2-Bromo-4'-nitroacetophenone

Product Name: 2-Bromo-4'-nitroacetophenone
CAS No.: 99-81-0
Chemical Name: 2-Bromo-4'-nitroacetophenone
Synonyms: 2-BROMO-1-(4-NITROPHENYL)ETHAN-1-ONE;2-BROMO-1-(4-NITROPHENYL)ETHANONE;P-NITROPHENACYL BROMIDE;-bromo-4’ASISCHEM D48949;1,3-Bis(2’AKOS BBS-00003952;4-Nitrophecyl bromide;-cyano-phenoxy)propane;4-NITROPHENACYL BROMIDE
CBNumber: CB4426103
Molecular Formula: C8H6BrNO3
Formula Weight: 244.04
MOL File: 99-81-0.mol

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2-Bromo-4'-nitroacetophenone Property

Melting point:: 94-99 °C(lit.)
Boiling point:: 325.2±17.0 °C(Predicted)
Density: 1.8033 (rough estimate)
refractive index: 1.6090 (estimate)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: Crystalline Powder
color: Yellow to orange
BRN: 393567
InChI: InChI=1S/C8H6BrNO3/c9-5-8(11)6-1-3-7(4-2-6)10(12)13/h1-4H,5H2
InChIKey: MBUPVGIGAMCMBT-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=C([N+]([O-])=O)C=C1)CBr
CAS DataBase Reference: 99-81-0(CAS DataBase Reference)
NIST Chemistry Reference: p-Nitrophenacyl bromide(99-81-0)
EPA Substance Registry System: 2-Bromo-4'-nitroacetophenone (99-81-0)

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Safety

Hazard Codes: C,Xi
Risk Statements: 34-37
Safety Statements: 26-36/37/39-45
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
F: 19
Hazard Note: Irritant
TSCA: Yes
HazardClass: 8
PackingGroup: III
HS Code: 29147000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 245615
Product name: 2-Bromo-4′-nitroacetophenone
Purity: 95%
Packaging: 10g
Price: $84.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: 245615
Product name: 2-Bromo-4′-nitroacetophenone
Purity: 95%
Packaging: 50g
Price: $133.7
Updated: 2025/07/31

TCI Chemical

Product number: N0473
Product name: 2-Bromo-4'-nitroacetophenone
Purity: >98.0%(GC)
Packaging: 5g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: N0473
Product name: 2-Bromo-4'-nitroacetophenone
Purity: >98.0%(GC)
Packaging: 25g
Price: $32
Updated: 2025/07/31

TCI Chemical

Product number: N0473
Product name: 2-Bromo-4'-nitroacetophenone
Purity: >98.0%(GC)
Packaging: 100g
Price: $116
Updated: 2025/07/31

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2-Bromo-4'-nitroacetophenone Chemical Properties,Usage,Production

Chemical Properties

yellow to orange crystalline powder

Uses

2-Bromo-4′-nitroacetophenone was used to study the pKa of the histidine-34 imidazole.

Synthesis Reference(s)

Synthesis, p. 487, 1980 DOI: 10.1055/s-1980-29067

Synthesis

940-13-6

99-81-0

The general procedure for the synthesis of 2-bromo-4'-nitroacetophenone using the compound (CAS: 940-13-6) as starting material: haloalkynes (0.5 mmol), AgF (5 mol%), and water (1 eq.) were dissolved in trifluoroacetic acid (TFA, 1 mL), and the reaction was stirred for 6 hr at 40 °C. Upon completion of the reaction, TFA was recovered by distillation for reuse. The residue was purified by column chromatographic separation to afford the target product 2-bromo-4'-nitroacetophenone in pure form.

Purification Methods

Crystallise it from *C6H6/pet ether. [Beilstein 7 IV 661.]

