LY-2940094
- Product Name
- LY-2940094
- CAS No.
- 1307245-87-9
- Chemical Name
- LY-2940094
- Synonyms
- CS-2822;LY-2940094;LY-2940094 tartrate;LY-2940094 tartrate，BTRX-246040;(2-(4-((2'-Chloro-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)methyl)-3-methyl-1H-pyrazol-1-yl)pyridin-3-yl)methanol (2R,3R)-2,3-dihydroxysuccinate
- CBNumber
- CB44815437
- Molecular Formula
- C26H29ClF2N4O8S
- Formula Weight
- 631.04
- MOL File
- 1307245-87-9.mol
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- orb573470
- Product name
- LY2940094
- Purity
- >98%
- Packaging
- 100mg
- Price
- $986
- Updated
- 2021/12/16
- Product number
- orb573470
- Product name
- LY2940094
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1802
- Updated
- 2021/12/16
- Product number
- orb573470
- Product name
- LY2940094
- Purity
- >98%
- Packaging
- 1g
- Price
- $3580.2
- Updated
- 2021/12/16
LY-2940094 Chemical Properties,Usage,Production
Uses
LY2940094 (BTRX-246040) tartrate is a potent, brain penetrant, selective and orally available N/OFQ peptide (NOP) receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 tartrate reduces Ethanol self-administration and Ethanol seeking in animal models[1].
in vivo
LY2940094 (3, 10, or 30 mg/kg; orally daily for 4 days) dose-dependently reduces homecage ethanol self-administration in Indiana Alcohol-Preferring (P) and Marchigian Sardinian Alcohol-Preferring (msP) rats, without affecting food/water intake or locomotor activity[1].
| Animal Model: | Female Alcohol-Preferring (P) rats (250-320 g); Male Marchigian Sardinian Alcohol-Preferring (msP) rats (400-450 g)[1] |
| Dosage: | 3, 10, or 30 mg/kg |
| Administration: | P.o.; daily for 4 days |
| Result: | Reduced homecage ethanol self-administration. |
References
[1] Rorick-Kehn LM, et al. A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res. 2016 May;40(5):945-54. DOI:10.1111/acer.13052
LY-2940094 Preparation Products And Raw materials
Raw materials
Preparation Products
LY-2940094 Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58