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GAMMA-SECRETASE INHIBITOR

Product Name
GAMMA-SECRETASE INHIBITOR
CAS No.
133407-83-7
Chemical Name
GAMMA-SECRETASE INHIBITOR
Synonyms
IN1097;Z-LLNLE-CHO;Z-LEU-LEU-NLE-CHO;Z LLNle CHO,ZLLNleCHO;Z-LEU-LEU-NLE-ALDEHYDE;γ-Secretase Inhibitor I;γ–Secretase Inhibitor I;CBZ-Leu-Leu-Nle-Aldehyde;GAMMA-SECRETASE INHIBITOR;GAMMA-SECRETASE INHIBITOR I
CBNumber
CB4394833
Molecular Formula
C26H41N3O5
Formula Weight
475.62
MOL File
133407-83-7.mol
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GAMMA-SECRETASE INHIBITOR Property

storage temp. 
−20°C
solubility 
DMSO: soluble
form 
powder
color 
White to off-white
Sensitive 
Hygroscopic
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
565750
Product name
γ-Secretase Inhibitor I
Purity
The γ-Secretase Inhibitor I controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
Packaging
1MG
Price
$176
Updated
2025/07/31
TRC
Product number
S241008
Product name
γ-SecretaseInhibitorI
Packaging
10mg
Price
$370
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0000969
Product name
GAMMA-SECRETASE INHIBITOR
Purity
95.00%
Packaging
1MG
Price
$894.4
Updated
2021/12/16
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GAMMA-SECRETASE INHIBITOR Chemical Properties,Usage,Production

Uses

gamma-Secretase Inhibitor I is a γ-secretase inhibitor.

Biological Activity

Cell permeable: yes', 'Primary Target
γ-secretase', 'Product does not compete with ATP.', 'Reversible: no

in vivo

Z-LLNle-CHO (5 mg/kg; s.c.; single daily for 12 days) inhibits engraftment of B-lymphoblasts in precursor-B ALL xenograft model[2].

Animal Model:Female SCID/NOD mice (6-8-week-old; precursor-B ALL xenograft model)[2].
Dosage:5 mg/kg
Administration:Subcutaneous injection; single daily for 12 days
Result:Delayed or prevented engraftment of B-lymphoblasts in 50% of the animals comprising the experimental group.

GAMMA-SECRETASE INHIBITOR Preparation Products And Raw materials

Raw materials

Preparation Products

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GAMMA-SECRETASE INHIBITOR Suppliers

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133407-83-7, GAMMA-SECRETASE INHIBITORRelated Search:

DAPT DIBENZAZEPINE γ-Secretase Inhibitor XXI BETA-SECRETASE INHIBITOR IV N-Cbz-D-glutamic acid alpha-benzyl ester N-Carbobenzyloxy-L-alanine Z-D-ASP(OTBU)-OH H2O Z-NVA-OH Z-PHE-ALA-DIAZOMETHYLKETONE Z-SAR-OH GAMMA-SECRETASE INHIBITOR XVI GAMMA-SECRETASE INHIBITOR XV GAMMA-SECRETASE INHIBITOR XVII GAMMA-SECRETASE INHIBITOR XI GAMMA-SECRETASE INHIBITOR VII GAMMA-SECRETASE INHIBITOR X GAMMA-SECRETASE INHIBITOR XVIII GAMMA-SECRETASE INHIBITOR XIX

  • Z-LEU-LEU-NLE-ALDEHYDE
  • Z-LEU-LEU-NLE-CHO
  • Z-LLNLE-CHO
  • GAMMA-SECRETASE INHIBITOR
  • GAMMA-SECRETASE INHIBITOR I
  • Cbz-leucinyl-leucinyl-norleucinal
  • γ-Secretase Inhibitor I
  • L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formylpentyl]-
  • benzyl N-[4-methyl-1-[[4-methyl-1-oxo-1-(1-oxohexan-2-ylamino)pentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
  • CBZ-Leu-Leu-Nle-Aldehyde
  • Z LLNle CHO,ZLLNleCHO
  • Benzyl ((S)-4-methyl-1-(((S)-4-methyl-1-oxo-1-(((S)-1-oxohexan-2-yl)amino)pentan-2-yl)amino)-1-oxopentan-2-yl)carbamate
  • γ–Secretase Inhibitor I
  • IN1097
  • 133407-83-7
  • C33H57F2N5O9
  • Biochemicals and Reagents
  • BioChemical
  • R to Z
  • gamma Secretase
  • Enzyme Inhibitors
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Enzyme
  • Alzheimers and Neurodegenerative Disease Research
  • gamma SecretaseNeurobiology
  • Neurodegenerative Disease Peptides
  • Other Alzheimer Peptides
  • Protease Inhibitor Specificity Index
  • Protease Inhibitors
  • R to
  • γSecretaseEnzyme Inhibitors by Enzyme
  • OtherNeuropeptides
  • Z-Leu-Leu-Nle-CHO
  • Pepetides
  • peptides