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Z-VAL-NH2

Product Name
Z-VAL-NH2
CAS No.
13139-28-1
Chemical Name
Z-VAL-NH2
Synonyms
Z-VAL-NH2;Z-L-Val-NH2;CBZ-Val-NH2;Cbz-L-Val-NH2;Z-L-VALINE AMIDE;CBZ-L-VALINE AMIDE;N-Cbz-L-valinamide;Z-VAL-NH2 USP/EP/BP;Benzyloxycarbonyl-L-valinamide;N-Benzyloxycarbonylvaline amide
CBNumber
CB4438832
Molecular Formula
C13H18N2O3
Formula Weight
250.29
MOL File
13139-28-1.mol
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Z-VAL-NH2 Property

Boiling point:
452.2±38.0 °C(Predicted)
Density 
1.144±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
form 
Solid
pka
11.09±0.46(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
V963035
Product name
Z-Val-NH2
Packaging
50mg
Price
$60
Updated
2021/12/16
Usbiological
Product number
292018
Product name
Z-L-valine amide
Packaging
2g
Price
$347
Updated
2021/12/16
AK Scientific
Product number
Z9569
Product name
Z-Val-NH2
Packaging
25g
Price
$145
Updated
2021/12/16
AK Scientific
Product number
J97114
Product name
Z-Val-NH2
Packaging
100g
Price
$338
Updated
2021/12/16
SynQuest Laboratories
Product number
4656-1-SD
Product name
Benzyl (S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamate; (S)-N-(Benzyloxycarbonyl)valinamide
Packaging
500mg
Price
$104
Updated
2021/12/16
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Z-VAL-NH2 Chemical Properties,Usage,Production

Synthesis

1149-26-4

13139-28-1

The general procedure for the synthesis of benzyl (S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamate from CBZ-L-valine was as follows: to a solution of compound I (10 g, 39.84 mmol, 1 eq.) in DMF (100 mL) at 0 °C was added sequentially DIPEA (19.7 mL, 119.5 mmol, 3 eq. ) and HATU (18.17 g, 47.8 mmol, 1.2 eq.). The reaction mixture was stirred for 15 minutes. Subsequently, ammonium chloride (10.7 g, 199.2 mmol, 5 eq.) was added to the mixture and the reaction mixture was continued to be stirred at 23 °C for 16 hours. Upon completion of the reaction, the mixture was poured into ice-cold water (500 mL) and the organic components were extracted with EtOAc (3 x 500 mL). The combined organic layers were washed sequentially with aqueous ammonium chloride and brine, then dried over anhydrous sodium sulfate, filtered and concentrated to dryness. The crude product was purified by ethanol recrystallization to afford the target product (S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamic acid benzyl ester (9.8 g, 98% yield) as an off-white solid. The product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 7.35 (m, 6H), 7.12 (d, 1H, J = 9Hz), 7.01 (s, 1H), 5.03 (s, 2H), 3.80 (t, 1H, J = 8Hz), 1.95 (m, 1H), 0.85 (m, 6H).LCMS analysis: m/z = 251.2 [M + H], retention time RT = 2.81 min (program P1, column Y).

References

[1] Patent: WO2015/95128, 2015, A1. Location in patent: Paragraph 0195; 0196; 0197
[2] Tetrahedron Asymmetry, 2017, vol. 28, # 12, p. 1690 - 1699
[3] Chemische Berichte, 1983, vol. 116, # 5, p. 2037 - 2040
[4] Tetrahedron Letters, 1995, vol. 36, # 39, p. 7115 - 7118
[5] Chemical Communications, 2017, vol. 53, # 75, p. 10362 - 10365

Z-VAL-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-VAL-NH2 Suppliers

China 59 Germany 1 India 2 Japan 1 Switzerland 1 United Kingdom 1 United States 8 Global 73
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
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View Lastest Price from Z-VAL-NH2 manufacturers

Career Henan Chemical Co
Product
Z-VAL-NH2 13139-28-1
Price
US $1.00/KG
Min. Order
1KG
Purity
95%-99.99%
Supply Ability
1kg-10MT
Release date
2019-05-24

13139-28-1, Z-VAL-NH2Related Search:

Z-VAL-PHE-OH Z-VAL-OSU Z-VAL-GLY-OH Z-VAL-ONP Z-VAL-PRO-OH N-Carbobenzyloxy-L-valine Z-TYR-OH Z-TLE-OH DCHA Z-TRP-OME Z-TYR(TBU)-OSU Z-TYR-ONP Z-TYR-OME Z-L-Valine NCA Z-VAL-OET Z-VAL-PHE-OME Z-VAL-ALA-OH Z-VAL-SER-OH CBZ-L-VALINE METHYL ESTER

  • N-Benzyloxycarbonyl-L-valinamide
  • N-Benzyloxycarbonylvaline amide
  • Benzyloxycarbonyl-L-valinamide
  • (S)-N-Benzoyloxycarbonyl valinamide
  • Z-L-Val-NH2
  • N-ALPHA-CARBOBENZOXY-L-VALINE AMIDE
  • Z-L-VALINE AMIDE
  • Z-VAL-NH2
  • CBZ-L-VALINE AMIDE
  • (S)-benzyl 1-amino-3-methyl-1-oxobutan-2-ylcarbamate
  • CBZ-Val-NH2
  • (S)-N-(Benzyloxycarbonyl)valinamide
  • Benzyl(S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamate
  • benzyl N-[(1S)-1-carbamoyl-2-methylpropyl]carbamate
  • N-Cbz-L-valinamide
  • Carbamic acid, N-[(1S)-1-(aminocarbonyl)-2-methylpropyl]-, phenylmethyl ester
  • benzylN-[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]carbamate
  • Z-VAL-NH2 USP/EP/BP
  • Cbz-L-Val-NH2
  • 13139-28-1