4'-Methylthioacetophenone

Product Name: 4'-Methylthioacetophenone
CAS No.: 1778-09-2
Chemical Name: 4'-Methylthioacetophenone
Synonyms: Ethanone, 1-[4-(methylthio)phenyl]-;4-(METHYLTHIO)ACETOPHENONE;4-(Methyl thio);p-Acetylthioanisole;4'-Methylthioacetoph;Glycerol Impurity 24;4-(ACETYL)THIOANISOLE;Etoricoxib Impurity 61;4-THIOMETHYLACETOPHENONE;4'-Methylthioacetophenone
CBNumber: CB4454274
Molecular Formula: C9H10OS
Formula Weight: 166.24
MOL File: 1778-09-2.mol

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4'-Methylthioacetophenone Property

Melting point:: 80-82 °C(lit.)
Boiling point:: 135 °C
Density: 1.1369 (rough estimate)
refractive index: 1.5600 (estimate)
Flash point:: 135°C/1mm
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform, Methanol
form: Solid
color: White to Off-White
BRN: 1860517
InChI: InChI=1S/C9H10OS/c1-7(10)8-3-5-9(11-2)6-4-8/h3-6H,1-2H3
InChIKey: JECUZQLBQKNEMW-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=C(SC)C=C1)C
CAS DataBase Reference: 1778-09-2(CAS DataBase Reference)
NIST Chemistry Reference: 4-CH3S-C6H4-COCH3(1778-09-2)
EPA Substance Registry System: 4'-(Methylmercapto)acetophenone (1778-09-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29309099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 396583
Product name: 4′-(Methylthio)acetophenone
Purity: 97%
Packaging: 1g
Price: $28.9
Updated: 2024/03/01

TCI Chemical

Product number: M1672
Product name: 4'-(Methylthio)acetophenone
Purity: >98.0%(GC)
Packaging: 5g
Price: $71
Updated: 2024/03/01

TCI Chemical

Product number: M1672
Product name: 4'-(Methylthio)acetophenone
Purity: >98.0%(GC)
Packaging: 25g
Price: $207
Updated: 2024/03/01

Alfa Aesar

Product number: L18074
Product name: 4'-(Methylthio)acetophenone, 99%
Packaging: 5g
Price: $88.65
Updated: 2024/03/01

Alfa Aesar

Product number: L18074
Product name: 4'-(Methylthio)acetophenone, 99%
Packaging: 25g
Price: $323.65
Updated: 2024/03/01

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4'-Methylthioacetophenone Chemical Properties,Usage,Production

Chemical Properties

White to light yellow crystal powde

Uses

4′-(Methylthio)acetophenone may be used for the synthesis of Vioxx (Rofecoxib), an non-steroidal anti-inflammatory drug (NSAID). It may be used in the synthesis of (E)-1-[4-(methylsulfanyl)phenyl]-3-phenylprop-2-en-1-one.

Synthesis Reference(s)

Journal of the American Chemical Society, 73, p. 2857, 1951 DOI: 10.1021/ja01150a127
The Journal of Organic Chemistry, 56, p. 5955, 1991 DOI: 10.1021/jo00020a048

General Description

4′-(Methylthio)acetophenone (4-(Methylthio)acetophenone, p-(methylthio) acetophenone, 4-MTAP) is a sulphur containing organic building block. It is a key intermediate in drug synthesis. Its industrial preparation, via Friedel-Crafts acylation reaction in the presence of aluminium chloride as catalyst and acetyl chloride as acylating agent has been reported. It has been prepared by the acetylation reaction of thioanisole with acetic anhydride in the presence of solid acid catalyst.

4'-Methylthioacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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4'-Methylthioacetophenone Suppliers

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View Lastest Price from 4'-Methylthioacetophenone manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4"-Methylthioacetophenone 1778-09-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 4'-Methylthioacetophenone 1778-09-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2018-08-20

1778-09-2, 4'-MethylthioacetophenoneRelated Search:

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4'-(Methylthio)acetophenone,97%

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1-[4-(METHYLSULFANYL)PHENYL]ETHANONE

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4'-(Methylthio)acetophenone&gt

Etoricoxib Impurity 61

4 ′- (meththyl) phenylacetone

Glycerol Impurity 24

4'-Methylthioacetophenone

1778-09-2

C9H10OS

CH3SC6H4COCH3

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