Dimethyl 2-(2-methoxyphenoxy)malonate
- Product Name
- Dimethyl 2-(2-methoxyphenoxy)malonate
- CAS No.
- 150726-89-9
- Chemical Name
- Dimethyl 2-(2-methoxyphenoxy)malonate
- Synonyms
- 2-MethoxyphenoxyMalonate;Dimethyl (o-Methoxyphenoxy)malonate;DIMETHYL (2-METHOXYPHENOXY)MALONATE;Dimethyl-2-(2-methoxyphenoxy)malonate;1,3-diMethyl 2-(2-Methoxyphenoxy)propanedioate;2-(2-Methoxyphenoxy)malonic acid dimethyl ester;(2-Methoxyphenoxy)-propanedioic Acid Dimethyl Ester;2-methoxy-2-phenoxypropanedioic acid dimethyl ester;Propanedioic acid, 2-(2-methoxyphenoxy)-, 1,3-dimethyl ester;TIANFUCHEM--150726-89-9--High purity Dimethyl 2-(2-methoxyphenoxy)malonate in stock
- CBNumber
- CB4738859
- Molecular Formula
- C12H14O6
- Formula Weight
- 254.24
- MOL File
- 150726-89-9.mol
Dimethyl 2-(2-methoxyphenoxy)malonate Property
- Boiling point:
- 320.5±27.0 °C(Predicted)
- Density
- 1.206±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Dichloromethane, Methanol
- form
- Solid
- pka
- 12.17±0.59(Predicted)
- color
- White
- InChI
- InChI=1S/C12H14O6/c1-15-8-6-4-5-7-9(8)18-10(11(13)16-2)12(14)17-3/h4-7,10H,1-3H3
- InChIKey
- SBUXKADXTZOBJV-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C(OC1=CC=CC=C1OC)C(OC)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D474785
- Product name
- Dimethyl2-Methoxyphenoxymalonate
- Packaging
- 5g
- Price
- $1175
- Updated
- 2021/12/16
- Product number
- FD22240
- Product name
- Dimethyl 2-methoxyphenoxymalonate
- Packaging
- 10Kg
- Price
- $1365
- Updated
- 2021/12/16
- Product number
- CHM0014259
- Product name
- DIMETHYL 2-METHOXYPHENOXYMALONATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $2044.35
- Updated
- 2021/12/16
- Product number
- FD22240
- Product name
- Dimethyl 2-methoxyphenoxymalonate
- Packaging
- 2Kg
- Price
- $428
- Updated
- 2021/12/16
- Product number
- 074660
- Product name
- Dimethyl 2-(2-methoxyphenoxy)malonate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $572
- Updated
- 2021/12/16
Dimethyl 2-(2-methoxyphenoxy)malonate Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
Dimethyl 2-Methoxyphenoxymalonate (cas# 150726-89-9) is a compound useful in organic synthesis.
Synthesis
28868-76-0
90-05-1
150726-89-9
Sodium methanol solution (2.3 g Na, 0.10 mol, 1.0 eq., dissolved in 75 ml of methanol) was slowly added dropwise to a stirred mixture of guaiacol (12.5 g, 0.100 mol, 1.0 eq.) and dimethyl 2-chloromalonate (19.0 g, 0.114 mol, 1.14 eq.). The reaction mixture was stirred at 45 °C for 1 hour. After completion of the reaction, the volatiles were evaporated by rotary evaporator. The residue was dissolved in toluene and washed sequentially with deionized water and 1% aqueous sodium bicarbonate. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 20.0 g (78.7% yield) of dimethyl 2-(2-methoxyphenoxy)malonate as a viscous oil. The product characterization data were as follows: boiling point 131 °C (literature value 128 °C); 1H NMR (CDCl3) δ 7.12-7.00 (m, 2H), 6.98-6.90 (m, 1H), 6.90-6.82 (m, 1H), 5.27 (s, 1H), 3.85 (s, 3H), 3.84 (s, 6H); 13C NMR ( CDCl3) δ 166.2 (2C), 150.4,146.0,124.4,120.8,119.0,112.5,78.4,55.8,53.0 (2C); HRMS calculated value of C12H14O6 255.0869 (M+H+), measured value 255.0870 (M+H+).
References
[1] European Journal of Medicinal Chemistry, 2016, vol. 121, p. 658 - 670
[2] Organic Preparations and Procedures International, 2016, vol. 48, # 6, p. 481 - 491
[3] Bioorganic and Medicinal Chemistry, 2001, vol. 9, # 4, p. 897 - 907
[4] Patent: US5292740, 1994, A
[5] Patent: WO2011/24056, 2011, A2. Location in patent: Page/Page column 19
Dimethyl 2-(2-methoxyphenoxy)malonate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Dimethyl 2-(2-methoxyphenoxy)malonate manufacturers
- Product
- Dimethyl 2-(2-methoxyphenoxy)malonate 150726-89-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2022-09-30
- Product
- Dimethyl 2-(2-methoxyphenoxy)malonate 150726-89-9
- Price
- US $150.00-100.00/kg
- Min. Order
- 1kg
- Purity
- 604-747-9
- Supply Ability
- 20MT/Month
- Release date
- 2023-11-16
- Product
- Dimethyl 2-(2-methoxyphenoxy)malonate 150726-89-9
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-22