2-(3,4-dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide

Product Name: 2-(3,4-dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide
CAS No.: 1486482-16-9
Chemical Name: 2-(3,4-dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide
Synonyms: ML251;2-(3,4-dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide;2-(3,4-Dichlorophenyl)-N-(4-(N-(isoxazol-3-yl)sulfamoyl)phenyl)acetamide;cruzi,inhibit,brucei,MRC-5,Inhibitor,nanomolar,Parasite,ML-251,ML 251,ML251
CBNumber: CB43839951
Molecular Formula: C17H13Cl2N3O4S
Formula Weight: 426.27382
MOL File: 1486482-16-9.mol

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2-(3,4-dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide Property

storage temp.: Store at -20°C
solubility: DMSO : 250 mg/mL (586.48 mM; Need ultrasonic)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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2-(3,4-dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide Chemical Properties,Usage,Production

Biological Activity

ML251, a potent nanomolar T. brucei and T. cruzi phosphofructokinase (PFK) inhibitor, inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite[1]. ML251 (T. brucei; 0~33.3 μg/mL) produces modest dose-dependent toxicity[1].

References

[1]. Brimacombe KR, et al. Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase. ACS Med Chem Lett. 2013;5(1):12-17.

2-(3,4-dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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1486482-16-9, 2-(3,4-dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamideRelated Search:

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2-(3,4-dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide

ML251

2-(3,4-Dichlorophenyl)-N-(4-(N-(isoxazol-3-yl)sulfamoyl)phenyl)acetamide

cruzi,inhibit,brucei,MRC-5,Inhibitor,nanomolar,Parasite,ML-251,ML 251,ML251

1486482-16-9