IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE
- Product Name
- IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE
- CAS No.
- 6188-43-8
- Chemical Name
- IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE
- Synonyms
- Minodronic Acid Impurity 30;[1,2-α]PYRIDIN-3-CARBOXALDEHYDE;Imidazo[1,2-a]pyridine-3-carbaldehyde;imidazo[3,2-a]pyridine-3-carbaldehyde;3-imidazo[3,2-a]pyridinecarboxaldehyde;IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE;IMIDAZO[1,2-A]PYRIDINE-3-CARBOXALDEHYDE;Imidazo[1,2-a]pyridine-3-carbaldehyde AldrichCPR;Imidazo[1,2-a]pyridine-3-carboxaldehyde (7CI, 8CI, 9CI, ACI)
- CBNumber
- CB4483670
- Molecular Formula
- C8H6N2O
- Formula Weight
- 146.15
- MOL File
- 6188-43-8.mol
IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE Property
- Melting point:
- 127-129 °C
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 4.15±0.50(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- I387593
- Product name
- Imidazo[1,2-a]pyridine-3-carbaldehyde
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- OR909920
- Product name
- Imidazo[1,2-a]pyridine-3-carbaldehyde
- Purity
- 98%
- Packaging
- 1g
- Price
- $115
- Updated
- 2021/12/16
- Product number
- X6765
- Product name
- Imidazo[1,2-a]pyridine-3-carbaldehyde
- Packaging
- 1g
- Price
- $143
- Updated
- 2021/12/16
- Product number
- 040365
- Product name
- Imidazo[1,2-a]pyridine-3-carbaldehyde
- Packaging
- 500mg
- Price
- $252
- Updated
- 2021/12/16
- Product number
- OR909920
- Product name
- Imidazo[1,2-a]pyridine-3-carbaldehyde
- Purity
- 98%
- Packaging
- 5g
- Price
- $330
- Updated
- 2021/12/16
IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE Chemical Properties,Usage,Production
Synthesis
274-76-0
68-12-2
6188-43-8
Freshly distilled phosphorus trichloride (61 mL, 0.65 mol) was slowly added to N,N-dimethylformamide (120 mL, 1.55 mol) at 2 °C. After controlling the reaction temperature to gradually increase to room temperature, the reaction system was again cooled to 2 °C. Subsequently, a solution of N,N-dimethylformamide (60 mL) of imidazo[1,2-a]pyridine (10 g, 0.085 mol) was added dropwise. The reaction mixture was slowly warmed to 105 °C, followed by further warming to 140 °C. The reaction temperature was stabilized at 120 °C by removing the oil bath. Heating was continued at this temperature for 45 minutes, after which the temperature was reduced to 85 °C and continued for 2.5 hours. Upon completion of the reaction, the mixture was cooled and poured into ice-cooled 5% hydrochloric acid (600 mL) and the pH was adjusted with 20% sodium hydroxide solution to 9. The resulting solution was extracted with dichloromethane (1200 mL) overnight. The organic layer was separated, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was washed with water (5 x 15 mL) and dried again to give 3.49 g of imidazo[1,2-a]pyridine-3-carbaldehyde in 31% yield.
References
[1] Farmaco, Edizione Scientifica, 1981, vol. 36, # 12, p. 994 - 1003
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 9, p. 3454 - 3464
[3] European Journal of Medicinal Chemistry, 2011, vol. 46, # 10, p. 4820 - 4826
[4] Journal of Medicinal Chemistry, 1996, vol. 39, # 14, p. 2856 - 2859
[5] Patent: WO2005/66132, 2005, A1. Location in patent: Page/Page column 89-90
IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE manufacturers
- Product
- Imidazo[1,2-a]pyridine-3-carbaldehyde 6188-43-8
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE 6188-43-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-09