8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Product Name: 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
CAS No.: 31251-41-9
Chemical Name: 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
Synonyms: 8-Chloro-10;Keto loratadine;Loratad Impurity B;2-b]pyridin-11-one;D] cycloheptan-5-one;Loratadine impurity B;6-dihydro-11H-benzo[5;Loratadine tricycline;Loratadine EP IMpurity B;Loratadine Impurity B（EP ）
CBNumber: CB4456713
Molecular Formula: C14H10ClNO
Formula Weight: 243.69
MOL File: 31251-41-9.mol

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8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Property

Melting point:: 90-92°C
Boiling point:: 433.6±45.0 °C(Predicted)
Density: 1.313±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 3.14±0.20(Predicted)
color: Pale Yellow to Pale Brown
InChI: InChI=1S/C14H10ClNO/c15-11-5-6-12-10(8-11)4-3-9-2-1-7-16-13(9)14(12)17/h1-2,5-8H,3-4H2
InChIKey: WMQNOYVVLMIZDV-UHFFFAOYSA-N
SMILES: C12C(=O)C3=CC=C(Cl)C=C3CCC1=CC=CN=2
CAS DataBase Reference: 31251-41-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HS Code: 2933997500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2309
Product name: Loratadine Related Compound C
Purity: Pharmaceutical Secondary Standard; Certified Reference Standard
Packaging: 50MG
Price: $621.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1370269
Product name: Loratadine Related Compound C
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 15mg
Price: $1250
Updated: 2025/07/31

TCI Chemical

Product number: C3181
Product name: 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $155
Updated: 2025/07/31

TCI Chemical

Product number: C3181
Product name: 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $387
Updated: 2025/07/31

TRC

Product number: C365245
Product name: 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
Packaging: 500mg
Price: $135
Updated: 2021/12/16

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8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (Loratadine EP Impurity B; Loratadine USP Related Compound C) is a Loratadine intermediate. Loratidine impurity C.

Synthesis

31255-57-9

31251-41-9

General procedure for the synthesis of 8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one from 3-(3-chlorophenylethyl)pyridine-2-carbonitrile: 8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (10 g) obtained in step C was dissolved in trifluorosulfonic acid (80 ml) and the reaction was stirred at 60 °C for 1 hour. Subsequently, aqueous 6N hydrochloric acid (80 ml) was added slowly and dropwise at room temperature. The reaction mixture was refluxed for 1 hour and poured into ice water. The reaction solution was neutralized with 50% aqueous sodium hydroxide, the precipitate precipitated was separated, washed with water and recrystallized by solvent mixture of isopropanol/water (3:1) to afford the target product 8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one. The mother liquor was concentrated and the residue was washed sequentially with water and chloroform to afford additionally 8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (9.4 g, yield 94%).1H NMR (MeOD-d4) δ: 3.3-3.4 (m, 2H), 3.4-3.5 (m, 2H), 7.5 (m, 2H), 8.1-8.2 (m, 2H), 8.7 (d, 1H), 8.9 (d, 1H).

References

[1] Patent: WO2006/116157, 2006, A2. Location in patent: Page/Page column 56-57
[2] Journal of Medicinal Chemistry, 2009, vol. 52, # 6, p. 1778 - 1782
[3] Journal of Medicinal Chemistry, 1991, vol. 34, # 1, p. 457 - 461

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one 31251-41-9
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KGS
Release date: 2021-06-05

Career Henan Chemical Co

Product: 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one 31251-41-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-12-25

31251-41-9, 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-oneRelated Search:

Pyridine hydrobromide Copper Pyrithione 2-Chloro-3-cyanopyridine Zinc pyrithione Benzo[b]thien-2-ylboronic acid Clopidol Pentachloropyridine Pyridine hydrofluoride 3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 4,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-β]pyridin-11-one (Loratadine Impurity) Loratadine Impurity 17 3-Hydroxy loratadine Loratadine Impurity 13 Loratadine Impurity 13 8-Chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol Loratadine Impurity 15 Loratadine EP IMpurity F

8-CHLORO-5,6-DIHYDRO-11H-BENZO-(5,6)-CYCLOHEPTA-(1,2-B)-PYRIMIDINE-11-ON

8-Chloro-10,11-dihydro-4-aza-5

8-chloro-10,11-dihydro-4-AZA-5H-benzo〔A,D〕cyclohepta-5-one

8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIMIDINE-11-ONE

4-Aza-8-chloro-10,11-dihydro-5H-benzo[a,d]cyclo-5-heptanone

8-CHLORO-10,11-DIHYDRO-4 AZA-5H-BENZO[A,D] CYCLOHEPTAN-5-ONE =98%

8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-ONE

8-CHLORO-10,11-DIHYDRO-4-AZA-5H-DIBENZO-(A,D)CYCLOHEPTAN-5-ONE

8-CHLORO-10,11-DIHYDRO-4-AZA-5H-BENZO[A,D] CYCLOHEPTAN-5-ONE

8-CHLORO-6,11-DIHYDRO-11-(1-METHYL-4-PIPERIDYLEDENE)-5H-BENZO(5,6)-CYCLOHEPTA(1,2,B)PYRIDINE

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-β]pyridin-11-one

11-dihydro-4-aza-5H-benzo[A

8-Chloro-10

D] cycloheptan-5-one

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclo hepta[1,2-b]pyridin-11-

Loratadine Related Compound C (15 mg) (8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one)

Loratadine EP IMpurity B

Loratadine Related CoMpound C

11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one,8-chloro-5,6-dihydro-

Loratadine impurity B

8-Chloro-5,6-dihydro-11<i>H</i>-benzo[5,6]cyclohepta[1,2-<i>b</i>]pyridin-11-one

Keto loratadine

Loratadine Impurity 2(Loratadine EP Impurity B)

Loratad Impurity B

8-Chloro-5,6-dihydro-11H-benzo[5.6]

4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclo-

2-b]pyridin-11-one

6-dihydro-11H-benzo[5

8-Chloro-10,11-dihydro-4-AZA-5H-dibenzo(a,d)- Cyclohepten-5-One(or)(Loraketone)

13-chloro-4-azatricyclo[9.4.0.0,3,8]pentadeca-1(15),3,5,7,11,13-hexaen-2-one

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (Desloratadine Impurity)

Loratidine EP Impurity B/ Loratidine Related Compound C

8-Chloro-10,11-dihydro-4-aza-5H-dibenzo[a,d]cycloheptan-5-on...

Loratadine Related Compound C (8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one) (1370269)

Loratadine Impurity B（EP ）

Loratadine USP Related Compound C

8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

8-Chloro-10,11-dihydro-4-aza-5H-dibenzo (a,d)ycloheptan-5-one

2-chloromethyl-3-methy1-4-(2,2,2- triflu oroethoxy) pyridine hydrochloride

Loratadine tricycline

8-chloro-5,6-dihydro-11H-benzo [5,6] cycloheptano [1,2-b] pyridin-11 one

8-chloro-10,Chemicalbook11-dihydro-4-AZA-5H-benzo〔A,D〕cyclohepta-5-one

13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-one

Loratadine EP Impurity B (Loratadine USP Related Compound C)

31251-41-9

31521-41-9

C14H10ClNO

Aromatics

Heterocycles

Intermediates

Aromatics Compounds