BOC-L-Isoleucine

Product Name: BOC-L-Isoleucine
CAS No.: 13139-16-7
Chemical Name: BOC-L-Isoleucine
Synonyms: BOC-ILE-OH;Boc-L-lle-OH;N-Boc-L-isoleucine;BOC-L-Ile;BOC-ISOLEUCINE;Boc-L-Isovaline;N-(tert-Butyloxycarbonyl)-L-isoleucine;Boc-lIe-OH;Boc-IIe-OH;Boc-Ile-OH1
CBNumber: CB4690221
Molecular Formula: C11H21NO4
Formula Weight: 231.29
MOL File: 13139-16-7.mol

More

Less

BOC-L-Isoleucine Property

Melting point:: 66-69 °C(lit.)
alpha: 2 º (c=2,CH3COOH)
Boiling point:: 373.37°C (rough estimate)
Density: 1.1202 (rough estimate)
refractive index: 2.7 ° (C=2, AcOH)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Acetic Acid, DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 4.03±0.22(Predicted)
color: White to Off-White
optical activity: [α]20/D +2.7°, c = 2 in acetic acid
Water Solubility: Soluble in methanol. Insoluble in water.
BRN: 1711700
CAS DataBase Reference: 13139-16-7(CAS DataBase Reference)
EPA Substance Registry System: L-Isoleucine, N-[(1,1-dimethylethoxy)carbonyl]- (13139-16-7)

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 24/25-36-26
WGK Germany: 3
TSCA: Yes
HS Code: 29241990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 359653
Product name: Boc-Ile-OH
Purity: 98%
Packaging: 25g
Price: $128
Updated: 2025/07/31

TCI Chemical

Product number: B1186
Product name: N-(tert-Butoxycarbonyl)-L-isoleucine Hemihydrate
Purity: >99.0%(T)
Packaging: 5g
Price: $32
Updated: 2025/07/31

TCI Chemical

Product number: B1186
Product name: N-(tert-Butoxycarbonyl)-L-isoleucine Hemihydrate
Purity: >99.0%(T)
Packaging: 25g
Price: $79
Updated: 2025/07/31

TRC

Product number: B657225
Product name: N-Boc-L-isoleucine
Packaging: 100g
Price: $200
Updated: 2021/12/16

Usbiological

Product number: 458374
Product name: N-Boc-L-isoleucine
Packaging: 10g
Price: $312
Updated: 2021/12/16

More

Less

BOC-L-Isoleucine Chemical Properties,Usage,Production

Chemical Properties

white fine crystalline powder

Uses

N-Boc-L-isoleucine is used to prepare BOC-L-isoleucine hydroxysuccinimide ester by using 1-hydroxybenzotriazole and 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride.

reaction suitability

reaction type: Boc solid-phase peptide synthesis
reaction type: C-H Activation
reagent type: ligand
reaction type: Peptide Synthesis

Synthesis

73-32-5

24424-99-5

13139-16-7

GENERAL STEPS: L-isoleucine (1.31 g, 10 mmol, 1.0 equiv) was dissolved in 20.5 mL of 1 M NaOH solution and cooled in an ice bath. Di-tert-butyl dicarbonate (Boc2O, 2.62 g, 12 mmol, 1.2 equiv) dissolved in 7 mL of dioxane was added slowly. The reaction mixture was stirred at ambient temperature for 24 hours. Subsequently, the pH of the reaction solution was adjusted to 10 with 1 M NaOH and ether was added for phase separation. The aqueous phase was acidified to pH 2 with 1 M HCl and extracted with ethyl acetate (EtOAc). The combined organic phases were washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to give BOC-L-isoleucine as a colorless oil (2.20 g, 95% yield). IR (cm-1): 3292 (w), 2967 (m), 2934 (w), 2880 (w), 1713 (s), 1661 (m), 1504 (m), 1465 (w), 1394 (m), 1368 (s), 1242 (m), 1159 (s), 1121 (m), 1046 (m), 1019 (w), 857 (w), 778 857 (w), 778 (w), 657 (w). 1H NMR (500 MHz, CDCl3) δ: 0.94 (t, J = 7.3 Hz, 3H, H-6), 0.98 (d, J = 7 Hz, 3H, H-4), 1.15-1.29 (m, 1H, H-5a), 1.46 (s, 9H, H-9/10/11), 1.46-1.54 (m, partially overlapped, 1H, H-5b), 1.83-1.99 (m, 1H, H-3), 4.30 (dd, J = 8.9, 4.6 Hz, 1H, H-2), 5.02 (d, J = 8.9 Hz, 1H, NH). 13C NMR (125 MHz, CDCl3) δ: 11.8 (C-6), 15.7 (C-4), 25.0 (C-5), 28.5 (C-9/10/11), 37.9 (C-3), 58.0 (C-2), 80.2 (C-8), 155.9 (C-7), 177.2 (C-1). HRMS (ESI) m/z: [M-H]- calcd for C11H20NO4 230.13868, found 230.13926. [α]20D +3.6 (c 2.00, CH3OH) (Lit [3]: [α]25D +3.8 (c 1.01, CH3OH)).

