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5-Aminoisophthalic acid

Description Reference
Product Name
5-Aminoisophthalic acid
CAS No.
99-31-0
Chemical Name
5-Aminoisophthalic acid
Synonyms
5-AMINOISOPHTHALIC;5-AIPA;5-AMINOISOPHTHALATE;5-AMINOISOPHTHALIC ACID HYDRATE;5-AminoisophthaL;3,5-Dicarboxyaniline.;5-amino-m-phthalic Acid;AMINOISOPHTHALIC(5-) ACID;5-Aminoisophthalicacid,95%;5-AMINO-1,3-ISOPHTHALIC ACID
CBNumber
CB4689650
Molecular Formula
C8H7NO4
Formula Weight
181.15
MOL File
99-31-0.mol
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5-Aminoisophthalic acid Property

Melting point:
>300 °C (lit.)
Boiling point:
314.24°C (rough estimate)
Density 
1.4283 (rough estimate)
refractive index 
1.5468 (estimate)
storage temp. 
Store below +30°C.
pka
3.69±0.10(Predicted)
form 
Granular Powder
color 
White to cream
Water Solubility 
INSOLUBLE
BRN 
2805628
InChI
InChI=1S/C8H7NO4/c9-6-2-4(7(10)11)1-5(3-6)8(12)13/h1-3H,9H2,(H,10,11)(H,12,13)
InChIKey
KBZFDRWPMZESDI-UHFFFAOYSA-N
SMILES
C1(C(O)=O)=CC(N)=CC(C(O)=O)=C1
CAS DataBase Reference
99-31-0(CAS DataBase Reference)
EPA Substance Registry System
5-Aminoisophthalic acid (99-31-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
F 
9
TSCA 
Yes
HS Code 
29224995
Toxicity
LD50 orally in Rabbit: 1600 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
186279
Product name
5-Aminoisophthalic acid
Purity
94%
Packaging
25g
Price
$39
Updated
2025/07/31
Sigma-Aldrich
Product number
8.01246
Product name
5-Aminoisophthalic acid
Purity
for synthesis
Packaging
50g
Price
$57.3
Updated
2025/07/31
Sigma-Aldrich
Product number
186279
Product name
5-Aminoisophthalic acid
Purity
94%
Packaging
100g
Price
$66.55
Updated
2025/07/31
TCI Chemical
Product number
A1290
Product name
5-Aminoisophthalic Acid Hydrate
Purity
>98.0%(T)
Packaging
25g
Price
$31
Updated
2025/07/31
TCI Chemical
Product number
A1290
Product name
5-Aminoisophthalic Acid Hydrate
Purity
>98.0%(T)
Packaging
100g
Price
$81
Updated
2025/07/31
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5-Aminoisophthalic acid Chemical Properties,Usage,Production

Description

It is usually used as the intermediate or raw material in the organic synthesis. For example, this chemical can be selected as the raw material to prepare three lanthanide metal organic frameworks (MOFs) with typical structural features of one-dimensional ladder-like chain, two-dimensional layer, and three-dimensional framework.1 Moreover, this substance is chosen as the reactant to fabricate new metal complexes with 5-(1H-imidazol-4-ylmethyl)aminoisophthalic acid, which have good electrocatalytic activities toward the reduction of H2O2 in phosphate buffer (pH=5.5) solution.2 In addition, as the active reactant, this chemical has been demonstrated to assist in the synthesis of a chiral, radically homopolymerizable methacrylamide dendrimer with eight ester groups.3

Reference

  1. Jin, H. G.; Yan, Y. Z.; Li, J.; Gu, Z. G.; Chen, J. H.; Liu, Y. T.; Zheng, Z. P.; Zhan, Q. G.; Cai, Y. P., 1-D to 3-D lanthanide coordination polymers constructed from 5-aminoisophthalic acid and oxalic acid. Inorg. Chem. Commun. 2012, 23, 25-30.
  2. Xu, J.; Su, Z.; Chen, M. S.; Chen, S. S.; Sun, W. Y., New metal complexes with 5-(1H-imidazol-4-ylmethyl)aminoisophthalic acid: Syntheses, structures, electrochemistry and electrocatalysis. Inorg. Chim. Acta 2009, 362, 4002-4008.
  3. Draheim, G.; Ritter, H., POLYMERIZABLE DENDRIMERS SYNTHESIS OF A SYMMETRICALLY BRANCHED METHACRYL DERIVATIVE BEARING 8 ESTER GROUPS. Macromol. Chem. Phys. 1995, 196, 2211-2222.

Chemical Properties

Light beige-brown crystalline powder

Uses

5-Aminoisophthalic acid is a useful biochemical for proteomics research.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

618-88-2

99-31-0

In a 3L four-neck flask equipped with a mechanical stirrer, 211.1 g (1.0 mol, 1.0 eq.) of 5-nitroisophthalic acid and 160.0 g (4.0 mol, 4.0 eq.) of sodium hydroxide were dissolved in 2L of water. A thermometer was installed and the mixture was stirred for 1 hour until the system was clarified. Subsequently, 10 g of Nguyenay nickel was added and the temperature was slowly raised to 30-35°C. At this temperature, 125.0 g (2.0 mol, 2.0 eq.) of 80% hydrazine hydrate was added dropwise for a controlled drop time of 30 minutes. After dropwise addition, stirring was continued for 30 min to ensure complete reaction. At the end of the reaction, the pH of the filtrate was adjusted to 3.5-4.0 with acetic acid and a large amount of white solid was precipitated. The precipitate was collected by filtration and dried to give 172.0 g of 5-aminoisophthalic acid in 95% yield and 99.7% purity.

References

[1] Nucleosides and Nucleotides, 1999, vol. 18, # 2, p. 291 - 305
[2] Patent: CN106748840, 2017, A. Location in patent: Paragraph 0020; 0021; 0022; 0023; 0024; 0025
[3] Justus Liebigs Annalen der Chemie, 1870, vol. 153, p. 285
[4] Journal fuer Praktische Chemie (Leipzig), 1882, vol. <2> 25, p. 491
[5] Chemische Berichte, 1917, vol. 50, p. 448

5-Aminoisophthalic acid Preparation Products And Raw materials

Raw materials

Preparation Products

pigment yellow 155
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View Lastest Price from 5-Aminoisophthalic acid manufacturers

Jinan Finer Chemical Co., Ltd
Product
5-Aminoisophthalic acid 99-31-0
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
500mt/year
Release date
2021-07-28
Hebei Zhuanglai Chemical Trading Co Ltd
Product
5-Aminoisophthalic acid 99-31-0
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-17
Asia Chem I and E (Jiangsu) Co Ltd
Product
5-Aminoisophthalic acid 99-31-0
Price
US $34.88/Kg/Drum
Min. Order
25Kg/Drum
Purity
99.00%HPLC
Supply Ability
5tons/month
Release date
2021-09-22

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