Oxipurinol
- Product Name
- Oxipurinol
- CAS No.
- 2465-59-0
- Chemical Name
- Oxipurinol
- Synonyms
- Oxyprim;BW-55-5;NSC-76239;OXIPURINOL;OXYPURINOL;1,7-Dihydro-;Alloxanthine;Oxoallopurinol;Allopurinol Impurity5;Allopurinol Impurity 6
- CBNumber
- CB4709190
- Molecular Formula
- C5H4N4O2
- Formula Weight
- 152.11
- MOL File
- 2465-59-0.mol
Oxipurinol Property
- Melting point:
- 300 °C
- Boiling point:
- 274.55°C (rough estimate)
- Density
- 1.637
- refractive index
- 1.8500 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in DMSO.
- pka
- pKa 7.7 (Uncertain)
- form
- Powder
- color
- Light yellow
- BRN
- 139956
- Stability:
- Hygroscoipic
- CAS DataBase Reference
- 2465-59-0(CAS DataBase Reference)
- EPA Substance Registry System
- Oxypurinol (2465-59-0)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- O6881
- Product name
- Oxypurinol
- Purity
- ≥98% (HPLC)
- Packaging
- 100mg
- Price
- $227
- Updated
- 2024/03/01
- Product number
- 42688
- Product name
- Oxypurinol
- Purity
- analytical standard
- Packaging
- 10mg
- Price
- $99
- Updated
- 2022/05/15
- Product number
- L07160
- Product name
- 4,6-Dihydroxy-1H-pyrazolo[3,4-d]pyrimidine, 98+%
- Packaging
- 1g
- Price
- $72.65
- Updated
- 2024/03/01
- Product number
- L07160
- Product name
- 4,6-Dihydroxy-1H-pyrazolo[3,4-d]pyrimidine, 98+%
- Packaging
- 5g
- Price
- $238.65
- Updated
- 2024/03/01
- Product number
- 18716
- Product name
- Oxipurinol
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $115
- Updated
- 2024/03/01
Oxipurinol Chemical Properties,Usage,Production
Chemical Properties
Off White Solid
Uses
4,6-Dihydroxy-1H-pyrazolo[3,4-d]pyrimidine is an inhibitor to study the specificity and kinetics of xanthine oxidase. It is also used as an anti-inflammatory agent via inhibition of xanthine oxidase.
Uses
Oxypurinol, an allopurinol metabolite, is used as an inhibitor to study the specificity and kinetics of of xanthine oxidase(s). Oxypurinol is also used as an anti-inflammatory agent via inhibition of xanthine oxidase.
Uses
A metabolite of Allopurinol.
Definition
ChEBI: A pyrazolopyrimidine that is 4,5,6,7-tetrahydro-H-pyrazolo[3,4-d]pyrimidine substituted by oxo groups at positions 4 and 6.
Biological Activity
oxipurinol is a xanthine oxidoreductase inhibitor.xanthine oxidoreductase (xo), a complex molybdoflavoenzyme present in milk and many other tissues, has been studied for many years. xo is generally recognized as a critical enzyme in purine catabolism.
Biochem/physiol Actions
An allopurinol metabolite.
in vitro
allopurinol could be rapidly oxidized by xo to its active metabolite oxypurinol (both isosteres of hypoxanthine and xanthine, respectively), which also could inhibit xo. oxypurinol was identified as a noncompetitive inhibitor of xo; the formation of this compound was reported to be responsible for much of the pharmacological activity of allopurinol. moreover, both allopurinol and oxypurinol showed free radical scavenging effects in isolated hearts, and exerted cardioprotective effects despite no detectable xo activities [1].
in vivo
animal study found that in the vasculature of hypercholesterolemic rabbits, oxypurinol treatment led to a decrease in vascular free radical production [1].
References
[1] p. pacher, a. nivorozhkin and c. szabó. therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. pharmacological reviews 58(1), 87-114 (2006).
[2] day ro, graham gg, hicks m, mclachlan aj, stocker sl, williams km. clinical pharmacokinetics and pharmacodynamics of allopurinol and oxypurinol. clin pharmacokinet. 2007;46(8):623-44.
Oxipurinol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Oxipurinol manufacturers
- Product
- Oxipurinol 2465-59-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-10