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PODOPHYLLUM RESIN

Product Name
PODOPHYLLUM RESIN
CAS No.
9000-55-9
Chemical Name
PODOPHYLLUM RESIN
Synonyms
PODOPHYLLIN;podophyllum;Podophylline;podofillina;Podophyll resin;Podophyllum Resi;PODOPHYLLUM RESIN;PODOPHYLIUM RESIN;Resins Podophyllum;PODOCARPIC ACID(RG)
CBNumber
CB4451718
Molecular Formula
C88H92O34
Formula Weight
1693.65168
MOL File
9000-55-9.mol
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PODOPHYLLUM RESIN Property

storage temp. 
2-8°C
form 
powder
color 
brown
Stability:
Stable. Incompatible with strong oxidizing agents.
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Safety

Hazard Codes 
T+
Risk Statements 
61-26/27/28-34
Safety Statements 
53-26-27-36/37/39-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
TP8925000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H360May damage fertility or the unborn child

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
P681055
Product name
Podophyllin
Packaging
10g
Price
$120
Updated
2021/12/16
Usbiological
Product number
287345
Product name
Podophyllum resin
Packaging
2g
Price
$286
Updated
2021/12/16
Biosynth Carbosynth
Product number
FP32716
Product name
Podophyllum resin
Packaging
25g
Price
$325
Updated
2021/12/16
Biosynth Carbosynth
Product number
FP32716
Product name
Podophyllum resin
Packaging
50g
Price
$500
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0031887
Product name
PODOPHYLLUM RESIN
Purity
95.00%
Packaging
5MG
Price
$503.8
Updated
2021/12/16
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PODOPHYLLUM RESIN Chemical Properties,Usage,Production

Chemical Properties

light yellow to brown powder

Uses

Common and plantar warts. Skin carcinomas, in various cancer treatments

Uses

Podophyllin is a resin extracted from the root of the plant Podophyllum sp. Berberidaceae (mandrake), which contains numerous compounds, among which podophyllotoxin.

Uses

antiallergic

Definition

Extractives and their physically modified derivatives. It is a product which may contain resin acids and their esters, terpenes, and oxidation or polymerization products of these terpenes. (Podophyllum pelalatum, Berberidaceae).

Indications

Podophyllin in a 10% to 25% suspension in a tincture of benzoin or alcohol can be used with success. Since this compound contains two mutagens, quercetin and kaempherol, it should used with caution in the physician’s office. It should stay on for 1 to 4 hours and be applied every week for 4 to 6 weeks. Podofilox (0.05 mL of 5%) is safer than podophyllin and should be self-applied twice a day for 3 days followed by 4 rest days to complete a treatment cycle. Topical 0.5% podophyllotoxin cream has been used b.i.d. for 3 consecutive days for a maximum of 4 weeks with clearance in 54% of patients. Podophyllum resin (podophyllin), or podofilox, a cytotoxic agent that arrests mitosis in metaphase, is used primarily for treatment of condyloma acuminata but may also be used on all other types of warts. Although now rarely available, a 25% preparation of podophyllum in compound tincture of benzoin should be applied overnight when treating common nongenital warts. A more commonly available preparation, podofilox 0.5% gel (Condylox), should be applied twice a day for 3 days, then discontinued for 4 consecutive days. The same cycle is continued until eradication of the lesions. The effectiveness as well as the irritant potential of this medication may be increased by covering with adhesive tape or plastic tape (Blenderm).

brand name

Biliboldo;Bon korets;Condilomin;Condyline;Dermacytostat;Podofilm;Salicylin-p;Vericap;Wartec;Warticon;Wartkil;Wart-off.

World Health Organization (WHO)

Podophyllum resin, which is extracted from Indian podophyllum, is highly irritant to the skin and mucous membranes and its use in purgatives is now obsolescent. However, topical preparations remain available for the treatment of venereal and other warts and the drug is included in the WHO Model List of Essential Drugs for this purpose. Podophyllin extracts have been demonstrated to have a teratogenic potential which has led to their withdrawal in some countries and restriction of use in others. They are best avoided during pregnancy. (Reference: (WHTAC1) The Use of Essential Drugs, 2nd Report of the WHO Expert Committee, 722, , 1985)

General Description

Podophyllin is an alcoholic plant extract, obtained from the dried rhizome and roots of?Podoplryllui emodi. It is a powder with colors varying from light brown to greenish-yellow and exposure to heat or light turns it darker.

Biochem/physiol Actions

Podophyllin is used to treat condylomata acuminate, a type of venereal warts. It exhibit several biological functions and is mainly used in the treatment of constipation, hepatic disorder and rheumatic arthritis.

Mechanism of action

Podophyllum resin (podophyllin) is a chemically complex extract obtained from the roots of either of the two plants: Podophyllum peltatum (American) or Podophyllum emodi (Indian) (also called Mandrake or May-apple). Podofilox is the most cytotoxic ingredient in podophyllum resin (present in concentrations of 15% to 20% in P. peltatum and 30% to 40% in P. emodi resins) and exerts its effect by binding to intracellular microtubular proteins and thereby preventing the development of the mitotic spindle. In vitro, podophyllum also inhibits RNA synthesis. Podophyllum is used in the treatment of condyloma acuminata and other warts.

Side effects

Podophyllin can cause severe irritation and, if absorbed in large quantities, may produce systemic toxic effects. It is inadvisable to apply it in large amounts to mucous membranes, and it is unwise to use it in pregnant women because of its possible cytotoxic action on the fetus.

Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. An irritant to skin, eyes, and mucous membranes. Questionable carcinogen with experimental neoplastigenic data. An experimental teratogen. Other experimental reproductive effects. Combustible when exposed to heat or flames. When heated to decomposition it emits acrid smoke and irritating fumes.

PODOPHYLLUM RESIN Preparation Products And Raw materials

Raw materials

Preparation Products

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PODOPHYLLUM RESIN Suppliers

Shaanxi xintianyu Biotechnology Co., Ltd.
Tel
17749282610
Fax
029-32562222
Email
3002817800@qq.com
Country
China
ProdList
981
Advantage
58
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Shaanxi Pioneer Biotech Co., Ltd.
Tel
13720616393;029-84385017-8003 13720616393
Fax
029-84385017
Email
sales@pioneerbiotech.com
Country
China
ProdList
1063
Advantage
56
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11481
Advantage
59
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
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View Lastest Price from PODOPHYLLUM RESIN manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
PODOPHYLLUM RESIN 9000-55-9
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2021-09-14
Henan Fengda Chemical Co., Ltd
Product
PODOPHYLLUM RESIN 9000-55-9
Price
US $50.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-22
Hebei Mojin Biotechnology Co., Ltd
Product
PODOPHYLLUM RESIN 9000-55-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-25

9000-55-9, PODOPHYLLUM RESINRelated Search:


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