1-Methyl-2-pyrrolidineethanol
- Product Name
- 1-Methyl-2-pyrrolidineethanol
- CAS No.
- 67004-64-2
- Chemical Name
- 1-Methyl-2-pyrrolidineethanol
- Synonyms
- Clemastine Impurity 4;Clemastine Impurity D;Clemastine EP Impurity D;1-METHYL-2-PYRROLIDINEETHANOL;N-METHYL-2-PYRROLIDINEETHANOL;HYDROXYETHYLMETHYLPYRROLIDINE;1-Methylpyrrolidine-2-Ethanol;N-Methyl-2-ethanol-pyrrolidine;2-(2-Hydroxyethyl)-N-Methyl-Py;2-PYRROLIDINEETHANOL, 1-METHYL-
- CBNumber
- CB4441351
- Molecular Formula
- C7H15NO
- Formula Weight
- 129.2
- MOL File
- 67004-64-2.mol
1-Methyl-2-pyrrolidineethanol Property
- Boiling point:
- 110-112 °C14 mm Hg(lit.)
- Density
- 0.951 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.4713(lit.)
- Flash point:
- 184 °F
- storage temp.
- 2-8°C(protect from light)
- form
- clear liquid
- pka
- 15.03±0.10(Predicted)
- color
- Colorless to Red to Green
- InChI
- InChI=1S/C7H15NO/c1-8-5-2-3-7(8)4-6-9/h7,9H,2-6H2,1H3
- InChIKey
- FYVMBPXFPFAECB-UHFFFAOYSA-N
- SMILES
- N1(C)CCCC1CCO
- CAS DataBase Reference
- 67004-64-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BP526
- Product name
- 2-(2-Hydroxyethyl)-1-methylpyrrolidine
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $234
- Updated
- 2025/07/31
- Product number
- 139513
- Product name
- 1-Methyl-2-pyrrolidine ethanol
- Purity
- 98%
- Packaging
- 5g
- Price
- $59
- Updated
- 2025/07/31
- Product number
- 139513
- Product name
- 1-Methyl-2-pyrrolidine ethanol
- Purity
- 98%
- Packaging
- 25g
- Price
- $261
- Updated
- 2023/01/07
- Product number
- M0908
- Product name
- 2-(2-Hydroxyethyl)-1-methylpyrrolidine
- Purity
- >98.0%(GC)(T)
- Packaging
- 10mL
- Price
- $86
- Updated
- 2025/07/31
- Product number
- M0908
- Product name
- 2-(2-Hydroxyethyl)-1-methylpyrrolidine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25mL
- Price
- $165
- Updated
- 2025/07/31
1-Methyl-2-pyrrolidineethanol Chemical Properties,Usage,Production
Chemical Properties
clear yellow to brownish liquid
Uses
2-(2-Hydroxyethyl)-1-methylpyrrolidine BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.
Also used in monographs such as:
General Description
1-Methyl-2-pyrrolidine ethanol is an important pharmaceutical intermediate.
Synthesis
51856-76-9
67004-64-2
The general procedure for the synthesis of N-methyl-2-(2-hydroxyethyl)pyrrolidine from methyl 1-methylpyrrolidine-2-acetate was as follows: 5.0 g of intermediate 2 was weighed and placed in a round-bottomed flask, and 50 mL of methanol was added to dissolve it. Subsequently, 2.0 g NaBH4 was slowly added to the reaction system, heated to reflux and kept for 12 hours. After completion of the reaction, methanol was removed by rotary evaporation under reduced pressure. To the residue, 50 mL of ethyl acetate (EA) and 50 mL of water were added, transferred to a dispensing funnel, and the organic layer was separated by sufficiently shaking and standing to separate the layers. The organic layer was washed with saturated saline and dried with anhydrous sodium sulfate. After filtration to remove the desiccant, the organic solvent was concentrated under reduced pressure to obtain 3.5 g of the target product N-methyl-2-(2-hydroxyethyl)pyrrolidine in the form of a colorless liquid.
References
[1] Patent: KR2016/141950, 2016, A. Location in patent: Paragraph 0037
1-Methyl-2-pyrrolidineethanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Methyl-2-pyrrolidineethanol manufacturers
- Product
- 1-Methyl-2-pyrrolidineethanol 67004-64-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 20 tons
- Release date
- 2025-04-11
- Product
- 1-Methyl-2-pyrrolidineethanol 67004-64-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-28
- Product
- 1-Methyl-2-pyrrolidineethanol 67004-64-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98% Min.
- Supply Ability
- 2000KG
- Release date
- 2024-11-03