NU 2058

Product Name: NU 2058
CAS No.: 161058-83-9
Chemical Name: NU 2058
Synonyms: CS-2601;NU2058>2-aMino-6-purine;NU2058, 10 mM in DMSO;NU 2058;NU-2058;NU2058;O-Cyclohexylmethylguanine;2-Amino-6-(cyclohexylmethoxy)purine;NU-2058;O6-(CYCLOHEXYLMETHYL)GUANINE;6-(Cyclohexylmethoxy)-9H-purin-2-amine;2-aMino-6-[(cyclohexylMethyl)oxy]purine
CBNumber: CB4498289
Molecular Formula: C12H17N5O
Formula Weight: 247.3
MOL File: 161058-83-9.mol

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NU 2058 Property

Melting point:: 199°C(lit.)
Boiling point:: 424.8±55.0 °C(Predicted)
Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMSO: 22 mg/mL
pka: 7.36±0.20(Predicted)
form: powder to crystal
color: white
λmax: 281nm(MeOH)(lit.)
InChIKey: MWGXGTJJAOZBNW-UHFFFAOYSA-N

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37
WGK Germany: 3
HS Code: 2933.99.9000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N4286
Product name: NU 2058
Purity: >98% (HPLC)
Packaging: 5mg
Price: $84.8
Updated: 2024/03/01

TCI Chemical

Product number: N0958
Product name: NU 2058
Purity: >98.0%(HPLC)
Packaging: 20mg
Price: $141
Updated: 2024/03/01

TCI Chemical

Product number: N0958
Product name: NU 2058
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $490
Updated: 2024/03/01

Cayman Chemical

Product number: 21415
Product name: NU 2058
Purity: ≥98%
Packaging: 5mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 21415
Product name: NU 2058
Purity: ≥98%
Packaging: 10mg
Price: $106
Updated: 2024/03/01

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NU 2058 Chemical Properties,Usage,Production

Description

NU 2058 is an inhibitor of cyclin-dependent kinase 1 (Cdk1) and Cdk2 (IC₅₀s = 7.0 and 17 μM, respectively). Increased Cdk activity is often associated with human tumors, and inhibitors of Cdks, including NU 2058, can arrest cell cycling in cancer cells in vitro.

Uses

NU 2058 is an intermediate of NU 6140 (N925295), a cyclin-dependant kinase 2 inhibitor which demonstrates 10-36 fold selectivity against Cdk2-cyclin A. This selectivity induces cell-cycle arrest at the G2-M phase and potentiates the apoptotic effect of pacitaxel.

Biological Activity

Cyclin-dependent kinase (cdk) 1 and cdk2 inhibitor (K i values are 5 and 12 μ M respectively). Inhibits growth of human tumor cells in vitro (mean GI 50 = 13 μ M). Also inhibits DNA topoisomerase II ATPase activity (IC 50 = 300 μ M).

storage

Store at +4°C

NU 2058 Preparation Products And Raw materials

Raw materials

Preparation Products

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NU 2058 Suppliers

Americas 1 China 72 Europe 1 India 2 Japan 1 Switzerland 2 United Kingdom 2 United States 18 Global 99

VDM Biochemicals

Tel: 0330-2528181
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MedChemexpress LLC

Tel: 021-58955995
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EMMX Biotechnology LLC

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Musechem

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InvivoChem

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Fax: 708-557-7486
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Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
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Alchem Pharmtech,Inc.

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Aladdin Scientific

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TargetMol Chemicals Inc.

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3B Scientific Corporation

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MedChemExpress

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Combi-Blocks Inc.

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Matrix Scientific

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Santa Cruz Biotechnology, Inc.

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SynInnova Laboratories Inc.

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View Lastest Price from NU 2058 manufacturers

Career Henan Chemical Co

Product: NU 2058 161058-83-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2020-01-14

161058-83-9, NU 2058Related Search:

Roscovitine PD0332991 Isethionate Mesitylene-2-sulfonyl chloride BUTYROLACTONE I PROSTAGLANDIN A2 Flavopiridol Cdk Inhibitor, p35 Palbociclib H-ALA-ASP-ALA-GLN-HIS-ALA-THR-PRO-PRO-LYS-LYS-LYS-ARG-LYS-VAL-GLU-ASP-PRO-LYS-ASP-PHE-OH BML-259 6-Methoxyguanine 6-N-PROPOXYPURINE NU6140 6-N-BUTOXYPURINE 6-ETHOXYPURINE NU 2058 NU6102

CS-2601

NU 2058;NU-2058;NU2058

6-(Cyclohexylmethoxy)-9H-purin-2-amine

2-aMino-6-purine

2-aMino-6-[(cyclohexylMethyl)oxy]purine

2-Amino-6-(cyclohexylmethoxy)purine

NU-2058;O6-(CYCLOHEXYLMETHYL)GUANINE

NU2058&gt

9H-Purin-2-amine, 6-(cyclohexylmethoxy)-

O-Cyclohexylmethylguanine

CDK,NU 2058,guanine-based,inhibit,NU2058,Cyclin dependent kinase,anti-cancer,competitive,Inhibitor,ATP,NU-2058

NU2058, 10 mM in DMSO

161058-83-9

C12H17N5O

Protein Kinase

Cell Cycle Regulation