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2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name
2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.
174346-82-8
Chemical Name
2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms
tert-Butyl 2-(hydroxyMethyl)azetidine-1-carboxylate;1-Boc-2-azetidinemethanol;N-Boc-2-azetidinemethanol;1-BOC-2-HYDROXYMETHYL-AZETIDINE;1-Boc-2-azetidinemethanol - [B8003];1-(tert-Butoxycarbonyl)-2-azetidinemethanol;[1-(TERT-BUTOXYCARBONYL)AZETIDIN-2-YL]METHANOL;R,S-1-[(1,1-Dimethylethoxy)carbonyl]azetidine-2-methanol;2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Azetidinecarboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester
CBNumber
CB4763691
Molecular Formula
C9H17NO3
Formula Weight
187.24
MOL File
174346-82-8.mol
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2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property

Boiling point:
270.3±13.0 °C(Predicted)
Density 
1.115±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
14.77±0.10(Predicted)
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
B809838
Product name
[1-(tert-Butoxycarbonyl)azetidin-2-yl]methanol
Packaging
1g
Price
$160
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-MC
Product name
1-Boc-2-azetidinemethanol
Packaging
250mg
Price
$50
Updated
2021/12/16
Synthonix
Product number
B8003
Product name
1-Boc-2-azetidinemethanol
Purity
97.0%
Packaging
1g
Price
$70
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-MC
Product name
1-Boc-2-azetidinemethanol
Packaging
1g
Price
$150
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM1051910
Product name
TERT-BUTYL-2-(HYDROXYMETHYL)AZETIDINE-1-CARBOXYLATE
Purity
95.00%
Packaging
5MG
Price
$457.16
Updated
2021/12/16
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2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Uses

[1-(tert-Butoxycarbonyl)azetidin-2-yl]methanol is used as a potential positiron emission tomography imaging agents for nicotinic acetylcholine receptors.

Synthesis

159749-28-7

174346-82-8

General procedure for the synthesis of tert-butyl 2-hydroxymethyl-azetidine-1-carboxylate from N-Boc-azetidine-2-carboxylic acid: to a solution of N-Boc-azetidine-2-carboxylic acid (1.45 g, 7.21 mmol) in anhydrous THF (12 mL) was added slowly and dropwise borane-methyl sulfide complex (10 M, 3 mL) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred for 3 hours. Upon completion of the reaction, the reaction was quenched with methanol (10 mL) followed by dilution of the reaction mixture with dichloromethane (100 mL). The organic phase was washed with water (40 mL x 3), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford tert-butyl 2-hydroxymethyl-azetidine-1-carboxylate (1.25 g) as a colorless oil.MS-ESI (m/z): 132.0 [M+1-56]+.

References

[1] Patent: WO2015/7219, 2015, A1. Location in patent: Page/Page column 38

2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

China 68 Germany 1 India 1 United States 11 Global 81
NovoChemy Ltd.
Tel
021-31261262/ 49 (0)17662837245
Fax
(0)21-33250524
Email
sales@novochemy.com
Country
Germany
ProdList
6328
Advantage
58
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View Lastest Price from 2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Career Henan Chemical Co
Product
2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 174346-82-8
Price
US $0.01/KG
Min. Order
1KG
Purity
98%; 99%
Supply Ability
500g;1kg； 25kg
Release date
2020-01-09

174346-82-8, 2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

Azetidine (S)-N-BOC-AZETIDINE-2-CARBOXYLIC ACID METHYL ESTER 1-Boc-L-azetidine-2-carboxylic acid AZETIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-ETHYL ESTER (3-[2(S)-N-(TERT-BUTOXYCARBONYL)-2-AZETIDINYL-METHOXY]PYRIDIN-2-YL)TRIMETHYLAMMONIUM TRIFLUOROMETHANESULFONATE Boc-D-Azetidine-2-carboxylic acid (R)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL 2-[[(2-FLUORO-3-PYRIDINYL)OXY]METHYL]-1-AZETIDINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER 2-IODO-3-(1-TERT-BUTOXYCARBONYL-2-(S)-AZETIDINYLMETHOXY)PYRIDINE Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester 1-Boc-azetidine-2-carboxylic acid methyl ester (S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL 1-AZETIDINECARBOXYLIC ACID, 2-[[[2-NITRO-3-PYRIDINYL]OXY]METHYL]-, 1,1-DIMETHYLETHYL ESTER, (2S)- (2S)-2-[[[5-(TRIMETHYLSTANNYL)-3-PYRIDINYL]OXY]METHYL]-1-AZETIDINECARBOXYLIC ACID, T-BUTYL ESTER 2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER H-SAR-OTBU HCL 1-N-Boc-2-(hydroxymethyl)piperazine

  • 2-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • [1-(TERT-BUTOXYCARBONYL)AZETIDIN-2-YL]METHANOL
  • 1-BOC-2-HYDROXYMETHYL-AZETIDINE
  • 1-Boc-2-azetidinemethanol
  • tert-Butyl 2-(hydroxyMethyl)azetidine-1-carboxylate
  • N-Boc-2-azetidinemethanol
  • R,S-1-[(1,1-Dimethylethoxy)carbonyl]azetidine-2-methanol
  • 1-Azetidinecarboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester
  • 1-(tert-Butoxycarbonyl)-2-azetidinemethanol
  • 1-Boc-2-azetidinemethanol - [B8003]
  • 174346-82-8