate has been used to prepare sodium phosphate buffer and phosphate-buffered saline (PBS) buffer.[44}

Production Methods

Either bone phosphate (bone ash), obtained by heating bones to whiteness, or the mineral phosphorite is used as a source of tribasic calcium phosphate, which is the starting material in the industrial production of dibasic sodium phosphate.
Tribasic calcium phosphate is finely ground and digested with sulfuric acid. This mixture is then leached with hot water and neutralized with sodium carbonate, and dibasic sodium phosphate is crystallized from the filtrate.

Pharmaceutical Applications

Dibasic sodium phosphate is used in a wide variety of pharmaceutical formulations as a buffering agent and as a sequestering agent. Therapeutically, dibasic sodium phosphate is used as a mild laxative and in the treatment of hypophosphatemia.
Dibasic sodium phosphate is also used in food products; for example as an emulsifier in processed cheese.

Safety

Dibasic sodium phosphate is widely used as an excipient in parenteral, oral, and topical pharmaceutical formulations. Phosphate occurs extensively in the body and is involved in many physiological processes since it is the principal anion of intracellular fluid. Most foods contain adequate amounts of phosphate, making hypophosphatemia (phosphate deficiency) virtually unknown except for certain disease states or in patients receiving total parenteral nutrition. Treatment is usually by the oral administration of up to 100 mmol of phosphate daily.
Approximately two-thirds of ingested phosphate is absorbed from the gastrointestinal tract, virtually all of it being excreted in the urine, and the remainder is excreted in the feces.
Excessive administration of phosphate, particularly intravenously, rectally, or in patients with renal failure, can cause hyperphosphatemia that may lead to hypocalcemia or other severe electrolyte imbalances. Adverse effects occur less frequently following oral consumption, although phosphates act as mild saline laxatives when administered orally or rectally. Consequently, gastrointestinal disturbances including diarrhea, nausea, and vomiting may occur following the use of dibasic sodium phosphate as an excipient in oral formulations. However, the level of dibasic sodium phosphate used as an excipient in a pharmaceutical formulation is not usually associated with adverse effects.
LD50 (rat, oral): 17 g/kg

storage

The anhydrous form of dibasic sodium phosphate is hygroscopic. When heated to 40℃, the dodecahydrate fuses; at 100℃ it loses its water of crystallization; and at a dull-red heat (about 240℃) it is converted into the pyrophosphate, Na4P2O7. Aqueous solutions of dibasic sodium phosphate are stable and may be sterilized by autoclaving.
The bulk material should be stored in an airtight container, in a cool, dry place.

Incompatibilities

Dibasic sodium phosphate is incompatible with alkaloids, antipyrine, chloral hydrate, lead acetate, pyrogallol, resorcinol and calcium gluconate, and ciprofloxacin. Interaction between calcium and phosphate, leading to the formation of insoluble calcium-phosphate precipitates, is possible in parenteral admixtures.

Regulatory Status

GRAS listed. Accepted in Europe for use as a food additive. Included in the FDA Inactive Ingredients Database (injections; infusions; nasal, ophthalmic, oral, otic, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE Suppliers

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View Lastest Price from SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE manufacturers

Aurora Industry Co., Ltd.
Product
Di sodium Phosphate (DSP) 7782-85-6
Price
US $800.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
1000 tons
Release date
2024-09-06
Shaanxi Dideu Medichem Co. Ltd
Product
Sodium phosphate dibasic heptahydrate 7782-85-6
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50ton
Release date
2020-05-20
Hebei Yime New Material Technology Co., Ltd.
Product
SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE 7782-85-6
Price
US $20.00/KG
Min. Order
2KG
Purity
99%
Supply Ability
10000 kilograms/ month
Release date
2021-06-01

7782-85-6, SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATERelated Search:

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