3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]-

Product Name: 3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]-
CAS No.: 1922098-69-8
Chemical Name: 3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]-
Synonyms: CCG-222740 ，S6673;CCG-222740, 10 mM in DMSO;N-(4-Chlorophenyl)-5,5-difluoro-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide;3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]-;Rho-associated kinase,CCG222740,Rho-kinase,Rho,CCG-222740,CCG 222740,Inhibitor,inhibit,muscle,actin,factor,MRTF,transcription,ROK,metastasis,protein,Rho-associated protein kinase,myocardin-related,fibrosis,Ras,melanoma,orally,expression,ROCK,alpha-smooth
CBNumber: CB45488948
Molecular Formula: C23H19ClF2N2O3
Formula Weight: 444.86
MOL File: 1922098-69-8.mol

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3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- Property

Boiling point:: 657.1±55.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:107.0(Max Conc. mg/mL);240.52(Max Conc. mM)
Ethanol:89.0(Max Conc. mg/mL);200.06(Max Conc. mM)
form: Solid
pka: 13.69±0.70(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Axon Medchem

Product number: Axon3069
Product name: CCG-222740
Purity: 98%
Packaging: 5mg
Price: $159.5
Updated: 2021/12/16

Axon Medchem

Product number: Axon3069
Product name: CCG-222740
Purity: 98%
Packaging: 2x5mg
Price: $264
Updated: 2021/12/16

ChemScene

Product number: CS-0083153
Product name: CCG-222740
Purity: 99.56%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0083153
Product name: CCG-222740
Purity: 99.56%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

Axon Medchem

Product number: Axon3069
Product name: CCG-222740
Purity: 98%
Packaging: 25mg
Price: $599.5
Updated: 2021/12/16

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3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- Chemical Properties,Usage,Production

Uses

CCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor[1]. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis[2].

in vivo

CCG-222740 (oral gavage; 100 mg/kg/day for 7 days) significantly reduces α-SMA levels in the pancreas of caerulein-stimulated KC mice^[1].

Animal Model:	KC mice (LSL-Kras^G12D/+; Pdx-1-Cre) of age at 9 weeks^[1]
Dosage:	100?mg/kg
Administration:	Oral gavage; daily; for 7 days
Result:	Reduced α-SMA levels in the pancreas of caerulein-stimulated KC mice.

References

[1] Leal AS, et al. The Rho/MRTF pathway inhibitor CCG-222740 reduces stellate cell activation and modulates immune cell populations in KrasG12D; Pdx1-Cre (KC) mice. Sci Rep. 2019 May 8;9(1):7072. DOI:10.1038/s41598-019-43430-0
[2] Yu-Wai-Man C, et al. Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis. Sci Rep. 2017 Mar 31;7(1):518. DOI:10.1038/s41598-017-00212-w

3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- Preparation Products And Raw materials

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Preparation Products

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3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- Suppliers

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1922098-69-8, 3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]-Related Search:

CCT128930 CC-122 CCT 137690 CCG215022 CC-92480 CC-885 CCT245737 CCF-642

3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]-

Rho-associated kinase,CCG222740,Rho-kinase,Rho,CCG-222740,CCG 222740,Inhibitor,inhibit,muscle,actin,factor,MRTF,transcription,ROK,metastasis,protein,Rho-associated protein kinase,myocardin-related,fibrosis,Ras,melanoma,orally,expression,ROCK,alpha-smooth

N-(4-Chlorophenyl)-5,5-difluoro-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide

CCG-222740, 10 mM in DMSO

CCG-222740 ，S6673

1922098-69-8

C23H19ClF2N2O3