ChemicalBook > CAS DataBase List > Chloropyramine hydrochloride

Chloropyramine hydrochloride

Product Name
Chloropyramine hydrochloride
CAS No.
6170-42-9
Chemical Name
Chloropyramine hydrochloride
Synonyms
CHLOROPYRAMINE HCL;Chloropyramine HCI;Nilfan;Alergosan;Halopyramine hydrochloride;CHLOROPYRAMINE HYDROCHLORIDE;CHLOROPYRAMINE MONOHYDROCHLORIDE;Chloropyramine hydrochloride salt;3-chloro-2H-pyran-2-amine hydrochloride;N-P-CHLOROBENZYL-N,N-DIMETHYL-N-(2-PYRIDYL)ETHYLENEDIAMINE HYDROCHLORIDE
CBNumber
CB4495475
Molecular Formula
C16H21Cl2N3
Formula Weight
326.26
MOL File
6170-42-9.mol
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Chloropyramine hydrochloride Property

Melting point:
172-174°
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
color 
White to Off-White
CAS DataBase Reference
6170-42-9(CAS DataBase Reference)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C1915
Product name
Chloropyramine hydrochloride
Purity
analytical standard, for drug analysis
Packaging
1g
Price
$14.4
Updated
2024/03/01
Alfa Aesar
Product number
J60350
Product name
Chloropyramine hydrochloride
Packaging
1g
Price
$32.65
Updated
2024/03/01
TRC
Product number
C381268
Product name
Chloropyramine hydrochloride
Packaging
1g
Price
$125
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0001961
Product name
CHLOROPYRAMINE HYDROCHLORIDE
Purity
95.00%
Packaging
1G
Price
$131.25
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC149051
Product name
Chloropyramine HCl
Packaging
5G
Price
$150
Updated
2021/12/16
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Chloropyramine hydrochloride Chemical Properties,Usage,Production

Originator

Chloropyramine,Vramed

Uses

synthetic

Uses

Chloropyramine hydrochloride is a neurotransmitter related agent for research of drug analysis. Also, it is designed to disrupt the focal adhesion kinase (FAK) and vascular endothelial growth factor receptor-3 (VEGFR-3) interaction in neuroblastoma.

Manufacturing Process

A solution comprising 40 parts of 2-bromopyridine, 100 parts of N,N-dimethylN'-(4-chlorobenzyl)ethylenediamine and 100 parts of quinoline is heated at 140-145°C for 5 hours. The oil layer after washing with 30% sodium hydroxide solution is distilled, and the fraction which distills at 142-170°C/1 mm is collected. This oil is converted to the monohydrochloride and recrystallized from a mixture of amyl alcohol and ether. The monohydrochloride salt of N,N-dimethyl-N'-(4-chlorobenzyl)-N'-(2-pyridyl) ethylenediamine is obtained which melts at 167-168.4°C.
N,N-Dimethyl-N'-(4-chlorobenzyl)-N'-(2-pyridyl)ethylenediamine may be prepared by another method:
To a mixture of 100 ml of liquid ammonia and about 80 mg of black iron oxide was added 0.78 g (0.02 atom) of potassium. When all of the potassium had reacted, 3.3 g of N,N-dimethyl-N'-(2-pyridyl)ethylenediamine was added. After the addition of 75 ml of dry toluene the ammonia was removed on the steam bath. To the cooled and stirred mixture was added 4.26 g of p-chlorobenzyl chloride, and the reaction mixture was stirred on the steam bath for 11 hours. It was then filtered and concentrated to an oil. This concentrate was taken up in ether, and the ethereal solution was washed with water, dried over sodium sulfate, and concentrated. Distillation gave 2.96 g of yellow liquid. Treatment of this distillate with an equivalent quantity of hydrogen chloride in absolute alcohol and precipitation by the addition of anhydrous ether gave 2.33 g of the N,N-dimethyl-N'-(4-chlorobenzyl)-N'-(2-pyridyl)ethylenediamine hydrochloride.

Therapeutic Function

Antihistaminic

Chloropyramine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Chloropyramine hydrochloride Suppliers

China 61 Germany 2 India 4 Switzerland 3 United Kingdom 5 United States 18 USA 1 Global 94
Guangzhou Isun Pharmaceutical Co., Ltd
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View Lastest Price from Chloropyramine hydrochloride manufacturers

Henan Fengda Chemical Co., Ltd
Product
Chloropyramine hydrochloride 6170-42-9
Price
US $50.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-22
Career Henan Chemical Co
Product
Chloropyramine hydrochloride 6170-42-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-11

6170-42-9, Chloropyramine hydrochlorideRelated Search:

ETHANE Chloropyramine Pioglitazone hydrochloride Ethylenediamine dihydrochloride Cefeprime dihydrochloride Methoxyammonium chloride N,N-Dimethylformamide N,N,N',N'-Tetramethylethylenediamine Metoclopramide hydrochloride Pyridine hydrochloride Topotecan hydrochloride Dimethyl carbonate Dimethyl ether Dimethyl fumarate Dimethyl sulfoxide 2,6-Lutidine Triprolidine hydrochloride TRIPELENNAMINE HYDROCHLORIDE

  • CHLOROPYRAMINE HCL
  • CHLOROPYRAMINE HYDROCHLORIDE
  • CHLOROPYRAMINE MONOHYDROCHLORIDE
  • N-P-CHLOROBENZYL-N,N-DIMETHYL-N-(2-PYRIDYL)ETHYLENEDIAMINE HYDROCHLORIDE
  • N-P-CHLOROBENZYL-N',N'-DIMETHYL-N-[2-PYRIDYL]ETHYLENEDIAMINE HYDROCHLORIDE
  • N-P-CHLOROBENZYL-N',N'-DIMETHYL-N-[2-PYRIDYL]LETHYLENEDIAMINE HYDROCHLORIDE
  • N1-(4-Chlorobenzyl)-N2,N2-dimethyl-N1-(pyridin-2-yl)ethane-1,2-diamine hydrochloride
  • Chloropyramine HCI
  • N-[(4-chlorophenyl)methyl]-N’,N’-dimethyl-N-2-pyridinyl-1,2-ethanediamine
  • 3-chloro-2H-pyran-2-amine hydrochloride
  • Chloropyramine hydrochloride salt
  • Nilfan
  • Halopyramine hydrochloride
  • Alergosan
  • Vascular endothelial growth factor receptor,FAK,inhibit,PTK2,Chloropyramine hydrochloride,VEGFR,Chloropyramine,Focal adhesion kinase,PTK2 protein tyrosine kinase 2,Histamine Receptor,Inhibitor
  • N'-[(4-chlorophenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine,hydrochloride
  • 6170-42-9
  • C16H20ClN3HCl
  • C16H20ClN3ClH
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