ChemicalBook > CAS DataBase List > RUSCOGENIN

RUSCOGENIN

Product Name
RUSCOGENIN
CAS No.
472-11-7
Chemical Name
RUSCOGENIN
Synonyms
RUSCOGENINE;HeModren;FlebopoM;Ruscogeni;RUSCOGENIN;Rectolander;Ruscorectal;RUSCOGENIN(P);Ruscogenins CRS;RUSCOGENIN USP/EP/BP
CBNumber
CB4411307
Molecular Formula
C27H42O4
Formula Weight
430.63
MOL File
472-11-7.mol
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RUSCOGENIN Property

Melting point:
198-202℃
Boiling point:
563.1±50.0 °C(Predicted)
Density 
1.18
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka
14.56±0.70(Predicted)
form 
Solid
color 
White
InChIKey
QMQIQBOGXYYATH-ORLFXEBYNA-N
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Safety

Safety Statements 
24/25
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SMB00295
Product name
Ruscogenin
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$330
Updated
2025/07/31
Cayman Chemical
Product number
25217
Product name
Ruscogenin
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
25217
Product name
Ruscogenin
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
25217
Product name
Ruscogenin
Purity
≥98%
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
25217
Product name
Ruscogenin
Purity
≥98%
Packaging
25mg
Price
$533
Updated
2024/03/01
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RUSCOGENIN Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

A major steroidal sapogenin from Radix ophiopogon japonicus with robust anti-inflammatory and anti-thrombotic activities. Studies suggest that it inhibits adhesion of leukocytes to a human umbilical vein endothelial cell line (ECV304) injured by tumor necrosis factor-α (TNF-α) in a concentration-dependent manner.

Definition

ChEBI: Ruscogenin is a triterpenoid.

Biological Activity

Ruscogenin is a well-known compound for down-regulating nuclear factor kappa B (NF-KB), intercellular adhesion molecule-1 (ICAM-1), tissue factor (TF), inducible NO synthase (iNOS), and modulating inflammatory pathways. It displays anti-inflammatory properties by inhibiting lipopolysaccharide (LPS)-induced acute lung injury (ALI), and improving diabetic nephropathy in in vivo studies. Ruscogenin also exerts neuroprotective properties and protects the brain against ischemic injury in mouse model. It elicits anti-tumor properties by inducing ferroptosis in pancreatic cancer cells in both in vitro and in vivo studies.

target

PGE | TNF-α | NF-kB | p65 | NO | NOS | COX | ERK | JNK | Akt | p38MAPK | PKA | cAMP | IL Receptor

RUSCOGENIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from RUSCOGENIN manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
RUSCOGENIN 472-11-7
Price
US $1.00-45.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
2000KG
Release date
2024-08-01
Shanghai Standard Technology Co., Ltd.
Product
Ruscogenin 472-11-7
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-10-31
Career Henan Chemical Co
Product
RUSCOGENIN 472-11-7
Price
US $1.00/kg
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-25

472-11-7, RUSCOGENINRelated Search:

Centella asiatica extract 3-(1,3-Benzodioxol-5-ylmethyl)-3,4-dihydro-5,7-dihydroxy-8-methyl-4-oxo-2H-1-benzopyran-6-carboxaldehyde Ophiopogonanone B Ophiopogonis Extract Diosgenin FORSYTHIN lithospermic acid B AURANTIO-OBTUSIN SENEGENIN Ophiopogonin A RUSCOGENIN NEORUSCOGENIN ophiopogonin B S-Ruscogenin,(25S)-Ruscogenin OPHIOPOGONIN D OPHIOPOGONIN C ruscogenin-1-yl xylopyranosyl-1-3-(glucopyranosyl-1-2)fucopyranoside RUSCOGENIN(PRIMARY STANDARD)

  • FlebopoM
  • HeModren
  • Rectolander
  • Ruscogenin, froM Ophiopogon japonicus
  • (1B,3B,25R)-SPIROST-5-ENE-1,3-DIOL
  • RUSCOGENIN
  • RUSCOGENINE
  • (25R)-spirost-5-ene-1-beta,3-beta-diol
  • Spirost-5-ene-1,3-diol, (1.beta.,3.beta.,25R)-
  • RUSCOGENIN(P)
  • (1beta,3beta,25R)-Spirost-5-ene-1,3-diol
  • (1β,3β,25R)-Spirost-5-ene-1,3-diol
  • 25D-Spirost-5-ene-1β,3β-diol
  • Ruscogenin, 98%, from Ophiopogon japonicus (Thunb.) Ker Gawl.
  • (25R)-Spirost-5-ene-1β,3β-diol
  • Ruscorectal
  • Ruscogenins CRS
  • Spirost-5-ene-1,3-diol, (1β,3β,25R)-
  • RUSCOGENIN USP/EP/BP
  • Ruscogeni
  • Ruscogenin (6CI, 7CI)
  • Ruscogenin, 10 mM in DMSO
  • (1β,3β,25R)-Spirost-5-ene-1,3-diol
  • (4R,5'R,6R,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-Tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4,6-diol
  • 472-11-7
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  • standardized herbal extract