LY-2940094

Product Name: LY-2940094
CAS No.: 1307245-87-9
Chemical Name: LY-2940094
Synonyms: CS-2822;LY-2940094;LY-2940094 tartrate;LY-2940094 tartrate，BTRX-246040;(2-(4-((2'-Chloro-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)methyl)-3-methyl-1H-pyrazol-1-yl)pyridin-3-yl)methanol (2R,3R)-2,3-dihydroxysuccinate
CBNumber: CB44815437
Molecular Formula: C26H29ClF2N4O8S
Formula Weight: 631.04
MOL File: 1307245-87-9.mol

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb573470
Product name: LY2940094
Purity: >98%
Packaging: 100mg
Price: $986
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573470
Product name: LY2940094
Purity: >98%
Packaging: 250mg
Price: $1802
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573470
Product name: LY2940094
Purity: >98%
Packaging: 1g
Price: $3580.2
Updated: 2021/12/16

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LY-2940094 Chemical Properties,Usage,Production

Uses

LY2940094 (BTRX-246040) tartrate is a potent, brain penetrant, selective and orally available N/OFQ peptide (NOP) receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 tartrate reduces Ethanol self-administration and Ethanol seeking in animal models[1].

in vivo

LY2940094 (3, 10, or 30 mg/kg; orally daily for 4 days) dose-dependently reduces homecage ethanol self-administration in Indiana Alcohol-Preferring (P) and Marchigian Sardinian Alcohol-Preferring (msP) rats, without affecting food/water intake or locomotor activity^[1].

Animal Model:	Female Alcohol-Preferring (P) rats (250-320 g); Male Marchigian Sardinian Alcohol-Preferring (msP) rats (400-450 g)^[1]
Dosage:	3, 10, or 30 mg/kg
Administration:	P.o.; daily for 4 days
Result:	Reduced homecage ethanol self-administration.

References

[1] Rorick-Kehn LM, et al. A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res. 2016 May;40(5):945-54. DOI:10.1111/acer.13052

LY-2940094 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY-2940094 Suppliers

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1307245-87-9, LY-2940094Related Search:

LY 294002 Hydrochloride 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE LY-404039 LY3143921 LY 2606368 LY 379268 LY2109761

LY-2940094

CS-2822

LY-2940094 tartrate

LY-2940094 tartrate，BTRX-246040

(2-(4-((2'-Chloro-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)methyl)-3-methyl-1H-pyrazol-1-yl)pyridin-3-yl)methanol (2R,3R)-2,3-dihydroxysuccinate

1307245-87-9

C26H29ClF2N4O8S