References

[1] Tetrahedron Letters, 2005, vol. 46, # 38, p. 6537 - 6540
[2] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 17, p. 6340 - 6350
[3] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 14, p. 3573 - 3586
[4] Tetrahedron, 1992, vol. 48, # 37, p. 8007 - 8022
[5] Tetrahedron, 2006, vol. 62, # 31, p. 7274 - 7283

BOC-L-Isoleucine Preparation Products And Raw materials

Raw materials

Hexane L-Isoleucine Di-tert-butyl dicarbonate tert-Butanol Ethyl acetate Acetic acid Sodium hydroxide

Preparation Products

More

Less

BOC-L-Isoleucine Suppliers

Americas 1 Belgium 1 China 275 Europe 4 France 2 Germany 8 Hungary 1 India 25 Japan 7 Poland 1 South Korea 1 Switzerland 5 United Kingdom 10 United States 51 Global 392

Shanghai Surseechem Scientific Co.,Ltd

Tel: 021-53393865 13661997311
Fax: 021-31159018
Email: sales@surseechem.cn
Country: China
ProdList: 20
Advantage: 56

Sichuan HongRi Pharma-Tech Co., Ltd

Tel: 02888457210; 18380436509
Fax: 0838-2822568
Email: 2065506070@qq.com
Country: China
ProdList: 2025
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

More

Less

View Lastest Price from BOC-L-Isoleucine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-Ile-OH 13139-16-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-11-16

Career Henan Chemical Co

Product: BOC-L-Isoleucine 13139-16-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2018-08-09

13139-16-7, BOC-L-Isoleucine Related Search:

(2R,3R)-2-Amino-3-methylpentanoic acid 1,1'-Carbonyldiimidazole tert-Butyl acetate L-Isoleucine tert-Butyl peroxyacetate DL-Isoleucine N-CARBOBENZOXY-DL-LEUCINE tert-Butanol CARBONYL SULFIDE Boc-L-Cyclopentylglycine (S)-TERT-BUTOXYCARBONYLAMINO-INDAN-1-YL-ACETIC ACID NICKEL CARBONYL Boc-N-Methyl-L-isoleucine Boc-L-Cyclohexylglycine BOC-ALLO-ISOLEUCINE BOC-D-ISOLEUCINE extrapure,N-T-BOC-D-ISOLEUCINE,N-ALPHA-T-BOC-D-ISOLEUCINE,BOC-D-ISOLEUCINE Boc-L-isoleucine amide L-Isovaline

BOC-L-ISOLEUCINE

BOC-L-ISOLEUCINE-OH

BOC-ISOLEUCINE

BOC-ILE-OH

N-(TERT-BUTOXYCARBONYL)-L-ISOLEUCINE

N-T-BOC-L-ISOLEUCINE

N-ALPHA-T-BOC-L-ISOLEUCINE

N-ALPHA-T-BUTOXYCARBONYL-L-ISOLEUCINE

L-Isoleucine, N-[(1,1-dimethylethoxy)carbonyl]-

(2S)-N-(tert-Butoxycarbonyl)-L-isoleucine

(2S,3S)-2-[(tert-Butyloxycarbonyl)amino]-3-methylpentanoic acid

N-(tert-Butoxycarbonyl)isoleucine

N-(tert-Butyloxycarbonyl)-L-isoleucine

BOC-L-ISOLEUCINE extrapure

N-(tert-Butoxycarbonyl)-L-isoleucine, Boc-L-isoleucine

N-(tert-Butoxycarbonyl)-L-isoleucine ,99%

(S)-N-BOC-ISOLEUCINE

L-ISOLEUCINE-N-T-BOC

BOC-L-Ile

Boc-lle-OH·1/2 H2O Boc-L-isoleucine heMihydrate

N-Boc-L-isoleucine Boc-Ile-OH

Boc-L-Isovaline

(2S,3S)-2-((tert-Butoxycarbonyl)aMino)-3-Methylpentanoic acid

(2S,3S)-2-((tert-Butoxycarbonyl)aMino)-3-Methylpentanoic acid/BOC-L-ILe-OH

Boc-L-Isoleucine, 95+%

Boc-Ile-OH1

Boc-Ile-OH 98%

Boc-(2S,3S)-2-amino-3-methylpentanoic acid

Boc-L-isoleucine≥ 99% (Assay)

Isoleucine, N-carboxy-, N-tert-butyl ester, L-

3-methyl-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]pentanoic acid hydrate

N-Boc-L-isoleucine

N-T-BOC-L-ISOLEUCINE CRYSTALLINE

N-(TERT-BUTOXYCARBONYL)-L-ISOLEUCINE, 98 %

Boc-Ile-OH.5H2O

n-[(1,1-dimethylethoxy)carbonyl]-l-isoleucin

BOC-L-Isoleucine, 99+%

Boc-lle-OH.1/2H2O

boc-ile-oh,0.5h20

Boc-L-lle-OH

N-ALPHA-T-BUTYLOXYCARBONYL-L-ISOLEUCINE SEMIHYDRATE

Boc-L-isoleucine· 1/2H2O

Boc-Isoleucine, 0.5 H2O

Boc-Ile-OH.H2O

N-tert-Butoxycarbonyl-L-isoleucine·1/2H2O

N-tert-Butoxycarbonyl-L-isoleucine monohydrate

N-Boc-L-isoleucine, 98+%

Boc-Ile-OH·&frac12H2O

Boc-L-isoleucine, Anhydrous

N-(tert-Butoxycarbonyl)-L-isoleucine Hemihydrate&gt

BOC-L-Isoleucine USP/EP/BP

N-(TERT-BUTOXYCARBONYL)-L-ISOLEUNICE HEM IHYDRATE

Boc-L-Isoleucin

Boc-lIe-OH

(Tert-butoxycarbonyl)-L-isoleucine

BOC-L-Isoleucine-OH 98%

Boc-Ile-OH/98%/13139-16-7

Boc-IIe-OH