ChemicalBook > CAS DataBase List > 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide

2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide

Product Name
2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
CAS No.
1646499-97-9
Chemical Name
2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
Synonyms
ML 382;ML382, 10 mM in DMSO;2-cyclopropanesulfonamido-N-(2-ethoxyphenyl)benzamide;2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide;Benzamide, 2-[(cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)-;ML382,Inhibitor,ML 382,nociceptor,pain,injury,DRG,inhibit,neurons,nervous,ML-382
CBNumber
CB44902689
Molecular Formula
C18H20N2O4S
Formula Weight
360.43
MOL File
1646499-97-9.mol
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2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide Property

Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
A solid
pka
8.30±0.20(Predicted)
color 
White to off-white
InChIKey
RCSLEKLNDJJJLF-UHFFFAOYSA-N
SMILES
O=C(C1=C(C=CC=C1)NS(C2CC2)(=O)=O)NC3=C(C=CC=C3)OCC
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3564
Product name
ML382
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$81.2
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3564
Product name
ML382
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$328
Updated
2025/07/31
Tocris
Product number
5738
Product name
ML382
Purity
≥98%(HPLC)
Packaging
10
Price
$149
Updated
2021/12/16
Tocris
Product number
5738
Product name
ML382
Purity
≥98%(HPLC)
Packaging
50
Price
$622
Updated
2021/12/16
TRC
Product number
M425455
Product name
ML382
Packaging
2.5mg
Price
$165
Updated
2021/12/16
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2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide Chemical Properties,Usage,Production

Uses

ML 382 acts as a potent and selective allosteric modulator of MrgX1, used in the stufy to improve the potency and efficacy of anti-chronic pain medicaments.

Biological Activity

ML382 is a positive allosteric modulator of Mas-related G-protein-coupled receptor X1 (MrgprX1, MrgX1, SNSR4), a G-protein coupled receptor (GPCR) selectively expressed in dorsal root ganglion (DRG) neurons. MrgX1 is believed to be a functional ortholog of mouse MrgC11, which has been shown to be involved in itch and pain. ML382 is selective for MrgX1 over MrgX2, MrgC11 and a panel of 68 other GPCRs, ion channels and transporters, with an EC50 value of 190 nm with an Emax value of 148% in the presence of the known ligand BAM8-22.

in vivo

ML382 (5 μM) significantly increases inhibition of ICa by a low concentration of BAM8–22 (0.5 μM) in DRG neurons from MrgprX1 mice. ML382 enhances the inhibition of spinal synaptic transmission by BAM8-22 in MrgprX1 mice. ML382 (25 μM, 125 μM, and 250 μM; 5 μL; i.th.;) dose-dependently attenuates heat hypersensitivity in MrgprX1 mice. ML382 (lumbar puncture injection; 25 μM, 5 μL) leads to a significant increase in postconditioning time spent in the ML382-paired chamber, compared with the preconditioning value. ML382 inhibits nerve injury-induced ongoing pain in MrgprX1 mice[1].

storage

Store at RT

2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide Suppliers

China 36 United Kingdom 1 United States 6 USA 1 Global 44
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  • 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
  • ML 382
  • Benzamide, 2-[(cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)-
  • ML382,Inhibitor,ML 382,nociceptor,pain,injury,DRG,inhibit,neurons,nervous,ML-382
  • 2-cyclopropanesulfonamido-N-(2-ethoxyphenyl)benzamide
  • ML382, 10 mM in DMSO
  • 1646499-97-9