ChemicalBook > CAS DataBase List > 1-Methyl-2-pyrrolidineethanol

1-Methyl-2-pyrrolidineethanol

Product Name: 1-Methyl-2-pyrrolidineethanol
CAS No.: 67004-64-2
Chemical Name: 1-Methyl-2-pyrrolidineethanol
Synonyms: Clemastine Impurity 4;Clemastine Impurity D;Clemastine EP Impurity D;1-METHYL-2-PYRROLIDINEETHANOL;N-METHYL-2-PYRROLIDINEETHANOL;HYDROXYETHYLMETHYLPYRROLIDINE;1-Methylpyrrolidine-2-Ethanol;N-Methyl-2-ethanol-pyrrolidine;2-(2-Hydroxyethyl)-N-Methyl-Py;2-PYRROLIDINEETHANOL, 1-METHYL-
CBNumber: CB4441351
Molecular Formula: C7H15NO
Formula Weight: 129.2
MOL File: 67004-64-2.mol

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1-Methyl-2-pyrrolidineethanol Property

Boiling point:: 110-112 °C14 mm Hg(lit.)
Density: 0.951 g/mL at 25 °C(lit.)
refractive index: n20/D 1.4713(lit.)
Flash point:: 184 °F
storage temp.: 2-8°C(protect from light)
form: clear liquid
pka: 15.03±0.10(Predicted)
color: Colorless to Red to Green
InChI: InChI=1S/C7H15NO/c1-8-5-2-3-7(8)4-6-9/h7,9H,2-6H2,1H3
InChIKey: FYVMBPXFPFAECB-UHFFFAOYSA-N
SMILES: N1(C)CCCC1CCO
CAS DataBase Reference: 67004-64-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-38-41
Safety Statements: 26-39
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BP526
Product name: 2-(2-Hydroxyethyl)-1-methylpyrrolidine
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $234
Updated: 2025/07/31

Sigma-Aldrich

Product number: 139513
Product name: 1-Methyl-2-pyrrolidine ethanol
Purity: 98%
Packaging: 5g
Price: $59
Updated: 2025/07/31

Sigma-Aldrich

Product number: 139513
Product name: 1-Methyl-2-pyrrolidine ethanol
Purity: 98%
Packaging: 25g
Price: $261
Updated: 2023/01/07

TCI Chemical

Product number: M0908
Product name: 2-(2-Hydroxyethyl)-1-methylpyrrolidine
Purity: >98.0%(GC)(T)
Packaging: 10mL
Price: $86
Updated: 2025/07/31

TCI Chemical

Product number: M0908
Product name: 2-(2-Hydroxyethyl)-1-methylpyrrolidine
Purity: >98.0%(GC)(T)
Packaging: 25mL
Price: $165
Updated: 2025/07/31

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1-Methyl-2-pyrrolidineethanol Chemical Properties,Usage,Production

Chemical Properties

clear yellow to brownish liquid

Uses

2-(2-Hydroxyethyl)-1-methylpyrrolidine BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.
Also used in monographs such as:

Clemastine Tablets

General Description

1-Methyl-2-pyrrolidine ethanol is an important pharmaceutical intermediate.

Synthesis

51856-76-9

67004-64-2

The general procedure for the synthesis of N-methyl-2-(2-hydroxyethyl)pyrrolidine from methyl 1-methylpyrrolidine-2-acetate was as follows: 5.0 g of intermediate 2 was weighed and placed in a round-bottomed flask, and 50 mL of methanol was added to dissolve it. Subsequently, 2.0 g NaBH4 was slowly added to the reaction system, heated to reflux and kept for 12 hours. After completion of the reaction, methanol was removed by rotary evaporation under reduced pressure. To the residue, 50 mL of ethyl acetate (EA) and 50 mL of water were added, transferred to a dispensing funnel, and the organic layer was separated by sufficiently shaking and standing to separate the layers. The organic layer was washed with saturated saline and dried with anhydrous sodium sulfate. After filtration to remove the desiccant, the organic solvent was concentrated under reduced pressure to obtain 3.5 g of the target product N-methyl-2-(2-hydroxyethyl)pyrrolidine in the form of a colorless liquid.

References

[1] Patent: KR2016/141950, 2016, A. Location in patent: Paragraph 0037

1-Methyl-2-pyrrolidineethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-Methyl-2-pyrrolidineethanol manufacturers

Chongqing Soarwin Technology Co., Ltd

Product: 1-Methyl-2-pyrrolidineethanol 67004-64-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2025-04-11

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1-Methyl-2-pyrrolidineethanol 67004-64-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-28

SHANDONG OUCHEM CO.,LTD.

Product: 1-Methyl-2-pyrrolidineethanol 67004-64-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98% Min.
Supply Ability: 2000KG
Release date: 2024-11-03

67004-64-2, 1-Methyl-2-pyrrolidineethanolRelated Search:

SCOPOLAMINE N-OXIDE HYDROBROMIDE ATROPINE METHYL NITRATE HYOSCINE HYDROCHLORIDE RETRORSINE Tropine COCAINE HYDROCHLORIDE 1-Methyl-2-pyrrolidineethanol HOMATROPINE METHYL BROMIDE Homatropine Hydrobromide Scopine hydrochloride HARRINGTONINE Atropine COCAINE Scopolamine hydrobromide ATROPINE METHYL BROMIDE CEPHALOTAXINE HOMATROPINE HYDROCHLORIDE 2,2,5,5-Tetramethyl-α-[(2-methylphenoxy)methyl]-1-pyrrolidineethanol

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