ChemicalBook > CAS DataBase List > 3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]-

3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]-

Product Name
3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]-
CAS No.
1922098-69-8
Chemical Name
3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]-
Synonyms
CCG-222740 ，S6673;CCG-222740, 10 mM in DMSO;N-(4-Chlorophenyl)-5,5-difluoro-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide;3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]-;Rho-associated kinase,CCG222740,Rho-kinase,Rho,CCG-222740,CCG 222740,Inhibitor,inhibit,muscle,actin,factor,MRTF,transcription,ROK,metastasis,protein,Rho-associated protein kinase,myocardin-related,fibrosis,Ras,melanoma,orally,expression,ROCK,alpha-smooth
CBNumber
CB45488948
Molecular Formula
C23H19ClF2N2O3
Formula Weight
444.86
MOL File
1922098-69-8.mol
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3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- Property

Boiling point:
657.1±55.0 °C(Predicted)
Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:107.0(Max Conc. mg/mL);240.52(Max Conc. mM)
Ethanol:89.0(Max Conc. mg/mL);200.06(Max Conc. mM)
form 
Solid
pka
13.69±0.70(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Axon Medchem
Product number
Axon3069
Product name
CCG-222740
Purity
98%
Packaging
5mg
Price
$159.5
Updated
2021/12/16
Axon Medchem
Product number
Axon3069
Product name
CCG-222740
Purity
98%
Packaging
2x5mg
Price
$264
Updated
2021/12/16
ChemScene
Product number
CS-0083153
Product name
CCG-222740
Purity
99.56%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0083153
Product name
CCG-222740
Purity
99.56%
Packaging
10mg
Price
$550
Updated
2021/12/16
Axon Medchem
Product number
Axon3069
Product name
CCG-222740
Purity
98%
Packaging
25mg
Price
$599.5
Updated
2021/12/16
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3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- Chemical Properties,Usage,Production

Uses

CCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor[1]. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis[2].

in vivo

CCG-222740 (oral gavage; 100 mg/kg/day for 7 days) significantly reduces α-SMA levels in the pancreas of caerulein-stimulated KC mice[1].

Animal Model:KC mice (LSL-KrasG12D/+; Pdx-1-Cre) of age at 9 weeks[1]
Dosage:100?mg/kg
Administration:Oral gavage; daily; for 7 days
Result:Reduced α-SMA levels in the pancreas of caerulein-stimulated KC mice.

References

[1] Leal AS, et al. The Rho/MRTF pathway inhibitor CCG-222740 reduces stellate cell activation and modulates immune cell populations in KrasG12D; Pdx1-Cre (KC) mice. Sci Rep. 2019 May 8;9(1):7072. DOI:10.1038/s41598-019-43430-0
[2] Yu-Wai-Man C, et al. Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis. Sci Rep. 2017 Mar 31;7(1):518. DOI:10.1038/s41598-017-00212-w

3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- Suppliers

China 32 United States 4 Global 36
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1922098-69-8, 3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]-Related Search:

CCT128930 CC-122 CCT 137690 CCG215022 CC-92480 CC-885 CCT245737 CCF-642

  • 3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]-
  • Rho-associated kinase,CCG222740,Rho-kinase,Rho,CCG-222740,CCG 222740,Inhibitor,inhibit,muscle,actin,factor,MRTF,transcription,ROK,metastasis,protein,Rho-associated protein kinase,myocardin-related,fibrosis,Ras,melanoma,orally,expression,ROCK,alpha-smooth
  • N-(4-Chlorophenyl)-5,5-difluoro-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide
  • CCG-222740, 10 mM in DMSO
  • CCG-222740 ，S6673
  • 1922098-69-8
  • C23H19ClF2N2O3