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HUMAN FIBRINOGEN

Product Name
HUMAN FIBRINOGEN
CAS No.
9001-32-5
Chemical Name
HUMAN FIBRINOGEN
Synonyms
C00393;factor i;factor 1;Parenogen;FIBRINOGEN;fibrinogens;Fibrinogen HUMAN FIBRINOGEN;FIBRINOGEN TYPE I;BOVINE FIBRINOGEN
CBNumber
CB4683502
Molecular Formula
C6H14O6
Formula Weight
182.17176
MOL File
9001-32-5.mol
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HUMAN FIBRINOGEN Property

storage temp. 
-20°C
solubility 
0.9% NaCl: soluble
form 
powder
color 
white
EPA Substance Registry System
Fibrinogens (9001-32-5)
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Safety

Hazard Codes 
B
WGK Germany 
3
10-21
TSCA 
Yes
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
341576-M
Product name
Fibrinogen, Human Plasma
Purity
Fibrinogen, CAS 9001-32-5, is a soluble plasma glycoprotein that is synthesized in the hepatic parenchymal cells. Contains >90% clottable protein.
Packaging
100mg
Price
$90.9
Updated
2024/03/01
Sigma-Aldrich
Product number
341576-M
Product name
Fibrinogen, Human Plasma
Purity
Fibrinogen, CAS 9001-32-5, is a soluble plasma glycoprotein that is synthesized in the hepatic parenchymal cells. Contains >90% clottable protein.
Packaging
1g
Price
$361
Updated
2024/03/01
Sigma-Aldrich
Product number
341573
Product name
Fibrinogen, Bovine Plasma
Purity
Fibrinogen, CAS 9001-32-5, is a soluble plasma glycoprotein that is synthesized in the hepatic parenchymal cells. Contains mpre than 95% clottable protein.
Packaging
1g
Price
$261
Updated
2024/03/01
Sigma-Aldrich
Product number
341576-M
Product name
Fibrinogen, Human Plasma
Purity
Fibrinogen, CAS 9001-32-5, is a soluble plasma glycoprotein that is synthesized in the hepatic parenchymal cells. Contains >90% clottable protein.
Packaging
341576-100MG
Price
$85.8
Updated
2023/06/20
Alfa Aesar
Product number
J63276
Product name
Fibrinogen, bovine
Packaging
1g
Price
$59
Updated
2023/06/20
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HUMAN FIBRINOGEN Chemical Properties,Usage,Production

Chemical Properties

White or grayish amorphous substance.

Uses

A soluble plasma glycoprotein, produced by the liver, that is converted by thrombin into fibrin during the blood coagulation process. Fibrinogen is a natural blood protein involved in the coagulation process. It is used instead of traditional sources of fibrinogen such as the blood products, fresh frozen plasma and cryoprecipitate. It helps in blood clot formation.

Uses

Diagnostic aid (vascular patency); radioactive agent.

Uses

Fibrinogen from rat plasma has been used:

  • in the preparation of growth factor solutions
  • to apply on discontinuous SDS-polyacrylamide gels for the detection of IgG (immunoglobulins) type antibodies by immunoblot analysis
  • to mix with cell suspension to form a clot and retain the cells for avoiding its dispersion during transplantation

Definition

A sterile fraction of normal human blood plasma, dried from the frozen state. In solution, it has the property of being converted into insoluble fibrin when thrombin is added. It is an essential factor in the blood-clotting mechanism.

General Description

Fibrinogen, or Factor I, is a blood protein that is involved in clotting and is converted to fibrin by thrombin. Fibrinogen has an approximate molecular weight of 340 kDa

Biochem/physiol Actions

Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolyses fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa, that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source.

Purification Methods

A likely impurity is plasminogen. It is purified by glycine precipitation [Mosesson & Sherry Biochemistry 5 2829 1966] to obtain fractions 1-2, then further purified [Blomb.ck & Blomb.ck Arkiv Kemi 10 415 1956] and contaminating plasminogen is removed by passage through a lysine-Sepharose column. Such preparations are at least 95% clottable as determined by Mosesson and Sherry's method (above ref.) in which the OD280 is measured before and after clotting with 5 Units/mL of thrombin (> 3000U/mg). All fibrinogen preparations are treated with calf intestinal alkaline phosphatase to convert any fibrinogen peptide-AP to fibrinogen peptide-A by removing serine-bound phosphate. Solutions are then lyophilised and stored at -20o. [Higgins & Shafer J Biol Chem 256 12013 1981.] It is sparingly soluble in H2O. Aqueous solutions are viscous with isoelectric point at pH 5.5. It is readily denatured by heating above 56o or by chemical agents, e.g. salicylaldehyde, naphthoquinone sulfonates, ninhydrin or alloxan. [Edsall et al. J Am Chem Soc 69 2731 1947, Purification: Cama et al. Naturwissenschaften 48 574 1961, Lorand & Middlebrook Science 118 515 1953, cf. Fuller in Methods Enzymol 163 474 1988.] For plasminogen-deficient fibrinogen from blood plasma, the anticoagulated blood is centrifuged and the plasma is frozen and washed with saline solution. It is treated with charcoal, freeze-thawed and dialysed versus Tris/NaCl buffer. [Maxwell & Nikel Biochemical Preparations 12 16 1968.]

HUMAN FIBRINOGEN Preparation Products And Raw materials

Raw materials

Preparation Products

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HUMAN FIBRINOGEN Suppliers

Shanghai Baoman Biotechnology Co., Ltd.
Tel
021-62130998
Fax
021-54438215
Email
baomanbio@163.com
Country
China
ProdList
108
Advantage
55
JiangSu Star Science Co.,Ltd
Tel
400-400-605-7200-7200 17312445705
Email
sales022@b2star.com
Country
China
ProdList
3761
Advantage
58
Hu' nan Yunbang Pharmaceutical Co., Ltd.
Tel
0731-85561037 15386497078
Email
yunbang@yunbangapi.com
Country
China
ProdList
4819
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Wuhan Sunrise Technology Development Co., Ltd.
Tel
27-027-83314682 13554138826
Fax
+86 (27) 8331-4682
Email
whsrtech@vip.163.com
Country
China
ProdList
230
Advantage
62
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
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View Lastest Price from HUMAN FIBRINOGEN manufacturers

Watson Biotechnology Co.,Ltd
Product
Fibrinogen from bovine plasma 9001-32-5
Price
US $0.00-0.00/G
Min. Order
1G
Purity
93%
Supply Ability
100G
Release date
2024-08-10
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Fibrinogen 9001-32-5
Price
US $0.00/g
Min. Order
1g
Purity
98.0%
Supply Ability
500g/month
Release date
2021-12-13
Hebei Weibang Biotechnology Co., Ltd
Product
Human fibrinogen 9001-32-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28

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