References

[1] Tetrahedron Letters, 2014, vol. 55, # 7, p. 1373 - 1375
[2] Chinese Journal of Chemistry, 2016, vol. 34, # 12, p. 1251 - 1254
[3] Tetrahedron Letters, 2016, vol. 57, # 45, p. 4983 - 4986

2-Bromo-4'-nitroacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Bromo-4'-nitroacetophenone manufacturers

Henan Fengda Chemical Co., Ltd

Product: 2-Bromo-4'-nitroacetophenone 99-81-0
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-25

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Bromo-4'-nitroacetophenone 99-81-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 100 tons
Release date: 2020-01-07

Career Henan Chemical Co

Product: 2-Bromo-4'-nitroacetophenone 99-81-0
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2018-08-15

99-81-0, 2-Bromo-4'-nitroacetophenoneRelated Search:

Acetophenone 2',4'-Dichloroacetophenone 4'-Bromoacetophenone Ethidium bromide Clidinium bromide 2-Nitroacetophenone Bromonitromethane ACETOPHENONE-D8 PIPERACETAZINE (250 MG) Sodium bromate 2-Bromoacetophenone p-Nitrophenylacetonitrile 4-Nitroacetophenone 3-Nitroacetophenone 3-Bromoanisole 2-Bromo-4'-methoxyacetophenone 4-Chloro-2'-bromoacetophenone 2-Bromo-4'-chloroacetophenone

ASISCHEM D48949

4'-NITROPHENACYL BROMIDE

4-NITROPHENACYL BROMIDE

AKOS BBS-00003952

ALPHA-BROMO-P-NITROACETOPHENONE

ALPHA-BROMO-4-NITROACETOPHENONE

A-BROMO-P-NITROACETOPHENONE

2-BROMO-4'-NITROACENTOPHENONE

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2-BroMo-4'-nitroacetophenone 95%

α- broMo Nitroacetophenone

4-Nitrophecyl bromide

2-BROMO-1-(4-NITROPHENYL)ETHAN-1-ONE

2-BROMO-1-(4-NITROPHENYL)ETHANONE

2-Bromo-p-nitroacetophenone

4'-Nitro-2-bromoacetophenone

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Ethanone, 2-bromo-1-(4-nitrophenyl)-

omega-Bromo-p-nitroacetophenone

p-Nitro-alpha-bromoacetophenone

OMEGA-BROMO-4-NITROACETOPHENONE

P-NITROPHENACYL BROMIDE

2-Bromo-4'-Nitroacetophenone 4'-Nitrophenacyl Bromide 2-Bromo-1-(4-Nitrophenyl)ethan-1-one

A-BROMO-4-NITROACETOPHENONE

à-bromo-4-nitroacetophenone

ω-bromo-4-nitroacetophenone

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2-Bromo-4'-nitroacetophenone ,98%

4'-Nitro-ω-bromoacetophenone

2-Bromo-4'-nitroacetophenone,95%

2-Bromo-4′-nitroacetophenone,ω-Bromo-4-nitroacetophenone, 4-Nitrophenacyl bromide

2-Bromo-1-(4-nitrophenyl)ethan-1-one, TECH

-methoxyacetophenone, 97.0 +%

1,3-Bis(2&rsquo

-cyano-phenoxy)propane

4-Nitrophenacyl bromide 98%

-(imidazol-1-yl)acetophenone

2-Bromo-4'-nitroacetophenone&gt

2-Bromo-4'-nitroacetophenone, 98%, for synthesis

α-Bromo-4-nitroacetophenone

2-Bromo-4'-nitroacetophenone ISO 9001：2015 REACH

2-Bromo-4'-nitroacetophenone

2-Bromo-4′-nitroacetophenone, CAS 99-81-0

2-Bromo-4'-nitroacetophenone

99-81-0

C8H6BrNO3

O2NC6H4COCH2Br

Ketones

Organic Building Blocks

KETONE

Building Blocks

C7 to C8

Carbonyl Compounds

B

Bioactive Small Molecules