Description References
ChemicalBook > CAS DataBase List > Riboflavin 5'-Monophosphate Sodium Salt

Riboflavin 5'-Monophosphate Sodium Salt

Description References
Product Name
Riboflavin 5'-Monophosphate Sodium Salt
CAS No.
130-40-5
Chemical Name
Riboflavin 5'-Monophosphate Sodium Salt
Synonyms
RIBOFLAVIN SODIUM PHOSPHATE;FLAVIN MONONUCLEOTIDE;RIBOFLAVIN-5-PHOSPHATE;Ribo;RIBOFLAVIN 5'-PHOSPHATE SODIUM;Tenofovir Impurity 155;SODIUM RIBOFLAVIN PHOSPHATE;Vitamin B2 Sodium Phosphate;RIBOFLAVINE SODIUM PHOSPHATE;Riboflavin Phosphate Sodium Salt
CBNumber
CB4472478
Molecular Formula
C17H22N4NaO9P
Formula Weight
480.35
MOL File
130-40-5.mol
More
Less

Riboflavin 5'-Monophosphate Sodium Salt Property

Melting point:
>300°C
alpha 
[α]D20 +38～+43° (c=1.5, dil. HCl) (Calculated on dehydrous basis)
FEMA 
2976 | QUININE HYDROCHLORIDE
refractive index 
41 ° (C=1.5, 5mol/L HCl)
storage temp. 
2-8°C
solubility 
H2O: soluble50mg/mL, clear, orange
form 
powder
color 
Yellow to Dark Orange
optical activity
[α]20/D +37 to +42°, c = 1.5 in 5 M HCl(lit.)
Water Solubility 
almost transparency
Merck 
14,8201
BRN 
4106529
Stability:
Stable. Incompatible with strong oxidizing agents, reducing agents, bases, calcium, metallic salts. Protect from light, air and moisture.
LogP
-2.193 (est)
CAS DataBase Reference
130-40-5(CAS DataBase Reference)
EPA Substance Registry System
Riboflavin 5'-(dihydrogen phosphate), monosodium salt (130-40-5)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/38
Safety Statements 
22-24/25-37/39-26
WGK Germany 
3
F 
3-8-10
HS Code 
29362300
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F1392
Product name
Riboflavin 5′-monophosphate sodium salt hydrate
Purity
≥70%
Packaging
25mg
Price
$95.2
Updated
2024/03/01
Sigma-Aldrich
Product number
77623
Product name
Riboflavin 5′-monophosphate sodium salt
Purity
tested according to Ph. Eur.
Packaging
50g
Price
$284
Updated
2024/03/01
Sigma-Aldrich
Product number
R0630000
Product name
Riboflavin sodium phosphate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
R0630000
Price
$151
Updated
2023/06/20
TCI Chemical
Product number
R0023
Product name
Riboflavin 5'-Monophosphate Sodium Salt
Purity
>93.0%(E)
Packaging
5g
Price
$31
Updated
2021/12/16
TCI Chemical
Product number
R0023
Product name
Riboflavin 5'-Monophosphate Sodium Salt
Purity
>93.0%(E)
Packaging
25g
Price
$91
Updated
2021/12/16
More
Less

Riboflavin 5'-Monophosphate Sodium Salt Chemical Properties,Usage,Production

Description

Riboflavin-5-phosphate sodium (sodium FMN,130-40-5) consist mainly monosodium salt of Riboflavin 5-phophate (FMN), the 5-monophosphate ester of riboflavin. Riboflavin-5-phosphate sodium is produced by direct reaction of riboflavin with a phosphorylating agent such as phosphorous oxychloride in an organic solvent.
Riboflavin 5-phophate (FMN) is essential as a coenzyme in various enzymic reactions in the body and is therefore used in the form of its salts, especially in the form of sodium FMN, as additive to drugs and human and animal food. Sodium FMN is also used as starting material for flavin adenine dinucleotide which is employed for treating vitamin B2 deficiency. It is used as a yellow food color additive (E106).  Riboflavin 5-phosphate sodium is fairly stable in air but is hygroscopic and sensitive to heat and light. The product may be stored for 33 months from the date of manufacture in the unopened original container and at a temperature below 15 °C.

References

[1] https://en.wikipedia.org/wiki/Flavin_mononucleotide
[2] Scientific Opinion on the re-evaluation of riboflavin (E101(i)) and riboflavin-5’-phosphate sodium (E 101(ii)) as food additives, EFSA Journal 2013
[3] Patent US 5095115A: Preparation of riboflavin 5'-phosphate (fmn) and its sodium salt in a lactone

Chemical Properties

Riboflavin 5'-Monophosphate Sodium Salt is a yellow toorange-yellow, crystalline hygroscopic powder. It is odorless, and has a slightly bitter taste.

