2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide

Product Name: 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
CAS No.: 1646499-97-9
Chemical Name: 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
Synonyms: ML 382;ML382, 10 mM in DMSO;2-cyclopropanesulfonamido-N-(2-ethoxyphenyl)benzamide;2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide;Benzamide, 2-[(cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)-;ML382,Inhibitor,ML 382,nociceptor,pain,injury,DRG,inhibit,neurons,nervous,ML-382
CBNumber: CB44902689
Molecular Formula: C18H20N2O4S
Formula Weight: 360.43
MOL File: 1646499-97-9.mol

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2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide Property

Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: A solid
pka: 8.30±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 5738
Product name: ML382
Purity: ≥98%(HPLC)
Packaging: 10
Price: $149
Updated: 2021/12/16

Tocris

Product number: 5738
Product name: ML382
Purity: ≥98%(HPLC)
Packaging: 50
Price: $622
Updated: 2021/12/16

TRC

Product number: M425455
Product name: ML382
Packaging: 2.5mg
Price: $165
Updated: 2021/12/16

DC Chemicals

Product number: DC20900
Product name: ML382
Purity: >98%
Packaging: 250mg
Price: $850
Updated: 2021/12/16

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2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide Chemical Properties,Usage,Production

Uses

ML 382 acts as a potent and selective allosteric modulator of MrgX1, used in the stufy to improve the potency and efficacy of anti-chronic pain medicaments.

Biological Activity

ML382 is a positive allosteric modulator of Mas-related G-protein-coupled receptor X1 (MrgprX1, MrgX1, SNSR4), a G-protein coupled receptor (GPCR) selectively expressed in dorsal root ganglion (DRG) neurons. MrgX1 is believed to be a functional ortholog of mouse MrgC11, which has been shown to be involved in itch and pain. ML382 is selective for MrgX1 over MrgX2, MrgC11 and a panel of 68 other GPCRs, ion channels and transporters, with an EC50 value of 190 nm with an Emax value of 148% in the presence of the known ligand BAM8-22.

storage

Store at RT

2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide Suppliers

China 29 United Kingdom 1 United States 6 USA 1 Global 37

TargetMol Chemicals Inc.

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1646499-97-9, 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamideRelated Search:

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2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide

ML 382

Benzamide, 2-[(cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)-

ML382,Inhibitor,ML 382,nociceptor,pain,injury,DRG,inhibit,neurons,nervous,ML-382

2-cyclopropanesulfonamido-N-(2-ethoxyphenyl)benzamide

ML382, 10 mM in DMSO

1646499-97-9