ChemicalBook > CAS DataBase List > 4-Iodo-2-(trifluoromethyl)pyridine

4-Iodo-2-(trifluoromethyl)pyridine

Product Name
4-Iodo-2-(trifluoromethyl)pyridine
CAS No.
590371-73-6
Chemical Name
4-Iodo-2-(trifluoromethyl)pyridine
Synonyms
4-lodo-2-(trifluoromethyl)pyridine;4-IODO-2-(TRIFLUOROMETHYL)PYRIDINE;4-IODE-2-(TRIFLUOROMETHYL)PYRIDINE;2-(trifluoroMethyl)-4-iodopyridine;Pyridine,4-iodo-2-(trifluoromethyl)-;4-Iodo-2-(trifluoromethyl)pyridine97%;4-Iodo-2-(trifluoromethyl)pyridine 97%;4-Iodo-2-(trifluoromethyl)pyridine ISO 9001：2015 REACH;4-Iode-2-(trifluoromethyl)pyridine (not restricted/prohibited)(lab chemical)
CBNumber
CB4722177
Molecular Formula
C6H3F3IN
Formula Weight
272.99
MOL File
590371-73-6.mol
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4-Iodo-2-(trifluoromethyl)pyridine Property

Melting point:
24-26 °C
Boiling point:
206.2±35.0 °C(Predicted)
Density 
1.974g/ml
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
liquid
pka
-0.82±0.20(Predicted)
color 
Clear, colourless to pale yellow
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
I724775
Product name
4-Iodo-2-(trifluoromethyl)pyridine
Packaging
5G
Price
$295
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-K-42
Product name
4-Iodo-2-(trifluoromethyl)pyridine
Purity
95%
Packaging
5G
Price
$341
Updated
2021/12/16
Apolloscientific
Product number
PC8981
Product name
4-Iodo-2-(trifluoromethyl)pyridine
Purity
95%
Packaging
5g
Price
$213
Updated
2021/12/16
Apolloscientific
Product number
PC8981
Product name
4-Iodo-2-(trifluoromethyl)pyridine
Purity
95%
Packaging
250mg
Price
$20
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-K-42
Product name
4-Iodo-2-(trifluoromethyl)pyridine
Purity
95%
Packaging
250mg
Price
$32
Updated
2021/12/16
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4-Iodo-2-(trifluoromethyl)pyridine Chemical Properties,Usage,Production

Uses

4-Iodo-2-(trifluoromethyl)pyridine is used as a reagent in the synthesis of aminoisoindoles as β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors which exhibit in vivo brain reduction of β-amyloid peptides.

Reactivity Profile

4-Iodo-2-(trifluoromethyl)pyridine could be cleanly deprotonated by LIDA in tetrahydrofuran at –75 °C[1]. Trapping of the organometallic intermediates with dry ice followed by neutralization gave the 4-iodo-2-(trifluoromethyl)pyridine-3-carboxylic acid (16, 31%). a: LIDA in THF at –75 °C for 2 h; b: (1.) Excess solid carbon dioxide, (2.) Hydrochloric acid.

References

[1] Schlosser M, et al. Further Metalations and Functionalizations of Chloro-, Bromo- and Iodo(trifluoromethyl)pyridines. Synthesis, 2004; 10: 1619-1624.

4-Iodo-2-(trifluoromethyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Iodo-2-(trifluoromethyl)pyridine Suppliers

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View Lastest Price from 4-Iodo-2-(trifluoromethyl)pyridine manufacturers

Dideu Industries Group Limited
Product
4-Iodo-2-(trifluoromethyl)pyridine 590371-73-6
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-27
Career Henan Chemical Co
Product
4-Iodo-2-(trifluoromethyl)pyridine 590371-73-6
Price
US $6.00/KG
Min. Order
1KG
Purity
95%-98%
Supply Ability
100
Release date
2019-09-04

590371-73-6, 4-Iodo-2-(trifluoromethyl)pyridine Related Search:

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  • 4-IODE-2-(TRIFLUOROMETHYL)PYRIDINE
  • 4-Iodo-2-(trifluoromethyl)pyridine ISO 9001：2015 REACH
  • 4-Iode-2-(trifluoromethyl)pyridine (not restricted/prohibited)(lab chemical)
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