It is soluble in water, and practically insoluble in ethanol(95), in chloroform and in diethyl ether.
It is decomposed on exposure to light.

Uses

One of the bioactive forms of Riboflavin. Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor).

Uses

Riboflavin 5′-monophosphate sodium salt hydrate has been used:

  • as a component of assay buffer to determine the luminescence of L. lactis cells
  • as a component of the reaction mixture in nitric oxide synthase (NOS) enzymatic activity assay
  • in the high performance liquid chromatography (HPLC) analysis of Flavin mononucleotide (FMN) cyclase products
  • in luciferase assay with firefly luciferase

Uses

antibacterial.
Riboflavin 5′-monophosphate sodium salt was used as water-soluble model drug in a combined conventional inkjet printing technology with flexographic printing for the fabrication of drug delivery systems.It may be employed as initiator for the photo-initiated polymerization of acrylamide.It may be employed in chronoamperometric assay for vanadium ions.
Riboflavin 5′-monophosphate is also known as flavin mononucleotide (FMN). FMN is a water-soluble micronutrient. It is enzymatically produced from riboflavin (RF).Riboflavin 5′-monophosphate is one of the constituent of enzyme cofactor flavin-adenine dinucleotide.

Definition

ChEBI: Riboflavin sodium phosphate is a ribitol phosphate and a vitamin B2. It is functionally related to a riboflavin.

Application

Riboflavin 5'-Monophosphate Sodium Salt is a coenzyme that is tightly bound to enzymes catalyzing substrate oxidations and reductions, enable an enormous range of chemical transformations in biosynthetic pathways. Riboflavin 5'-Monophosphate Sodium Salt can be used as:
(1) A stable isotope internal standard for the interpretation of data in specific biological samples.
(2) An effective NAD+ reducing agent.
(3) To study progressive keratitis, corneal ectasia and irregular astigmatism.

Biological Functions

Riboflavin 5'-Phosphate Sodium is the phosphate sodium salt form of riboflavin, a water-soluble and essential micronutrient that is the principal growth-promoting factor in naturally occurring vitamin B complexes. Riboflavin phosphate sodium is converted to 2 coenzymes, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are necessary for energy production by aiding in the metabolism of fats, carbohydrates and proteins and are required for red blood cell formation and respiration, antibody production and for regulating human growth and reproduction. Riboflavin phosphate sodium is essential for healthy skin, nails and hair growth.

General Description

Riboflavin 5′-monophosphate is also known as flavin mononucleotide (FMN). FMN is a water-soluble micronutrient. It is enzymatically produced from riboflavin (RF). Riboflavin 5′-monophosphate is one of the constituent of enzyme cofactor flavin-adenine dinucleotide.

Biochem/physiol Actions

Riboflavin 5′-monophosphate or flavin mononucleotide (FMN) possesses fluorescence, photosensitivity and redox activities.

IC 50

Cryptosporidium hominis TS-DHFR: IC50 = 55 μM; Dihydrofolate reductase: IC50 = 325 μM (human); Thymidylate synthase: IC50 >500 μM (human); Dihydrofolate reductase: IC50 >500 μM (Toxoplasma gondii)

Purification Methods

Purify FMN by paper chromatography using tert-butanol/water, cutting out the main spot and eluting it with water. It can also be purified by adsorption onto an apo-flavodoxin column, followed by elution and freeze drying. It crystallises from aqueous acidic solution. [Mayhew & Strating Eur J Biochem 59 539 1976, Beilstein 26 III/IV 2555.]

Riboflavin 5'-Monophosphate Sodium Salt Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Riboflavin 5'-Monophosphate Sodium Salt Suppliers

