2-Bromo-2',4'-dichloroacetophenone

Product Name: 2-Bromo-2',4'-dichloroacetophenone
CAS No.: 2631-72-3
Chemical Name: 2-Bromo-2',4'-dichloroacetophenone
Synonyms: 2-bromo-1-(2,4-dichlorophenyl)ethan-1-one;2-BROMO-1-(2,4-DICHLOROPHENYL)ETHANONE;AKOS BBS-00003995;TIMTEC-BB SBB003050;2-Bromo-2’,4’-dichL;Ketoconazole Impurity 37;2,4-DICHLOROPHENACYL BROMIDE;2,4-DichlorophenacylBromide>2,4-Dichlorophenacyl bromide 97%;2-BROMO-2",4"-DICHLOROCETOPHENONE
CBNumber: CB4445713
Molecular Formula: C8H5BrCl2O
Formula Weight: 267.93
MOL File: 2631-72-3.mol

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2-Bromo-2',4'-dichloroacetophenone Property

Melting point:: 25-29 °C(lit.)
Boiling point:: 103-106 °C(Press: 0.4 Torr)
Density: 1.695±0.06 g/cm3(Predicted)
refractive index: 1.60
Flash point:: >230 °F
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform, Methanol
form: Low Melting Solid
color: White to brown
Sensitive: Lachrymatory
InChI: InChI=1S/C8H5BrCl2O/c9-4-8(12)6-2-1-5(10)3-7(6)11/h1-3H,4H2
InChIKey: DASJDMQCPIDJIF-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=C(Cl)C=C1Cl)CBr
CAS DataBase Reference: 2631-72-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,C
Risk Statements: 36/37/38
Safety Statements: 26-36
RIDADR: UN 3335
WGK Germany: 3
Hazard Note: Corrosive/Lachrymatory
HazardClass: 8
PackingGroup: II
HS Code: 29147000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H290May be corrosive to metals

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 595268
Product name: 2-Bromo-2′,4′-dichloroacetophenone
Purity: 97%
Packaging: 1g
Price: $82.2
Updated: 2023/01/07

Sigma-Aldrich

Product number: 595268
Product name: 2-Bromo-2′,4′-dichloroacetophenone
Purity: 97%
Packaging: 5g
Price: $142
Updated: 2023/01/07

TCI Chemical

Product number: D3351
Product name: 2,4-Dichlorophenacyl Bromide
Purity: >98.0%(GC)
Packaging: 5g
Price: $101
Updated: 2025/07/31

TRC

Product number: B683405
Product name: 2-Bromo-2'',4''-dichloroacetophenone
Packaging: 100g
Price: $795
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0017689
Product name: 2',4'-DICHLOROPHENACYL BROMIDE
Purity: 95.00%
Packaging: 25G
Price: $1177.75
Updated: 2021/12/16

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2-Bromo-2',4'-dichloroacetophenone Chemical Properties,Usage,Production

Chemical Properties

White to brown low melting solid

Uses

2-Bromo-2',4'-dichloroacetophenone is a metabolite of the insecticide Bromfenvinphos. It is also a useful intermediate in the preparation of substituted acetophenone derivatives.

Synthesis

2234-16-4

2631-72-3

General procedure for the synthesis of 2-bromo-2',4'-dichloroacetophenone from 2,4-dichloroacetophenone: N-bromosuccinimide (0.37 mmol) was slowly added to a stirred solution of 2,4-dichloroacetophenone (0.37 mol, 1 equiv) in acetonitrile (40 mL). The reaction mixture was continued to be stirred for 10-15 minutes. Subsequently, p-toluenesulfonic acid (p-TsOH, 0.74 mmol, 2 eq.) was added to the reaction system and the mixture was heated to reflux for 4-5 h. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was cooled to room temperature, washed with saturated sodium bicarbonate solution and subsequently extracted with ethyl acetate (3 x 20 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by silica gel column chromatography with the eluent being a solvent mixture of ethyl acetate and hexane (4:96, v/v), and the fractions on 100-200 mesh silica gel were collected to give the pure 2-bromo-2',4'-dichloroacetophenone.

References

[1] Farmaco, 1993, vol. 48, # 6, p. 857 - 869
[2] Journal of Medicinal Chemistry, 2018, vol. 61, # 13, p. 5679 - 5691
[3] Polish Journal of Chemistry, 1981, vol. 55, # 2, p. 399 - 409
[4] Medicinal Chemistry Research, 2016, vol. 25, # 10, p. 2335 - 2348
[5] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 1665 - 1674

2-Bromo-2',4'-dichloroacetophenone Preparation Products And Raw materials

Raw materials

Chloroform Aluminum chloride 1,3-Dichlorobenzene

Preparation Products

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2-Bromo-2',4'-dichloroacetophenone Suppliers

Americas 1 Austria 1 Belgium 3 Canada 2 China 159 Europe 3 Germany 5 India 9 Japan 2 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 2 United Kingdom 14 United States 44 Global 249

Sichuan Hainuowei Technology Co. Ltd.

Tel: 13708085536 13708085536
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Nanjing XiLang Chemical Products Co., Ltd.

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BTC Pharmaceutical CO. Ltd

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J & K SCIENTIFIC LTD.

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Liaoning Tianhua Chemical Co., Ltd.

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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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ProdList: 24529
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Ark Pharm, Inc.

Tel: 847-367-3680
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Energy Chemical

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Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
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View Lastest Price from 2-Bromo-2',4'-dichloroacetophenone manufacturers

Shanghai Xinchem Co., Ltd.

Product: 2-Bromo-2',4'-dichloroacetophenone 2631-72-3
Price: US $0.00-0.00/drums
Min. Order: 1drums
Purity: 99%min.
Supply Ability: 10tons
Release date: 2023-10-22

Career Henan Chemical Co

Product: 2-Bromo-2',4'-dichloroacetophenone 2631-72-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10000KGS
Release date: 2019-12-26

2631-72-3, 2-Bromo-2',4'-dichloroacetophenoneRelated Search:

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2-Bromo-1-(2,4-dichlorophenyl)ethan-1-one, 2-Bromo-2',4'-dichloroacetophenone

2,4-Dichlorophenyl BroMoMethyl Ketone

AKOS BBS-00003995

2-BROMO-1-(2,4-DICHLOROPHENYL)ETHANONE

2,4-DICHLOROPHENACYL BROMIDE

TIMTEC-BB SBB003050

2,4-DichlorophenacylBromide&gt

2-Bromo-2’,4’-dichL

Ethanone, 2-bromo-1-(2,4-dichlorophenyl)-

2-bromo-2',4'-dichloroacetophenone

Ketoconazole Impurity 37

2-Bromo-2′,4′-dichloroacetophenone, CAS 2631-72-3

2,4-Dichlorophenacyl Bromide 98%min

2-Bromo-2',4'-dichloroacetophenone

2631-72-3

170894-54-8

C8H5OBrCl2

Cl2C6H3COCH2Br

Ketones

Building Blocks

C7 to C8

Carbonyl Compounds

Organic Building Blocks

Building Blocks

C7 to C8

Carbonyl Compounds

Chemical Synthesis

Organic Building Blocks

Acetophenone series

C7 to C8

Carbonyl Compounds

Ketones