ChemicalBook > CAS DataBase List > 3-Nitroacetophenone

3-Nitroacetophenone

Product Name
3-Nitroacetophenone
CAS No.
121-89-1
Chemical Name
3-Nitroacetophenone
Synonyms
1-(3-NITROPHENYL)ETHANONE;M-NITROACETOPHENONE;(3-nitrophenyl)methylketone;usafma-1;USAF ma-1;AKOS 233-65;AURORA 14018;AKOS BBS-00003220;3-Nitroacetofenon;3-NITROACETOPHENONE
CBNumber
CB4400448
Molecular Formula
C8H7NO3
Formula Weight
165.15
MOL File
121-89-1.mol
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3-Nitroacetophenone Property

Melting point:
76-78 °C(lit.)
Boiling point:
202 °C(lit.)
Density 
1.3450 (rough estimate)
vapor pressure 
0.32Pa at 25℃
refractive index 
1.5468 (estimate)
Flash point:
202°C
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Crystalline Powder
color 
Yellow to yellow-green
Odor
Odorless
Water Solubility 
<0.01 g/100 mL at 20 ºC
BRN 
743002
Stability:
Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKey
ARKIFHPFTHVKDT-UHFFFAOYSA-N
LogP
1.42
NIST Chemistry Reference
3-Nitroacetophenone(121-89-1)
EPA Substance Registry System
3-Nitroacetophenone (121-89-1)
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Safety

Hazard Codes 
Xn
Risk Statements 
21
Safety Statements 
22-24/25
WGK Germany 
2
RTECS 
AM9625000
TSCA 
Yes
HS Code 
29147090
Hazardous Substances Data
121-89-1(Hazardous Substances Data)
Toxicity
mouse,LD50,intraperitoneal,200mg/kg (200mg/kg),National Technical Information Service. Vol. AD277-689,
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
72610
Product name
3′-Nitroacetophenone
Purity
purum, ≥98.0% (GC)
Packaging
100g
Price
$35.5
Updated
2024/03/01
TCI Chemical
Product number
N0109
Product name
3'-Nitroacetophenone
Purity
>98.0%(GC)
Packaging
25g
Price
$25
Updated
2024/03/01
TCI Chemical
Product number
N0109
Product name
3'-Nitroacetophenone
Purity
>98.0%(GC)
Packaging
100g
Price
$57
Updated
2024/03/01
Alfa Aesar
Product number
A12155
Product name
3'-Nitroacetophenone, 98+%
Packaging
250g
Price
$71.65
Updated
2024/03/01
Alfa Aesar
Product number
A12155
Product name
3'-Nitroacetophenone, 98+%
Packaging
500g
Price
$122.65
Updated
2024/03/01
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3-Nitroacetophenone Chemical Properties,Usage,Production

Chemical Properties

white to light beige crystalline powder or yellow needle-like crystals. soluble in hot water and ether, slightly soluble in ethanol. can be volatile with water vapor.

Uses

3''-Nitroacetophenone is used as a reactant in the synthesis of fluorine based aminothiazoles with antimicrobial activity.

Uses

3′-Nitroacetophenone can undergo high hydrostatic pressure-assisted reduction with Ni–Al alloy in water to form 1-(3-aminophenyl)ethanol.

Preparation

3-Nitroacetophenone is synthesized from acetophenone by nitration.
Synthesis of 3-nitroacetophenone

Production Methods

Acetophenone is carefully dissolved in concentrated sulfuric acid at 0 ℃, and mixed acid is added slowly below 0 ℃. The crude product is precipitated by quenching into ice, filtered, and washed acid free. Purification, mainly from the ortho isomer, is achieved by recrystallization from ethanol with significant lowering of the overall yield to ca. 55 %.

General Description

3-nitroacetophenone is a light beige powder. It is an anthropogenic compound which is used as a synthetic intermediate in the production of dyes and other organic compounds. (NTP, 1992)

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A nitrated ketone. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.

Fire Hazard

Flash point data for 3-Nitroacetophenone are not available, however 3-Nitroacetophenone is probably combustible.

Purification Methods

Distil the ketone in steam and crystallise it from EtOH. [Beilstein 7 IV 656.]

3-Nitroacetophenone Preparation Products And Raw materials

Raw materials

2-Nitroacetophenone

Preparation Products

ETHYL 5-(3-NITROPHENYL)-1H-PYRAZOLE-3-CARBOXYLATE 3-ACETYLBENZONITRILE APLPHA-BROMO-M-BENZOYLOXYACETOPHENONE 5-(3-NITRO-PHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID 3-Aminoacetophenone
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3-Nitroacetophenone Suppliers

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View Lastest Price from 3-Nitroacetophenone manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
3-Nitroacetophenone 121-89-1
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-11-15
Hebei Weibang Biotechnology Co., Ltd
Product
3-Nitroacetophenone 121-89-1
Price
US $0.00-0.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25
airuikechemical co., ltd.
Product
3-nitroacetophenone 121-89-1
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-08

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