Australia 1 Austria 1 Belgium 4 Brazil 1 Canada 4 China 382 Czech Republic 1 Egypt 1 Europe 3 France 1 Germany 10 India 68 Ireland 1 Italy 1 Japan 5 Kenya 1 Mexico 1 Philippines 1 Poland 1 Singapore 1 Slovakia 1 South Korea 1 Spain 2 Switzerland 5 The Netherlands 1 Turkey 1 United Arab Emirates 1 United Kingdom 17 United States 67 Global 585
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
ALB Technology Limited
Tel
702-983-3769
Fax
702-983-3769
Email
sales@albtechnology.com
Country
United States
ProdList
2993
Advantage
55
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
Alfa Chemistry
Tel
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
24072
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81215950 4000-868-328
Email
customer@uwalab.com
Country
United States
ProdList
10404
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Alfa Chemistry
Tel
Email
info@alfa-chemistry.com
Country
United States
ProdList
2344
Advantage
58
Creative Enzymes
Tel
1-516-855-7709
Fax
1-631-938-8127
Email
info@creative-enzymes.com
Country
United States
ProdList
8748
Advantage
58
Bosgen Chemical Inc.
Tel
--
Fax
--
Email
sale@chemapi.com
Country
United States
ProdList
609
Advantage
30
Sarchem Laboratories, Inc.
Tel
--
Fax
--
Email
info@sarchemlabs.com
Country
United States
ProdList
736
Advantage
58
Scandinavian Formulas
Tel
--
Fax
--
Email
mikep@scandinavianformulas.com
Country
United States
ProdList
1550
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
Advanced Compounds International. (ACI)
Tel
--
Fax
--
Email
info@advancedcompounds.com
Country
United States
ProdList
74
Advantage
58
Penta Manufacturing Company (a division of Penta International Corporation)
Tel
--
Fax
--
Email
@pentamfg.com
Country
United States
ProdList
901
Advantage
58
Alkano Chemicals, Inc
Tel
--
Fax
--
Country
United States
ProdList
53
Advantage
58
2A Biotech USA
Tel
--
Fax
--
Email
info@2abiotech.com
Country
United States
ProdList
1785
Advantage
58
Advanced Compounds International Inc.,
Tel
--
Fax
--
Country
United States
ProdList
16
Advantage
58
VWR International, LLC.
Tel
--
Fax
--
Email
@sargentwelch.com
Country
United States
ProdList
6262
Advantage
58
Crescent Chemical Company
Tel
--
Fax
--
Email
fran@creschem.com
Country
United States
ProdList
1441
Advantage
58
Prism International Inc.
Tel
--
Fax
--
Country
United States
ProdList
17
Advantage
58
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
TCI America, Inc. (part of Tokyo Chemical Industry)
Tel
--
Fax
--
Email
Angelina.Crew@tcichemicals.com
Country
United States
ProdList
2053
Advantage
58
United Mineral & Chemical Corporation
Tel
--
Fax
--
Country
United States
ProdList
48
Advantage
58
Cameo Healthcare India Pvt. Ltd
Tel
--
Fax
--
Email
sales@cameohealthcare.com
Country
United States
ProdList
29
Advantage
47
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Charkit Chemical Corporation
Tel
--
Fax
--
Email
sales@charkit.com
Country
United States
ProdList
2993
Advantage
65
Creative Enzymes
Tel
--
Fax
--
Email
info@creative-enzymes.com
Country
United States
ProdList
6057
Advantage
58
Glentham Life Sciences Ltd
Tel
--
Fax
--
Email
info@glentham.com
Country
United States
ProdList
2026
Advantage
58
American International Chemical, Inc.
Tel
--
Fax
--
Email
info@aicma.com
Country
United States
ProdList
531
Advantage
58
Penta International Corporation
Tel
--
Fax
--
Email
lisaa@pentamfg.com
Country
United States
ProdList
5042
Advantage
58
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
CEDARBURG PHARMACEUTICALS INC
Tel
--
Fax
--
Email
CorporateCommunications@amriglobal.com
Country
United States
ProdList
34
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Sisco Research Laboratories Pvt. Ltd.
Tel
--
Fax
--
Email
srlmarketing@dishnetdsl.net
Country
United States
ProdList
1905
Advantage
64
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
Labseeker Inc
Tel
--
Fax
--
Email
marketing@labseeker.com
Country
United States
ProdList
1495
Advantage
55
Santa Cruz Biotechnology, Inc.
Tel
--
Fax
--
Email
scbt@scbt.com
Country
United States
ProdList
3597
Advantage
60
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
BADRIVISHAL CHEMICALS & PHARMACEUTICALS
Tel
--
Fax
--
Email
info@badrivishal.com
Country
United States
ProdList
12
Advantage
38
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
More
Less

View Lastest Price from Riboflavin 5'-Monophosphate Sodium Salt manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.
Product
RIBOFLAVIN SODIUM PHOSPHATE 130-40-5
Price
US $0.00-0.00/g
Min. Order
10g
Purity
99% HPLC
Supply Ability
10000
Release date
2024-09-20
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Riboflavin sodium phosphate 130-40-5
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
73.0%~79.0%; USP34
Supply Ability
5000kg/month
Release date
2021-06-03
shandong perfect biotechnology co.ltd
Product
Riboflavin-5-phosphate sodium 130-40-5
Price
US $0.00/g
Min. Order
1g
Purity
98% HPLC
Supply Ability
100kg
Release date
2023-08-09

130-40-5, Riboflavin 5'-Monophosphate Sodium SaltRelated Search:

Trisodium phosphate Riboflavin Clindamycin phosphate Tylosin phosphate Sodium Phosphate Monobasic Monohydrate SULPHOSUCCINIC ACID ESTER Curcumin Emodin Zinc phosphate Calcium phosphate Triethyl phosphate 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT phosphate FLAVIN MONONUCLEOTIDE FLAVIN ADENINE DINUCLEOTIDE Flavin adenine dinucleotide disodium salt RIBOFLAVIN-5'-PHOSPHATE SODIUM SALT DIHYDRATE ALLOXAZINE

  • riboflavin5’-(dihydrogenphosphate),monosodiumsalt
  • flavin mononucleotide sodium*electrophoresis reag
  • riboflavin 5-(sodium hydrogen phosphate)
  • RIBOFLAVIN 5-PHOSPHATE SODIUM USP
  • Riboflavine 5'-monophosphate Sodium salt, Ph Eur
  • FLAVIN MONONUCLEOTIDE SODIUM*ELECTROPHOR ESIS REAGEN
  • Riboflavin-5'-MonophosphateSodium
  • Vitamin B<sub>2</sub> 5'-phosphate monosodium salt
  • RIBOFLAVIN5-PHOSPHATESODIUM,DIHYDRATE,ELECTROPHORESISGRADE
  • RIBOFLAVIN5-PHOSPHATESODIUM,DIHYDRATE,FCC
  • Alloxazine mononucleotide sodium salt
  • Benzo[g]pteridine, riboflavin 5'-(dihydrogen phosphate) deriv.
  • Coflavinase
  • Cytoflav
  • Flamotide
  • Hyryl
  • Ribo
  • Riboflavin 5'-(dihydrogen phosphate), monosodium salt (9CI)
  • Riboflavin 5'-phosphate ester monosodium salt
  • Riboflavin 5′-monophosphate sodium salt
  • SODIUM RIBOFLAVIN PHOSPHATE
  • Riboflavin 5'-phosphate sodiuM, USP grade
  • 7,8-DiMethyl-10-ribitylisoalloxazine Phosphate SodiuM
  • Flavin Mononucleotide Lactoflavin Phosphate Sodium Salt Vitamin B2 Phosphate Sodium Salt
  • RIBOFLAVIN-5'-PHOSPHATE SODIUM SALT(SH)
  • Riboflavin 5'-Monophosphate SodiuM Salt, 73.0 - 79.0% fluoriMetric
  • Riboflavine-5'
  • Riboflavin 5'-monophosphate sodium salt Riboflavini natrii phosphas Flavin Mononucleotide Lactoflavin Phosphate Sodium Salt Vitamin B2 Phosphate Sodium Salt
  • LACTOFLAVINE PHOSPHATE SODIUM SALT
  • LACTOFLAVIN-5'-PHOSPHATE SODIUM SALT
  • FLAVIN MONONUCLEOTIDE
  • FLAVIN MONONUCLEOTIDE SODIUM SALT
  • FMN SODIUM SALT
  • ALLOXAZIN MONONUCLEOTIDE
  • RIBOFLAVINE 5'-MONOPHOSPHATE SODIUM SALT
  • RIBOFLAVINE 5-MONOPHOSPHATE SODIUM SALT
  • Riboflavin-5-phosphoric acid monosodium salt
  • Riboflavine 5'-(dihydrogen phosphate), monosodium salt (6CI, 8CI)
  • Riboflavine monosodium 5'-phosphate
  • Riboflavine, 5'-phosphate, sodium salt (7CI)
  • Sodium FMN
  • SODIUMRIBOFLAVIN5PHOSPHATE
  • RIBOFLAVINACIDSODIUMESTER
  • Riboflavin monophosphate monosodium salt
  • Flavin mononucleotide sodium salt dihydrate, FMN sodium salt dihydrate
  • Riboflavin 5'-phosphate sodium salt dihydrate, USP grade
  • Lactoflavin Phosphate Sodium Salt
  • Riboflavum -5 -dihydrophosphate monosodium salt
  • Riboflavin Phosphate Sodium Salt
  • Ribofavin-5'-phosphate sodium salt dihydrate
  • Riboflavin 5′-monophosphate sodium salt,Riboflavin Sodium phosphate, Riboflavini natrii phosphas
  • RIBOFLAVINE-5-PHOSPHATE DISODIUM SALT extrapure
  • riboflavine 5'-monophosphate sodium salt dihydrate
  • Sodium Riboflaven Phosphate
  • Riboflavin Sodium phosphate, Riboflavini natrii phosphas
  • Riboflavin 5'-(hydrogen phosphoric acid)sodium
  • Riboflavin 5'-phosphoric acid hydrogen sodium salt
  • Riboflavin 5'-phosphoric acid sodium salt